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A Comprehensive Review on Potentially Therapeutic Agents Against Covid-19 From Natural Sources Publisher



Shahali A1, 2, 3 ; Azar ZJ2 ; Ardeshir RA4
Authors
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Authors Affiliations
  1. 1. Department of Pharmaceutical Biotechnology, Faculty of Pharmacy, Isfahan University of Medical Sciences, Isfahan, Iran
  2. 2. Pharmaceutical Sciences Branch, Islamic Azad University, Tehran, Iran
  3. 3. Department of Pharmaceutics, College of Pharmacy, University of the Punjab, Lahore, Pakistan
  4. 4. Faculty of Biotechnology, Amol University of Special Modern Technologies, Amol, Iran

Source: Current Traditional Medicine Published:2024


Abstract

Acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has caused the recent pandemic and worldwide outbreak of respiratory disease. Since there are no known specific drugs for fighting this virus and the process for new drug development is lengthy, scientists have been trying to develop drugs against this viral infection. The potent antiviral activity of natural products has been confirmed in several previous studies. Viral and host proteins contributing to COVID-19 infections can be targeted by natural compounds derived from plants, marine organisms, and microorganisms. The most important of these compounds are polyphenols (e.g., anthraquinone polyphenol, hinokinin, curcumin, and epigallocatechin gallate), alkaloids (e.g., isoquinoline, 10-hydroxyusambarensine, anisotine, and adhatodine), and terpenoids (salvinorin A, thymoquinone, bilobalide, ginkgolide A, and celastrol) from plants, sulphated polysaccharides (carrageenans, chondroitin sulfate C, and fucoidan) from marine organisms, and glycocin F and lactococcin G phycocyanin, and lipopeptide from microorganisms. This study reviews these compounds and their mechanism of action for treating COVID-19 infection and guides researchers in developing effective and safe therapeutic agents against this disease from naturally derived compounds. © 2024 Bentham Science Publishers.
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