Isfahan University of Medical Sciences

Science Communicator Platform

Stay connected! Follow us on X network (Twitter):
Share this content! On (X network) By
Association Between Calcium Intake and Risk of Breast Cancer: An Updated Systematic Review and Dose–Response Meta-Analysis of Cohort Studies Publisher Pubmed



Ghoreishy SM1, 2 ; Bagheri A3 ; Nejad MM3 ; Larijani B4 ; Esmaillzadeh A3, 5, 6
Authors
Show Affiliations
Authors Affiliations
  1. 1. Department of Nutrition, School of Public Health, Iran University of Medical Sciences, Tehran, Iran
  2. 2. Student Research Committee, School of Public Health, Iran University of Medical Sciences, Tehran, Iran
  3. 3. Department of Community Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences, Tehran, Iran
  4. 4. Endocrinology and Metabolism Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran
  5. 5. Obesity and Eating Habits Research Center, Endocrinology and Metabolism Molecular -Cellular Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran
  6. 6. Department of Community Nutrition, School of Nutrition and Food Science, Isfahan University of Medical Sciences, Isfahan, Iran

Source: Clinical Nutrition ESPEN Published:2023


Abstract

Background: Prospective cohort studies that dietary or total calcium intake was considered as the exposure variable and risk of BC as the main or second outcome were included in this systematic review. Methods: We searched the online databases of PubMed, Web of science, Scopus and, Google scholar for relevant studies published up to November 2021, using relevant keywords. Seven cohort studies including 1,579,904 participants, were eligible for the current meta-analysis. Results: Pooled effect size for the highest versus lowest category indicated that increasing dietary calcium intake was significantly associated with a reduced risk of BC (RR, 0.90; 95% CI: 0.81–1.00). However, total calcium intake revealed a non-significant inverse association (RR, 0.97; 95%CI, 0.91–1.03). Dose–response meta-analysis showed that every additional 350 mg per day dietary (RR, 0.94; 95% CI, 0.89–0.99) and total calcium intake (RR, 0.99; 95% CI, 0.97–1.00) was significantly associated with a lower risk of BC. Also, a significant decreasing trend for the risk of BC was observed after 500 mg/d of dietary calcium intake (P-nonlinearity = 0.05, n = 6. Conclusion: Finally, our dose–response meta-analysis revealed a 6 and 1% lower risk of BC in each 350 mg per day increment in dietary and total calcium intake, respectively. © 2023 European Society for Clinical Nutrition and Metabolism
Related Docs
View other Related Docs
1. Coffee Consumption and Caffeine Intake in Relation to Risk of Fractures: A Systematic Review and Dose-Response Meta-Analysis of Observational Studies, Critical Reviews in Food Science and Nutrition (2023)
2. Total, Dietary, and Supplemental Calcium Intake and Mortality From All-Causes, Cardiovascular Disease, and Cancer: A Meta-Analysis of Observational Studies, Nutrition, Metabolism and Cardiovascular Diseases (2015)
3. The Association Between Dietary Calcium Intake and Breast Cancer Risk Among Iranian Women, Nutrition and Cancer (2022)
4. Ultra-Processed Food Consumption and Adult Obesity Risk: A Systematic Review and Dose-Response Meta-Analysis, Critical Reviews in Food Science and Nutrition (2022)
5. Dietary Calcium Intake in Relation to Metabolic Syndrome in Adults: A Systematic Review and Dose–Response Meta-Analysis of Epidemiological Studies With Grade Assessment, Obesity Reviews (2025)
6. Legume Consumption and Risk of All-Cause and Cause-Specific Mortality: A Systematic Review and Dose–Response Meta-Analysis of Prospective Studies, Advances in Nutrition (2023)
7. Dietary Calcium Intake in Relation to Type-2 Diabetes and Hyperglycemia in Adults: A Systematic Review and Dose–Response Meta-Analysis of Epidemiologic Studies, Scientific Reports (2022)
