Isfahan University of Medical Sciences

Science Communicator Platform

Stay connected! Follow us on X network (Twitter):
Share this content! On (X network) By
Evaluation of Insulin Resistance in Obese Women With and Without Acanthosis Nigricans Publisher Pubmed



Sadeghian G1, 2 ; Ziaie H3 ; Amini M4 ; Ali Nilfroushzadeh M2
Authors
Show Affiliations
Authors Affiliations
  1. 1. Skin Disease and Leishmaniasis, Research Center, Sedigheh Tahereh Research and Training Organization, Isfahan, Khoram Street, Jomhoori Square, Iran
  2. 2. Skin Disease and Leishmaniasis Research Center, Isfahan, Iran
  3. 3. Isfahan University of Medical Sciences and Health Services, Isfahan, Iran
  4. 4. Endocrine and Metabolism Research Center, Isfahan, Iran

Source: Journal of Dermatology Published:2009


Abstract

Acanthosis nigricans is characterized by hyperpigmented velvety plaques of body folds and neck. Insulin could be a responsible factor in the pathogenesis of this condition and hyperinsulinemia: a consequence of insulin resistance stimulates the formation of these characteristic plaques. In this study, insulin resistance was compared in obese women with and without acanthosis nigricans. This was a cross-sectional study. Sixty-six obese women (32 patients with acanthosis nigricans and 34 patients without acanthosis nigricans) were selected randomly. Levels of fasting serum insulin and fasting blood glucose were measured in both groups and insulin resistance was determined using homeostasis model assessment. Glucose tolerance test also was performed for all of participants. Five (15.6%) patients with acanthosis nigricans and no (0%) patient without acanthosis nigricans had insulin resistance (P < 0.05). Six (18.7%) patients with acanthosis nigricans and one (2.9%) patient without acanthosis nigricans had impaired glucose tolerance test (P < 0.05). The mean levels of fasting serum insulin were 15.7 ± 8.7 and 12.2 ± 4.1 μm/mL (P < 0.05) and the mean values of insulin resistance index were 3.5 ± 1.9 and 2.6 ± 0.9 μm/mL between patients with and without acanthosis nigricans, respectively (P < 0.05). In Iranian obese women, acanthosis nigricans is a marker of insulin resistance. © 2009 Japanese Dermatological Association.
Related Docs
View other Related Docs
1. Effects of Dietary Approaches to Stop Hypertension Diet Versus Usual Dietary Advice on Glycemic Indices in Women at Risk for Cardiovascular Disease; a Randomized Controlled Clinical Trial, Journal of Renal Injury Prevention (2017)
2. Anthropometric Indices Predicting Incident Type 2 Diabetes in an Iranian Population: The Isfahan Cohort Study, Diabetes and Metabolism (2013)
3. The Prevalence of Impaired Fasting Glucose and Type 2 Diabetes in a Population-Based Sample of Overweight/Obese Children in the Middle East, Pediatric Diabetes (2010)
4. The Product of Triglycerides and Glucose in Comparison With Fasting Plasma Glucose Did Not Improve Diabetes Prediction, Acta Diabetologica (2015)
5. The Visceral Adiposity Index in Comparison With Easily Measurable Anthropometric Markers Did Not Improve Prediction of Diabetes, Canadian Journal of Diabetes (2016)
6. The Characteristics of Pre-Diabetic Patients Associated With Body Composition and Cardiovascular Disease Risk Factors in the Iranian Population, Journal of Research in Medical Sciences (2016)
7. First-Degree Relatives of Patients With Type 2 Diabetes Mellitus and Risk of Non-Alcoholic Fatty Liver Disease, Review of Diabetic Studies (2007)
8. Association of Dietary Pattern and Metabolic Syndrome in 15- to 49-Years-Old Women, Journal of Isfahan Medical School (2015)
Experts (# of related papers)
View all Related Experts
Bijan Iraj (6)
Parvane Saneei (5)
