Experimental and Computational Interaction Studies of Terbium (Iii) and Lanthanide (Iii) Complexes Containing 2,2′-Bipyridine With Bovine Serum Albumin and Their In Vitro Anticancer and Antimicrobial Activities

Experimental and Computational Interaction Studies of Terbium (Iii) and Lanthanide (Iii) Complexes Containing 2,2′-Bipyridine With Bovine Serum Albumin and Their In Vitro Anticancer and Antimicrobial Activities Publisher Pubmed

Arameshboroujeni Z^{1, 2} ; Aramesh N³ ; Jahani S⁴ ; Khorasanimotlagh M⁵ ; Kerman K⁶ ; Noroozifar M⁶

Show Affiliations

1. Department of Clinical Laboratory, AlZahra Hospital, Isfahan University of Medical Sciences, Isfahan, Iran
2. Young Researchers and Elite Club, Najafabad Branch, Islamic Azad University, Najafabad, Iran
3. Department of Chemistry, Faculty of Sciences, Yasouj University, Yasuj, Iran
4. Non-Communicable Diseases Research Center (NCDRC), Bam University of Medical Sciences, Bam, Iran
5. Department of Chemistry, University of Sistan and Baluchestan, Zahedan, Iran
6. Department of Physical and Environmental Sciences, University of Toronto Scarborough, Toronto, ON, Canada

Source: Journal of Biomolecular Structure and Dynamics Published:2020

Abstract

To investigate the chemotherapeutic and pharmacokinetic aspects of two lanthanide complexes (Tb(III) and La(III) containing 2,2′-bipyridine ligand), in vitro binding studies were carried out with BSA by employing multiple biophysical methods and molecular modeling study. There are different techniques containing fluorescence, absorption spectroscopy and competitive experiments to determine the interaction mode between BSA and these complexes. These complexes efficiently quenched the BSA emission through a static procedure. The results showed that the terbium and lanthanum complexes exhibited a high propensity for BSA interaction via van der Waals force. Further, competitive examination and docking study showed that the interaction site of these complexes on BSA is site III. The results of docking calculations were in good agreement with experimental examinations. Also, the energy transfer from BSA to these complexes has happened with high possibility. Moreover, antimicrobial studies of different bacterial and fungi indicated its promising antibacterial activity. In vitro cytotoxicity of the Tb complex and La complex was carried out in MCF-7 and A-549 cell lines, which revealed significantly good activity. Communicated by Ramaswamy H. Sarma. © 2020, © 2020 Informa UK Limited, trading as Taylor & Francis Group.

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Style	Citing Format
MLA	Arameshboroujeni Z, et al.. "Experimental and Computational Interaction Studies of Terbium (Iii) and Lanthanide (Iii) Complexes Containing 2,2′-Bipyridine With Bovine Serum Albumin and Their In Vitro Anticancer and Antimicrobial Activities." Journal of Biomolecular Structure and Dynamics, vol. , no. , 2020, pp. 1-12.
APA	Arameshboroujeni Z, Aramesh N, Jahani S, Khorasanimotlagh M, Kerman K, Noroozifar M (2020). Experimental and Computational Interaction Studies of Terbium (Iii) and Lanthanide (Iii) Complexes Containing 2,2′-Bipyridine With Bovine Serum Albumin and Their In Vitro Anticancer and Antimicrobial Activities. Journal of Biomolecular Structure and Dynamics, (), 1-12.
Chicago	Arameshboroujeni Z, Aramesh N, Jahani S, Khorasanimotlagh M, Kerman K, Noroozifar M. "Experimental and Computational Interaction Studies of Terbium (Iii) and Lanthanide (Iii) Complexes Containing 2,2′-Bipyridine With Bovine Serum Albumin and Their In Vitro Anticancer and Antimicrobial Activities." Journal of Biomolecular Structure and Dynamics , no. (2020): 1-12.
Harvard	Arameshboroujeni Z et al. (2020) 'Experimental and Computational Interaction Studies of Terbium (Iii) and Lanthanide (Iii) Complexes Containing 2,2′-Bipyridine With Bovine Serum Albumin and Their In Vitro Anticancer and Antimicrobial Activities', Journal of Biomolecular Structure and Dynamics, (), pp. 1-12.
Vancouver	Arameshboroujeni Z, Aramesh N, Jahani S, Khorasanimotlagh M, Kerman K, Noroozifar M. Experimental and Computational Interaction Studies of Terbium (Iii) and Lanthanide (Iii) Complexes Containing 2,2′-Bipyridine With Bovine Serum Albumin and Their In Vitro Anticancer and Antimicrobial Activities. Journal of Biomolecular Structure and Dynamics. 2020;():1-12.
BibTex	@article{ author = {Arameshboroujeni Z and Aramesh N and Jahani S and Khorasanimotlagh M and Kerman K and Noroozifar M}, title = {Experimental and Computational Interaction Studies of Terbium (Iii) and Lanthanide (Iii) Complexes Containing 2,2′-Bipyridine With Bovine Serum Albumin and Their In Vitro Anticancer and Antimicrobial Activities}, journal = {Journal of Biomolecular Structure and Dynamics}, volume = {}, number = {}, pages = {1-12}, year = {2020} }
RIS	TY - JOUR AU - Arameshboroujeni Z AU - Aramesh N AU - Jahani S AU - Khorasanimotlagh M AU - Kerman K AU - Noroozifar M TI - Experimental and Computational Interaction Studies of Terbium (Iii) and Lanthanide (Iii) Complexes Containing 2,2′-Bipyridine With Bovine Serum Albumin and Their In Vitro Anticancer and Antimicrobial Activities JO - Journal of Biomolecular Structure and Dynamics VL - IS - SP - 1 EP - 12 PY - 2020 ER -

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