Evaluation of Parent and Nano-Encapsulated Terbium(Iii) Complex Toward Its Photoluminescence Properties, Fs-Dna, Bsa Binding Affinity, and Biological Applications

Evaluation of Parent and Nano-Encapsulated Terbium(Iii) Complex Toward Its Photoluminescence Properties, Fs-Dna, Bsa Binding Affinity, and Biological Applications Publisher Pubmed

Arameshboroujeni Z^{1, 2} ; Jahani S³ ; Khorasanimotlagh M² ; Kerman K⁴ ; Noroozifar M⁴

Show Affiliations

1. Isfahan University of Medical Sciences, Isfahan, Iran
2. Department of Chemistry, University of Sistan and Baluchestan, Zahedan, 98135-674, Iran
3. Nano Bioeletrochemistry Research Center, Bam University of Medical Sciences, Bam, Iran
4. Department of Physical and Environmental Sciences, University of Toronto Scarborough 1265 Military Trail, Toronto, M1C 1A4, Ontario, Canada

Source: Journal of Trace Elements in Medicine and Biology Published:2020

Abstract

Background: There is a crucial need for finding and developing new compounds as the anticancer and antimicrobial agents with better activity, specific target, and less toxic side effects. Objectives: Base on the potential anticancer properties of lanthanide complexes, in the paper, the biological applications of terbium (Tb) complex, containing 2,9-dimethyl- 1,10-phenanthroline (Me2Phen) such as anticancer, antimicrobial, DNA cleavage ability, the interaction with FS-DNA (Fish-Salmon DNA) and BSA (Bovine Serum Albumin) was examined. Methods: The interaction of Tb-complex with BSA and DNA was studied by emission spectroscopy, absorption titration, viscosity measurement, CD spectroscopy, competitive experiments, and docking calculation. Also, the ability of this complex to cleave DNA was reported by gel electrophoresis. Tb-complex was concurrently screened for its antibacterial activities by different methods. Besides, the nanocarriers of Tb-complex (lipid nanoencapsulation (LNEP) and the starch nanoencapsulation (SNEP)), as active anticancer candidates, were prepared. MTT technique was applied to measure the antitumor properties of these compounds on human cancer cell lines. Results: The experimental and docking results suggest significant binding between DNA as well as BSA with terbium-complex. Besides, groove binding plays the main role in the binding of this compound with DNA and BSA. The competitive experiment with hemin demonstrated that the terbium complex was bound at site III of BSA, which was confirmed by the docking study. Also, Tb-complex was concurrently screened for its DNA cleavage, antimicrobial, and anticancer activities. The anticancer properties of LNEP and SNEP are more than the terbium compound. Conclusions: Tb-complex can bond to DNA/BSA with high binding affinity. Base on biological applications of Tb-complex, it can be concluded that this complex and its nanocarriers can suggest as novel anticancer, antimicrobial candidates. © 2020 Elsevier GmbH

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Mehdi Aliomrani (1)

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Style	Citing Format
MLA	Arameshboroujeni Z, et al.. "Evaluation of Parent and Nano-Encapsulated Terbium(Iii) Complex Toward Its Photoluminescence Properties, Fs-Dna, Bsa Binding Affinity, and Biological Applications." Journal of Trace Elements in Medicine and Biology, vol. 61, no. , 2020, pp. -.
APA	Arameshboroujeni Z, Jahani S, Khorasanimotlagh M, Kerman K, Noroozifar M (2020). Evaluation of Parent and Nano-Encapsulated Terbium(Iii) Complex Toward Its Photoluminescence Properties, Fs-Dna, Bsa Binding Affinity, and Biological Applications. Journal of Trace Elements in Medicine and Biology, 61(), -.
Chicago	Arameshboroujeni Z, Jahani S, Khorasanimotlagh M, Kerman K, Noroozifar M. "Evaluation of Parent and Nano-Encapsulated Terbium(Iii) Complex Toward Its Photoluminescence Properties, Fs-Dna, Bsa Binding Affinity, and Biological Applications." Journal of Trace Elements in Medicine and Biology 61, no. (2020): -.
Harvard	Arameshboroujeni Z et al. (2020) 'Evaluation of Parent and Nano-Encapsulated Terbium(Iii) Complex Toward Its Photoluminescence Properties, Fs-Dna, Bsa Binding Affinity, and Biological Applications', Journal of Trace Elements in Medicine and Biology, 61(), pp. -.
Vancouver	Arameshboroujeni Z, Jahani S, Khorasanimotlagh M, Kerman K, Noroozifar M. Evaluation of Parent and Nano-Encapsulated Terbium(Iii) Complex Toward Its Photoluminescence Properties, Fs-Dna, Bsa Binding Affinity, and Biological Applications. Journal of Trace Elements in Medicine and Biology. 2020;61():-.
BibTex	@article{ author = {Arameshboroujeni Z and Jahani S and Khorasanimotlagh M and Kerman K and Noroozifar M}, title = {Evaluation of Parent and Nano-Encapsulated Terbium(Iii) Complex Toward Its Photoluminescence Properties, Fs-Dna, Bsa Binding Affinity, and Biological Applications}, journal = {Journal of Trace Elements in Medicine and Biology}, volume = {61}, number = {}, pages = {-}, year = {2020} }
RIS	TY - JOUR AU - Arameshboroujeni Z AU - Jahani S AU - Khorasanimotlagh M AU - Kerman K AU - Noroozifar M TI - Evaluation of Parent and Nano-Encapsulated Terbium(Iii) Complex Toward Its Photoluminescence Properties, Fs-Dna, Bsa Binding Affinity, and Biological Applications JO - Journal of Trace Elements in Medicine and Biology VL - 61 IS - SP - EP - PY - 2020 ER -

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