Stem Cells Therapy for Cartilage Regeneration in Clinic: Challenges and Opportunities Publisher



Shahnazari M^{1, 5} ; Malih S^{2, 3} ; Naeimi R^{1, 5} ; Savari M^{1, 5} ; Shokrollah N^{1, 5} ; Samadi P⁴ ; Sheykhhasan M^{1, 5, 6} Show Affiliations
Source: Cartilage: From Biology to Biofabrication Published:2023

Abstract

For both academics and clinicians, the repair and regeneration of articular carti-lage have offered a challenging array of issues. Injuries to articular cartilage have a poor chance of healing since it is an avascular tissue. Small defects may eventually heal on their own without treatment, but the repair tissue is inferior to the body’s own hyaline cartilage because it is made of fibrocartilage. Due to its regenerative capabilities, the idea of stem cell therapy has sparked intense research into its potential application for treating cartilage lesions, including OA. The purpose of this chapter is to present a perspective on stem cell-based therapy for cartilage repair and to highlight recent developments in advanced cell therapy, in particular, the use of embryonic stem cells, mesenchymal stem cells, and induce pluripotent stem cells for treating diseases associated with cartilage defects, particularly OA. © The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer Nature Singapore Pte Ltd. 2023.