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Covid-19-Induced Stroke and the Potential of Using Mesenchymal Stem Cells-Derived Extracellular Vesicles in the Regulation of Neuroinflammation Publisher Pubmed



Norouzibarough L1 ; Asgari Khosroshahi A2 ; Gorji A3, 4 ; Zafari F5 ; Shahverdi Shahraki M6 ; Shirian S6, 7
Authors
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Authors Affiliations
  1. 1. Acquired Immunodeficiency Research Center, Isfahan University of Medical Sciences, Isfahan, Iran
  2. 2. Islamic Azad University, Kazerun Branch, Kazerun, Iran
  3. 3. Epilepsy Research Center, Department of Neurosurgery, Westfalische Wilhelms-Universitat Munster, Munster, Germany
  4. 4. Shefa Neuroscience Research Center, Khatam Alanbia Hospital, Tehran, Iran
  5. 5. Cellular and Molecular Research Center, Research Institute for Prevention of Non- Communicable Disease, Qazvin University of Medical Sciences, Qazvin, Iran
  6. 6. Department of Pathology, School of Veterinary Medicine, Shahrekord University, Shahrekord, Iran
  7. 7. Shiraz Molecular Pathology Research Center, Dr. Daneshbod Pathol Lab, Shiraz, Iran

Source: Cellular and Molecular Neurobiology Published:2023


Abstract

Ischemic stroke (IS) is a known neurological complication of COVID-19 infection, which is associated with high mortality and disability. Following IS, secondary neuroinflammation that occurs can play both harmful and beneficial roles and lead to further injury or repair of damaged neuronal tissue, respectively. Since inflammation plays a pivotal role in the pathogenesis of COVID-19-induced stroke, targeting neuroinflammation could be an effective strategy for modulating the immune responses following ischemic events. Numerous investigations have indicated that the application of mesenchymal stem cells-derived extracellular vesicles (MSC-EVs) improves functional recovery following stroke, mainly through reducing neuroinflammation as well as promoting neurogenesis and angiogenesis. Therefore, MSC-EVs can be applied for the regulation of SARS-CoV-2-mediated inflammation and the management of COVID-19- related ischemic events. In this study, we have first described the advantages and disadvantages of neuroinflammation in the pathological evolution after IS and summarized the characteristics of neuroinflammation in COVID-19-related stroke. Then, we have discussed the potential benefit of MSC-EVs in the regulation of inflammatory responses after COVID-19-induced ischemic events. © 2022, The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.
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