Other Related Docs
9. Progression to Impaired Glucose Metabolism in First-Degree Relatives of Patients With Type 2 Diabetes in Isfahan, Iran, Diabetes/Metabolism Research and Reviews (2009)
10. Neck Circumference in Relation to Glycemic Parameters: A Systematic Review and Meta-Analysis of Observational Studies, Diabetology and Metabolic Syndrome (2019)
11. Association Between High Doses Consumption of Niacin and Type 2 Diabetes, Journal of Babol University of Medical Sciences (2012)
12. Determination of Frequency of Diabetes and Pre-Diabetes in Patients With Nonalcoholic Fatty Liver Disease and Comparison With a Control Group, Journal of Isfahan Medical School (2016)
13. The Effects of Zinc Supplementation on Metabolic Profile and Oxidative Stress in Overweight/Obese Patients With Non-Alcoholic Fatty Liver Disease: A Randomized, Double-Blind, Placebo-Controlled Trial, Journal of Trace Elements in Medicine and Biology (2020)
14. Gaba Dramatically Improves Glucose Tolerance in Streptozotocin-Induced Diabetic Rats Fed With High-Fat Diet, European Journal of Pharmacology (2018)
15. Diet Macronutrients Composition in Nonalcoholic Fatty Liver Disease: A Review on the Related Documents, Hepatitis Monthly (2014)
16. The Association of Hypertriglyceridemic Waist Phenotype With Type 2 Diabetes Mellitus Among Individuals With First Relative History of Diabetes, Journal of Research in Medical Sciences (2011)
17. Clinical Trial of the Effects of Coenzyme Q10 Supplementation on Glycemic Control and Markers of Lipid Profiles in Diabetic Hemodialysis Patients, International Urology and Nephrology (2018)
18. The Relationship Between Low-Carbohydrate Diet Score, Dietary Insulin Index and Load With Obesity in Healthy Adults, Eating and Weight Disorders (2022)
19. Metabolic Syndrome and Nonalcoholic Fatty Liver Disease: Nutritional Approach for Prevention, Journal of Isfahan Medical School (2013)
20. The Effect of Zinc Supplementation on Steatosis Severity and Liver Function Enzymes in Overweight/Obese Patients With Mild to Moderate Non-Alcoholic Fatty Liver Following Calorie-Restricted Diet: A Double-Blind, Randomized Placebo-Controlled Trial, Biological Trace Element Research (2020)
21. Effect of Vanadyl Sulfate on Fructose-Induced Insulin Resistance Rat, Iranian Biomedical Journal (2003)
22. The Impact of a Low Glycemic Index Diet on Inflammatory Markers and Serum Adiponectin Concentration in Adolescent Overweight and Obese Girls: A Randomized Clinical Trial, Hormone and Metabolic Research (2016)
23. The Effect of Okra (Abelmoschus Esculentus) on Lipid Profiles and Glycemic Indices in Type 2 Diabetic Adults: Randomized Double Blinded Trials, Phytotherapy Research (2020)
24. Dietary Patterns, Insulin Resistance, and Prevalence of the Metabolic Syndrome in Women, American Journal of Clinical Nutrition (2007)
25. Association Between Dietary Insulin Index and Load With Brain Derived Neurotrophic Factor, Adropin and Metabolic Health Status in Iranian Adults, Scientific Reports (2023)
26. Dietary Insulin Index and Insulin Load in Relation to Hypertriglyceridemic Waist Phenotype and Low Brain Derived Neurotrophic Factor in Adults, Frontiers in Nutrition (2022)
27. Effects of Paleolithic Diet on Glucose Control in Adults: A Systematic Review and Meta-Analysis of Controlled Clinical Trials, Journal of Nutrition and Food Security (2019)
28. Gamma-Aminobutyric Acid Attenuates Insulin Resistance in Type 2 Diabetic Patients and Reduces the Risk of Insulin Resistance in Their Offspring, Biomedicine and Pharmacotherapy (2021)
29. Effects of Gender and Height on the Oral Glucose Tolerance Test: The Isfahan Diabetes Prevention Study, Review of Diabetic Studies (2008)
