Mesenchymal Stem Cell-Derived Extracellular Vesicles: A Novel Cell-Free Therapy

Isfahan University of Medical Sciences

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Mesenchymal Stem Cell-Derived Extracellular Vesicles: A Novel Cell-Free Therapy Publisher Pubmed

Jafarinia M¹ ; Alsahebfosoul F¹ ; Salehi H² ; Eskandari N¹ ; Ganjalikhanihakemi M¹

Show Affiliations

1. Department of Immunology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran
2. Department of Anatomical Sciences, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran

Source: Immunological Investigations Published:2020

Abstract

In recent years, mesenchymal stem/stromal cells (MSCs) have widely been considered as therapeutic tools in basic researches and clinical trials. Accumulating evidence supports the idea that MSCs perform their therapeutic roles in paracrine manner especially through trophic factors and extracellular vesicles (EVs). Compared to cells, EVs have several advantages to be used as therapeutic agents, such as they lack self-replicating capabilities, dangers of ectopic differentiation, and tumor formation, genetic instability, and cellular rejection by the immune system. Since the MSC-derived EVs (MSC-EVs) appear to exert similar therapeutic effects of their parent cells, such as ability to arrive themselves to the site of injury and immunomodulatory properties, MSC-EVs have been widely studied in many animal models, including kidney, liver, cardiovascular, immunological, and neurological diseases. Regarding this, MSC-EVs look to be a novel and interesting approach to be studied in clinical trials of different inflammatory diseases. In this review, we summarize the properties and applications of MSC-EVs in different diseases. © 2020 Taylor & Francis Group, LLC.

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Style	Citing Format
MLA	Jafarinia M, et al.. "Mesenchymal Stem Cell-Derived Extracellular Vesicles: A Novel Cell-Free Therapy." Immunological Investigations, vol. 49, no. 7, 2020, pp. 758-780.
APA	Jafarinia M, Alsahebfosoul F, Salehi H, Eskandari N, Ganjalikhanihakemi M (2020). Mesenchymal Stem Cell-Derived Extracellular Vesicles: A Novel Cell-Free Therapy. Immunological Investigations, 49(7), 758-780.
Chicago	Jafarinia M, Alsahebfosoul F, Salehi H, Eskandari N, Ganjalikhanihakemi M. "Mesenchymal Stem Cell-Derived Extracellular Vesicles: A Novel Cell-Free Therapy." Immunological Investigations 49, no. 7 (2020): 758-780.
Harvard	Jafarinia M et al. (2020) 'Mesenchymal Stem Cell-Derived Extracellular Vesicles: A Novel Cell-Free Therapy', Immunological Investigations, 49(7), pp. 758-780.
Vancouver	Jafarinia M, Alsahebfosoul F, Salehi H, Eskandari N, Ganjalikhanihakemi M. Mesenchymal Stem Cell-Derived Extracellular Vesicles: A Novel Cell-Free Therapy. Immunological Investigations. 2020;49(7):758-780.
BibTex	@article{ author = {Jafarinia M and Alsahebfosoul F and Salehi H and Eskandari N and Ganjalikhanihakemi M}, title = {Mesenchymal Stem Cell-Derived Extracellular Vesicles: A Novel Cell-Free Therapy}, journal = {Immunological Investigations}, volume = {49}, number = {7}, pages = {758-780}, year = {2020} }
RIS	TY - JOUR AU - Jafarinia M AU - Alsahebfosoul F AU - Salehi H AU - Eskandari N AU - Ganjalikhanihakemi M TI - Mesenchymal Stem Cell-Derived Extracellular Vesicles: A Novel Cell-Free Therapy JO - Immunological Investigations VL - 49 IS - 7 SP - 758 EP - 780 PY - 2020 ER -