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Metabolic Phenotypes and Risk of Colorectal Cancer: A Systematic Review and Meta-Analysis of Cohort Studies Publisher Pubmed



Goodarzi G1 ; Mozaffari H2 ; Raeisi T3 ; Mehravar F4 ; Razi B5 ; Ghazi ML6 ; Garousi N7 ; Alizadeh S8 ; Janmohammadi P8
Authors
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Authors Affiliations
  1. 1. Department of Nutrition, Science and Research Branch, Islamic Azad University, Tehran, Iran
  2. 2. Faculty of Land and Food Systems, University of British Columbia, Vancouver, Canada
  3. 3. Department of Medicine, Hormozgan University of Medical Sciences, Bandar Abbas, Iran
  4. 4. Department of Epidemiology and Biostatistics, School of Public Health, Tehran University of Medical Sciences (TUMS), Tehran, Iran
  5. 5. Department of Hematology, Faculty of Medical Sciences, Tarbiat Modares University, Tehran, Iran
  6. 6. Department of Exercise Physiology, Central Tehran Branch, Islamic Azad University, Tehran, Iran
  7. 7. Department of Clinical Nutrition, School of Nutrition and Food Science, Isfahan University of Medical Sciences, Isfahan, Iran
  8. 8. Department of Clinical Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences (TUMS), Tehran Province, Tehran, Iran

Source: BMC Cancer Published:2022


Abstract

Background: The association of obesity with colorectal cancer (CRC) may vary depending on metabolic status. Objective: This meta-analysis aimed to investigate the combined impacts of obesity and metabolic status on CRC risk. Methods: The Scopus, PubMed, and web of sciences databases were systematically searched up to Jun 2021 to find all eligible publications examining CRC risk in individuals with metabolically unhealthy normal-weight (MUHNW), metabolically healthy obesity (MHO), and metabolically unhealthy obesity (MUHO) phenotypes. Results: A total of 7 cohort studies with a total of 759,066 participants were included in this meta-analysis. Compared with healthy normal-weight people, MUHNW, MHO, and MUHO individuals indicated an increased risk for CRC with a pooled odds ratio of 1.19 (95% CI = 1.09–1.31) in MUHNW, 1.14 (95% CI = 1.06–1.22) in MHO, and 1.24 (95% CI = 1.19–1.29) in MUHO subjects. When analyses were stratified based on gender, associations remained significant for males. However, the elevated risk of CRC associated with MHO and MUHO was not significant in female participants. Conclusions: The individuals with metabolic abnormality, although at a normal weight, have an increased risk for CRC. Moreover, obesity is associated with CRC irrespective of metabolic status. © 2022, The Author(s).
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