30. Association of Major Dietary Patterns With Advanced Glycation End Products and High-Sensitivity C-Reactive Protein in People With Type 1 Diabetes Mellitus, Nutrition Journal (2023)
31. Evaluation of the Effects of Dietary Energy Density on Anthropometric and Glycemic Indices and Lipid Profile in Women With Type 2 Diabetes Mellitus, Journal of Isfahan Medical School (2012)
32. Association Between Dietary Insulin Index and Load With Obesity in Adults, European Journal of Nutrition (2020)
33. The Relationship Between the Nutritioun Status and Insulin Resistance Index in the First Trimester of Pregnancy, Journal of Isfahan Medical School (2020)
34. Modified Alternate-Day Fasting Vs. Calorie Restriction in the Treatment of Patients With Metabolic Syndrome: A Randomized Clinical Trial, Complementary Therapies in Medicine (2019)
35. Gaba Administration Improves Liver Function and Insulin Resistance in Offspring of Type 2 Diabetic Rats, Scientific Reports (2021)
36. Nutrient Patterns in Relation to Insulin Resistance and Endothelial Dysfunction in Iranian Women, Scientific Reports (2024)
37. Comparison of Glycated Hemoglobin With Fasting Plasma Glucose in Definition of Glycemic Component of the Metabolic Syndrome in an Iranian Population, Diabetes and Metabolic Syndrome: Clinical Research and Reviews (2012)
38. Investigation of Cardiovascular Risk Factors in Diabetic and Nondiabetic Patients With Nonalcoholic Fatty Liver Disease, Journal of Research in Medical Sciences (2024)
39. Normalization of Glucose Intolerance in First-Degree Relatives of Patients With Type 2 Diabetes, Diabetes Research and Clinical Practice (2010)
40. Cardiovascular Risk Factors in Relatives of Type 2 Diabetics With Normal Glucose Tolerance Test and Elevated One-Hour Plasma Glucose, Endokrynologia Polska (2010)
41. Comparison of Metabolic Syndrome With Glucose Measurement for Prediction of Type 2 Diabetes: The Isfahan Diabetes Prevention Study, Diabetes and Metabolic Syndrome: Clinical Research and Reviews (2009)
42. People With Impaired Glucose Tolerance and Impaired Fasting Glucose Are Similarly Susceptible to Cardiovascular Disease: A Study in First-Degree Relatives of Type 2 Diabetic Patients, Annals of Nutrition and Metabolism (2010)
43. Prevalence and Risk Factors of Diabetes, Pre-Diabetes and Metabolic Syndrome in First-Degree Relatives of Patients With Type Ii Diabetes, Journal of Kerman University of Medical Sciences (2013)
44. Diabetes and Impaired Glucose Regulation in First-Degree Relatives of Patients With Type 2 Diabetes in Isfahan, Iran: Prevalence and Risk Factors, Review of Diabetic Studies (2007)
45. Should the First Degree Relatives of Type 2 Diabetic Patients With Isolated Impaired Fasting Glucose Be Considered for a Diabetes Primary Prevention Program?, Journal of Research in Medical Sciences (2010)
46. Pre-Diabetes and Cardiovascular Risk Factors in Nafld Patients: A Retrospective Comparative Analysis, Frontiers in Endocrinology (2025)
47. Weight Status of the First-Degree Relatives of Patients With Type 2 Diabetes Based on the Glucose Tolerance Test, Journal of Research in Medical Sciences (2012)
48. Association Between Dietary Glycemic Index and Non-Alcoholic Fatty Liver Disease in Patients With Type 2 Diabetes Mellitus, Frontiers in Endocrinology (2023)
49. Associations of Dietary Glycemic Index and Glycemic Load With Glucose Intolerance in Iranian Adults, International Journal of Diabetes in Developing Countries (2014)
50. The Effect of Fenugreek Seed Supplementation on Serum Irisin Levels, Blood Pressure, and Liver and Kidney Function in Patients With Type 2 Diabetes Mellitus: A Parallel Randomized Clinical Trial, Complementary Therapies in Medicine (2020)