Manganese, Chromium and the Oxidation Status in Bladder Cancer Publisher



Mazdak H^{1, 4} ; Mirkheshti N² ; Movahedian A³ ; Yazdekhasti F² ; Shafian M² Show Affiliations
Source: Trace Elements and Electrolytes Published:2009

Abstract

Introduction: It seems that chromium (Cr) and manganese (Mn) by the mechanism of affecting the oxidative status in cells can play an important role in cancer induction. This motivated the authors to study the serum concentration of Mn, Cr, malondialdehyde (MDA) as a biomarker of lipid peroxidation and total antioxidant capacity (TAC) as an antioxidant marker, in patients with bladder cancer compared with healthy participants. Methods and materials: This is a case control study conducted on 52 patients with bladder cancer and 58 healthy volunteers after controlled for age, sex and smoking. After overnight fasting blood samples were collected. The serum concentration of Cr, Mn, MDA and TAC were determined for all participants. Comparisons made using Student's t-test. Results: Serum concentration of MDA (p value < 0.001) and Cr concentration (p value < 0.05) were significantly increased in patients with bladder cancer. There was a significant decrease in serum concentration of Mn (p value < 0.001) and TAC (p value < 0.001) of patients in comparison with healthy participants. Discussion: Regarding the findings of the study, we propose that a diet rich in Mn and low in Cr and also controlling and lowering the ambient standard for Cr in the environment, may have some more protective role in preventing cancers especially bladder cancer. However further studies are needed to confirm this hypothesis. © 2009 Dustri-Verlag Dr. K. Feistle.