8. Total, Dietary, and Supplemental Calcium Intake and Risk of All-Cause Cardiovascular, and Cancer Mortality: A Systematic Review and Dose-Response Meta-Analysis of Prospective Cohort Studies, Critical Reviews in Food Science and Nutrition (2022)
Experts (# of related papers)
View all Related Experts
Parvane Saneei (28)
Omid Sadeghi (22)
Other Related Docs
9. Egg Consumption and Risk of All-Cause and Cause-Specific Mortality: A Systematic Review and Dose-Response Meta-Analysis of Prospective Studies, Advances in Nutrition (2022)
10. Dietary Intake of Total, Animal and Plant Proteins and the Risk of Coronary Heart Disease and Hypertension: A Systematic Review and Dose-Response Meta-Analysis of Prospective Cohort Studies, Critical Reviews in Food Science and Nutrition (2022)
11. Calcium and Dairy Products in the Chemoprevention of Colorectal Adenomas: A Systematic Review and Meta-Analysis, Critical Reviews in Food Science and Nutrition (2022)
12. Potato Consumption and Risk of All Cause, Cancer and Cardiovascular Mortality: A Systematic Review and Dose-Response Meta-Analysis of Prospective Cohort Studies, Critical Reviews in Food Science and Nutrition (2020)
13. Ultra‐Processed Food Consumption and Adult Mortality Risk: A Systematic Review and Dose–Response Meta‐Analysis of 207,291 Participants, Nutrients (2022)
14. Dose–Response Association Between Animal Protein Sources and Risk of Gestational Diabetes Mellitus: A Systematic Review and Meta-Analysis, Nutrition Reviews (2024)
15. Fruit and Vegetable Intake in Relation to Gastric Cancer Risk: A Comprehensive and Updated Systematic Review and Dose-Response Meta-Analysis of Cohort Studies, Frontiers in Nutrition (2023)
16. Ultra-Processed Food Consumption and Adult Diabetes Risk: A Systematic Review and Dose-Response Meta-Analysis, Nutrients (2021)
17. Relationship Between Maternal Caffeine and Coffee Intake and Pregnancy Loss: A Grading of Recommendations Assessment, Development, and Evaluation-Assessed, Dose-Response Meta-Analysis of Observational Studies, Frontiers in Nutrition (2022)
18. Dietary Carbohydrate Intake and Risk of Bone Fracture: A Systematic Review and Meta-Analysis of Observational Studies, Public Health (2020)
19. A Case-Control Study on Dietary Calcium Intake and Risk of Glioma, European Journal of Cancer Prevention (2021)
20. Caffeine, Type of Coffee, and Risk of Ovarian Cancer: A Dose-Response Meta-Analysis of Prospective Studies, Journal of Clinical Endocrinology and Metabolism (2019)
21. The Effect of Fermented Dairy Intake and Abdominal Obesity in Adults: A Systematic Review and Dose–Response Meta-Analysis of Cohort Studies, Eating and Weight Disorders (2025)
22. Sleep Duration and Sarcopenia Risk: A Systematic Review and Dose-Response Meta-Analysis, Sleep and Breathing (2020)
23. Dietary Calcium Intake in Relation to Blood Lipids and Lipoproteins Profiles: A Systematic Review and Meta-Analysis of Epidemiologic Studies, Nutrition, Metabolism and Cardiovascular Diseases (2022)
24. Total, Dietary, and Supplemental Magnesium Intakes and Risk of All-Cause, Cardiovascular, and Cancer Mortality: A Systematic Review and Dose-Response Meta-Analysis of Prospective Cohort Studies, Advances in Nutrition (2021)
25. The Association of Ultra-Processed Food Consumption With Adult Mental Health Disorders: A Systematic Review and Dose-Response Meta-Analysis of 260,385 Participants, Nutritional Neuroscience (2023)
26. The Association of Ultra-Processed Food Consumption With Adult Inflammatory Bowel Disease Risk: A Systematic Review and Dose-Response Meta-Analysis of 4 035 694 Participants, Nutrition Reviews (2024)
27. Adherence to the Healthy Eating Index and Alternative Healthy Eating Index Dietary Patterns and Mortality From All Causes, Cardiovascular Disease and Cancer: A Meta-Analysis of Observational Studies, Journal of Human Nutrition and Dietetics (2017)
28. Maternal Caffeine Consumption During Pregnancy and Risk of Low Birth Weight: A Dose–Response Meta-Analysis of Cohort Studies, Critical Reviews in Food Science and Nutrition (2022)
