Isfahan University of Medical Sciences

Science Communicator Platform

Stay connected! Follow us on X network (Twitter):
Share this content! On (X network) By
Stem Cell-Derived Exosomes As Treatment for Stroke: A Systematic Review Publisher Pubmed



Dehghani L1 ; Hashemi SM1, 2 ; Saadatnia M3 ; Zali A4 ; Oraeeyazdani S4 ; Heidari Keshel S1 ; Khojasteh A1 ; Soleimani M1, 5, 6
Authors
Show Affiliations
Authors Affiliations
  1. 1. Department of Tissue Engineering and Applied Cell Sciences, School of Advanced Technologies in Medicine, Student Research Committee, Shahid Beheshti University of Medical Sciences, Tehran, Iran
  2. 2. Department of Immunology, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran
  3. 3. Department of Neurology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran
  4. 4. Functional Neurosurgery Research Center, Shohada Tajrish Comprehensive Neurosurgical Center of Excellence, Shahid Beheshti University of Medical Sciences, Tehran, Iran
  5. 5. Department of Hematology, Faculty of Medical Sciences, Tarbiat Modares University, Tehran, Iran
  6. 6. Medical Nanotechnology and Tissue engineering Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran

Source: Stem Cell Reviews and Reports Published:2021


Abstract

Background: The therapeutic potential of stem cells may largely be mediated by paracrine factors contained in exosomes released from intracellular endosomes. A systematic review was performed to identify the effects of stem cell-derived exosomes for their ability to induce restorative effects in animal models of stroke. Methods: PubMed, Scopus, and ISI Web of Science databases were searched for all available articles testing stem cell-derived exosomes as therapeutic interventions in animal models of stroke until April 2020. The STAIR scale was used to assess the quality of the included studies. Results: A total of 994 published articles were identified in the systematic search. After screening for eligibility, a total of 16 datasets were included. Type of cerebral ischemia was transient in majority studies and most studies used rat or mice adipose tissue-derived stem cells/bone marrow-derived stem cells. Eight studies indicated improved functional recovery while 8 were able to show reduced infarct volume as a result of exosome therapy. The beneficial effects were mainly attributed to reduced inflammation and oxidative stress, enhanced neurogenesis, angiogenesis, and neurite remodeling. Also, 4 studies demonstrated that exosomes hold great promise as an endogenous drug delivery nano-system. Conclusion: In preclinical studies, use of stem cell-derived exosomes is strongly associated with improved neurological recovery and reduced brain infarct volume following stroke. Improved preclinical study quality in terms of treatment allocation reporting, randomization and blinding will accelerate needed progress towards clinical trials that should assess feasibility and safety of this therapeutic approach in humans. Graphical abstract[Figure not available: see fulltext.] © 2020, Springer Science+Business Media, LLC, part of Springer Nature.
Related Docs
View other Related Docs
1. Safety of Intraparenchymal Injection of Allogenic Placenta Mesenchymal Stem Cells Derived Exosome in Patients Undergoing Decompressive Craniectomy Following Malignant Middle Cerebral Artery Infarct, a Pilot Randomized Clinical Trial, International Journal of Preventive Medicine (2022)
2. Covid-19-Induced Stroke and the Potential of Using Mesenchymal Stem Cells-Derived Extracellular Vesicles in the Regulation of Neuroinflammation, Cellular and Molecular Neurobiology (2023)
3. The Role of Mirnas From Mesenchymal Stem/Stromal Cells-Derived Extracellular Vesicles in Neurological Disorders, Human Cell (2023)
4. Human Adipose Derived Stem Cell Exosomes Enhance the Neural Differentiation of Pc12 Cells, Molecular Biology Reports (2021)
5. Exosomes As Therapeutic and Drug Delivery Vehicle for Neurodegenerative Diseases, Journal of Nanobiotechnology (2024)
