Global Phylogeography and Genetic Diversity of the Zoonotic Tapeworm Echinococcus Granulosus Sensu Stricto Genotype G1

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Global Phylogeography and Genetic Diversity of the Zoonotic Tapeworm Echinococcus Granulosus Sensu Stricto Genotype G1 Publisher Pubmed

Kinkar L¹ ; Laurimae T¹ ; Acostajamett G² ; Andresiuk V³ ; Balkaya I⁴ ; Casulli A⁵ ; Gasser RB⁶ ; Van Der Giessen J⁷ ; Gonzalez LM⁸ ; Haag KL⁹ ; Zait H¹⁰ ; Irshadullah M¹¹ ; Jabbar A⁶ ; Jenkins DJ¹² Show All Authors

Kinkar L¹
Laurimae T¹
Acostajamett G²
Andresiuk V³
Balkaya I⁴
Casulli A⁵
Gasser RB⁶
Van Der Giessen J⁷
Gonzalez LM⁸
Haag KL⁹
Zait H¹⁰
Irshadullah M¹¹
Jabbar A⁶
Jenkins DJ¹²
Kia EB¹³
Manfredi MT¹⁴
Mirhendi H¹⁵
Mrad S¹⁶
Rostaminejad M¹⁷
Oudnimrad M¹⁶
Pierangeli NB¹⁸
Poncegordo F¹⁹
Rehbein S²⁰
Sharbatkhori M²¹
Simsek S²²
Soriano SV¹⁸
Sprong H⁷
Snabel V²³
Umhang G²⁴
Varcasia A²⁵
Saarma U¹

Source: International Journal for Parasitology Published:2018

Abstract

Echinococcus granulosus sensu stricto (s.s.) is the major cause of human cystic echinococcosis worldwide and is listed among the most severe parasitic diseases of humans. To date, numerous studies have investigated the genetic diversity and population structure of E. granulosus s.s. in various geographic regions. However, there has been no global study. Recently, using mitochondrial DNA, it was shown that E. granulosus s.s. G1 and G3 are distinct genotypes, but a larger dataset is required to confirm the distinction of these genotypes. The objectives of this study were to: (i) investigate the distinction of genotypes G1 and G3 using a large global dataset; and (ii) analyse the genetic diversity and phylogeography of genotype G1 on a global scale using near-complete mitogenome sequences. For this study, 222 globally distributed E. granulosus s.s. samples were used, of which 212 belonged to genotype G1 and 10 to G3. Using a total sequence length of 11,682 bp, we inferred phylogenetic networks for three datasets: E. granulosus s.s. (n = 222), G1 (n = 212) and human G1 samples (n = 41). In addition, the Bayesian phylogenetic and phylogeographic analyses were performed. The latter yielded several strongly supported diffusion routes of genotype G1 originating from Turkey, Tunisia and Argentina. We conclude that: (i) using a considerably larger dataset than employed previously, E. granulosus s.s. G1 and G3 are indeed distinct mitochondrial genotypes; (ii) the genetic diversity of E. granulosus s.s. G1 is high globally, with lower values in South America; and (iii) the complex phylogeographic patterns emerging from the phylogenetic and geographic analyses suggest that the current distribution of genotype G1 has been shaped by intensive animal trade. © 2018 Australian Society for Parasitology

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Style	Citing Format
MLA	Kinkar L, et al.. "Global Phylogeography and Genetic Diversity of the Zoonotic Tapeworm Echinococcus Granulosus Sensu Stricto Genotype G1." International Journal for Parasitology, vol. 48, no. 9-10, 2018, pp. 729-742.
APA	Kinkar L, Laurimae T, Acostajamett G, Andresiuk V, Balkaya I, Casulli A, Gasser RB, Van Der Giessen J, Gonzalez LM, Haag KL, Zait H, Irshadullah M, Jabbar A, Jenkins DJ, Kia EB, Manfredi MT, Mirhendi H, Mrad S, Rostaminejad M, ... Saarma U (2018). Global Phylogeography and Genetic Diversity of the Zoonotic Tapeworm Echinococcus Granulosus Sensu Stricto Genotype G1. International Journal for Parasitology, 48(9-10), 729-742.
Chicago	Kinkar L, Laurimae T, Acostajamett G, Andresiuk V, Balkaya I, Casulli A, Gasser RB, et al.. "Global Phylogeography and Genetic Diversity of the Zoonotic Tapeworm Echinococcus Granulosus Sensu Stricto Genotype G1." International Journal for Parasitology 48, no. 9-10 (2018): 729-742.
Harvard	Kinkar L et al. (2018) 'Global Phylogeography and Genetic Diversity of the Zoonotic Tapeworm Echinococcus Granulosus Sensu Stricto Genotype G1', International Journal for Parasitology, 48(9-10), pp. 729-742.
Vancouver	Kinkar L, Laurimae T, Acostajamett G, Andresiuk V, Balkaya I, Casulli A, et al.. Global Phylogeography and Genetic Diversity of the Zoonotic Tapeworm Echinococcus Granulosus Sensu Stricto Genotype G1. International Journal for Parasitology. 2018;48(9-10):729-742.
BibTex	@article{ author = {Kinkar L and Laurimae T and Acostajamett G and Andresiuk V and Balkaya I and Casulli A and Gasser RB and Van Der Giessen J and Gonzalez LM and Haag KL and Zait H and Irshadullah M and Jabbar A and Jenkins DJ and Kia EB and Manfredi MT and Mirhendi H and Mrad S and Rostaminejad M and Oudnimrad M and Pierangeli NB and Poncegordo F and Rehbein S and Sharbatkhori M and Simsek S and Soriano SV and Sprong H and Snabel V and Umhang G and Varcasia A and Saarma U}, title = {Global Phylogeography and Genetic Diversity of the Zoonotic Tapeworm Echinococcus Granulosus Sensu Stricto Genotype G1}, journal = {International Journal for Parasitology}, volume = {48}, number = {9-10}, pages = {729-742}, year = {2018} }
RIS	TY - JOUR AU - Kinkar L AU - Laurimae T AU - Acostajamett G AU - Andresiuk V AU - Balkaya I AU - Casulli A AU - Gasser RB AU - Van Der Giessen J AU - Gonzalez LM AU - Haag KL AU - Zait H AU - Irshadullah M AU - Jabbar A AU - Jenkins DJ AU - Kia EB AU - Manfredi MT AU - Mirhendi H AU - Mrad S AU - Rostaminejad M AU - Oudnimrad M AU - Pierangeli NB AU - Poncegordo F AU - Rehbein S AU - Sharbatkhori M AU - Simsek S AU - Soriano SV AU - Sprong H AU - Snabel V AU - Umhang G AU - Varcasia A AU - Saarma U TI - Global Phylogeography and Genetic Diversity of the Zoonotic Tapeworm Echinococcus Granulosus Sensu Stricto Genotype G1 JO - International Journal for Parasitology VL - 48 IS - 9-10 SP - 729 EP - 742 PY - 2018 ER -