29. Serum Vitamin D Levels in Relation to Hypertension and Pre-Hypertension in Adults: A Systematic Review and Dose–Response Meta-Analysis of Epidemiologic Studies, Frontiers in Nutrition (2022)
30. Serum Vitamin D Levels in Relation to Abdominal Obesity: A Systematic Review and Dose–Response Meta-Analysis of Epidemiologic Studies, Obesity Reviews (2021)
31. Coffee Consumption and Risk of Hypertension in Adults: Systematic Review and Meta-Analysis, Nutrients (2023)
32. Effects of a Paleolithic Diet on Cardiovascular Disease Risk Factors: A Systematic Review and Meta-Analysis of Randomized Controlled Trials, Advances in Nutrition (2019)
33. Consumption of Whole Grains and Risk of Type 2 Diabetes: A Comprehensive Systematic Review and Dose–Response Meta-Analysis of Prospective Cohort Studies, Food Science and Nutrition (2022)
34. Exposure to Heavy Metals and the Risk of Osteopenia or Osteoporosis: A Systematic Review and Meta-Analysis, Osteoporosis International (2020)
35. Circulating Vitamin D and the Risk of Gestational Diabetes: A Systematic Review and Dose-Response Meta-Analysis, Endocrine (2020)
36. The Association Between Ultra-Processed Food and Common Pregnancy Adverse Outcomes: A Dose-Response Systematic Review and Meta-Analysis, BMC Pregnancy and Childbirth (2024)
37. The Relationship Between Serum Vitamin D Levels and Risk of Abdominal Obesity: A Systematic Review and Dose-Response Meta-Analysis of Epidemiologic Studies, Iranian Journal of Diabetes and Metabolism (2021)
38. The Association of Ultra-Processed Food Intake With Neurodegenerative Disorders: A Systematic Review and Dose-Response Meta-Analysis of Large-Scale Cohorts, Nutritional Neuroscience (2025)
39. Potato Consumption and Risk of Site-Specific Cancers in Adults: A Systematic Review and Dose-Response Meta-Analysis of Observational Studies, Advances in Nutrition (2021)
40. Association of Dietary Inflammatory Potential With Cardiometabolic Risk Factors and Diseases: A Systematic Review and Dose–Response Meta-Analysis of Observational Studies, Diabetology and Metabolic Syndrome (2020)
41. Dietary Poultry Intake and the Risk of Stroke: A Dose–Response Meta-Analysis of Prospective Cohort Studies, Clinical Nutrition ESPEN (2018)
42. Egg and Dietary Cholesterol Intake and Risk of All-Cause, Cardiovascular, and Cancer Mortality: A Systematic Review and Dose-Response Meta-Analysis of Prospective Cohort Studies, Frontiers in Nutrition (2022)
43. Dietary Intake of Linoleic Acid, Its Concentrations, and the Risk of Type 2 Diabetes: A Systematireview and Dose-Response Meta-Analysis of Prospective Cohort Studies, Diabetes Care (2021)
44. Effects of Cardamom Supplementation on Lipid Profile: A Systematic Review and Meta-Analysis of Randomized Controlled Clinical Trials, Phytotherapy Research (2020)
45. The Effect of Vitamin D Supplementation on Serum Levels of Fibroblast Growth Factor- 23: A Systematic Review and Meta-Analysis of Randomized Controlled Trials, Journal of Steroid Biochemistry and Molecular Biology (2022)
46. Association Between Serum Potassium and Risk of All-Cause Mortality Among Chronic Kidney Diseases Patients: A Systematic Review and Dose–Response Meta-Analysis of More Than One Million Participants, Food Science and Nutrition (2021)
47. Associations Between Exposure to Heavy Metals and the Risk of Chronic Kidney Disease: A Systematic Review and Meta-Analysis, Critical Reviews in Toxicology (2021)
48. The Effects of Green Tea Supplementation on Cardiovascular Risk Factors: A Systematic Review and Meta-Analysis, Frontiers in Nutrition (2023)
49. The Association Between Neighborhood Socioeconomic Status and the Risk of Incidence and Mortality of Colorectal Cancer: A Systematic Review and Meta-Analysis of 1,678,582 Participants, Cancer Epidemiology (2024)
50. Adherence to Dietary Approaches to Stop Hypertension (Dash)-Style Diet and the Risk of Cancer: A Systematic Review and Meta-Analysis of Cohort Studies, Journal of the American College of Nutrition (2019)