6. Intraprostatic Injection of Exosomes Isolated From Adipose-Derived Mesenchymal Stem Cells for the Treatment of Chronic Non-Bacterial Prostatitis, Journal of Tissue Engineering and Regenerative Medicine (2021)
7. Mesenchymal Stem Cell-Derived Extracellular Vesicles: A Novel Cell-Free Therapy, Immunological Investigations (2020)
8. Stem Cell Therapy in Stroke: A Review Literature, International Journal of Preventive Medicine (2013)
Experts (# of related papers)
View all Related Experts
Hossein Salehi (5)
Nahid Eskandari (4)
Other Related Docs
9. Human Placental Mesenchymal Stem Cell-Derived Exosomes in Combination With Hyperbaric Oxygen Synergistically Promote Recovery After Spinal Cord Injury in Rats, Neurotoxicity Research (2023)
10. Combination Therapy of Stem Cell-Derived Exosomes and Biomaterials in the Wound Healing, Stem Cell Reviews and Reports (2022)
11. Advances in Nanotechnology Versus Stem Cell Therapy for the Theranostics of Multiple Sclerosis Disease, Applied Nanoscience (Switzerland) (2023)
12. Exploring the Role of Exosomes in Diabetic Neuropathy: From Molecular Mechanisms to Therapeutic Potential, Biomedicine and Pharmacotherapy (2025)
13. A Systematic Review of Extracellular Vesicles As Non-Invasive Biomarkers in Glioma Diagnosis, Prognosis, and Treatment Response Monitoring, Molecular Biology Reports (2021)
14. The Therapeutic Potential of Human Umbilical Cord Mesenchymal Stromal Cells Derived Exosomes for Wound Healing: Harnessing Exosomes As a Cell-Free Therapy, Journal of Stem Cells and Regenerative Medicine (2024)
15. Enhancing the Wound Healing Process Through Local Injection of Exosomes Derived From Blood Serum: An in Vitro and in Vivo Assessment, Regenerative Therapy (2024)
16. Protein Consumptions in Stroke Patients, Journal of Research in Medical Sciences (2013)
17. Microrna: Relevance to Stroke Diagnosis, Prognosis, and Therapy, Journal of Cellular Physiology (2018)
18. Emerging Role of Mesenchymal Stem/Stromal Cells (Mscs) and Mscs-Derived Exosomes in Bone- and Joint-Associated Musculoskeletal Disorders: A New Frontier, European Journal of Medical Research (2023)
19. Combined Treatment of High-Intensity Interval Training With Neural Stem Cell Generation on Contusive Model of Spinal Cord Injury in Rats, Brain and Behavior (2023)
20. Therapeutic Potential of Mesenchymal Stem Cell-Derived Exosomes As a Cell-Free Therapy Approach for the Treatment of Skin, Bone, and Cartilage Defects, Connective Tissue Research (2022)
21. Hypoxia-Preconditioned Wj-Msc Spheroid-Derived Exosomes Delivering Mir-210 for Renal Cell Restoration in Hypoxia-Reoxygenation Injury, Stem Cell Research and Therapy (2024)
22. Optimizing Acute Ischemic Stroke Outcomes: The Role of Tenecteplase Before Mechanical Thrombectomy, Clinical Therapeutics (2024)
23. Stem Cell-Derived Nano-Scale Vesicles Promotes the Proliferation of Retinal Ganglion Cells (Rgcs) by Activation Pi3k/Akt and Erk Pathway, Nanomedicine Research Journal (2022)
24. Role of Mesenchymal Stem Cells Derived Exosomes Therapy in Neuronal Remodeling After Ischemic Stroke, Minerva Medica (2023)
25. Evaluation of Exosomal Mir-155, Let-7G and Let-7I Levels As a Potential Noninvasive Biomarker Among Refractory/Relapsed Patients, Responsive Patients and Patients Receiving R-Chop, Leukemia and Lymphoma (2019)
26. Niosomes of Ascorbic Acid and Α-Tocopherol in the Cerebral Ischemia-Reperfusion Model in Male Rats, BioMed Research International (2014)
27. Therapeutic Effects of Human Adipose Mesenchymal Stem Cells and Their Paracrine Agents on Sodium Iodate Induced Retinal Degeneration in Rats, Life Sciences (2022)
28. Dietary Patterns in Relation to Stroke Among Iranians: A Case-Control Study, Journal of the American College of Nutrition (2015)
29. Host and Pathogen-Directed Therapies Against Microbial Infections Using Exosome- and Antimicrobial Peptide-Derived Stem Cells With a Special Look at Pulmonary Infections and Sepsis, Stem Cell Reviews and Reports (2023)
30. Therapeutic Effects of Extracellular Vesicles From Human Adipose-Derived Mesenchymal Stem Cells on Chronic Experimental Autoimmune Encephalomyelitis, Journal of Cellular Physiology (2020)