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Advances in Aptamer-Based Drug Delivery Vehicles for Cancer Therapy Publisher



Ghasemii K1 ; Darroudi M2 ; Rahimmanesh I3 ; Ghomi M4 ; Hassanpour M5 ; Sharifi E6, 7 ; Yousefiasl S7 ; Ahmadi S8, 9 ; Zarrabi A10 ; Borzacchiello A11 ; Rabiee M12 ; Paivasantos AC13, 14 ; Rabiee N15, 16
Authors
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Authors Affiliations
  1. 1. Department of Organic Chemistry, Faculty of Chemistry, University of Mazandaran, Babolsar, Iran
  2. 2. Department of Medical Biotechnology and Nanotechnology, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
  3. 3. Applied Physiology Research Center, Cardiovascular Research Institute, Isfahan University of Medical Sciences, Isfahan, 8174673461, Iran
  4. 4. School of Chemistry, Damghan University, Damghan, 36716-41167, Iran
  5. 5. Department of Chemistry, Institute for Advanced Studies in Basic Sciences (IASBS), Zanjan, 45137-66731, Iran
  6. 6. Institute for Polymers, Composites and Biomaterials, National Research Council (IPCB-CNR), Naples, 80125, Italy
  7. 7. Department of Tissue Engineering and Biomaterials, School of Advanced Medical Sciences and Technologies, Hamadan University of Medical Sciences, Hamadan, 6517838736, Iran
  8. 8. Department of Medical Biotechnology, School of Advanced Technologies in Medicine, Shahid Beheshti University of Medical Sciences, Tehran, 19857-17443, Iran
  9. 9. Cellular and Molecular Biology Research Center, Shahid Beheshti University of Medical Sciences, Tehran, 19857-17443, Iran
  10. 10. Department of Biomedical Engineering, Faculty of Engineering & Natural Science, Istinye University, Istanbul, Sariyer, 34396, Turkey
  11. 11. Institute for Polymers, Composites and Biomaterials, National Research Council, IPCB-CNR, Naples, 80125, Italy
  12. 12. Biomaterial group, Department of Biomedical Engineering, Amirkabir University of Technology, Tehran, Iran
  13. 13. Department of Pharmaceutical Technology, Faculty of Pharmacy, University of Coimbra, Coimbra, 3000-548, Portugal
  14. 14. REQUIMTE/LAQV, Group of Pharmaceutical Technology, Faculty of Pharmacy, University of Coimbra, Coimbra, 3000-548, Portugal
  15. 15. Department of Materials Science and Engineering, Pohang University of Science and Technology (POSTECH), 77 Cheongam-ro, Nam-gu, Pohang, 37673, Gyeongbuk, South Korea
  16. 16. School of Engineering, Macquarie University, Sydney, 2109, NSW, Australia

Source: Biomaterials Advances Published:2022


Abstract

Overall, aptamers are special classes of nucleic acid-based macromolecules that are beginning to investigate because of their capability of avidity binding to a specific target for clinical use. Taking advantage of target-specific medicine led to more effective therapeutic and limitation of side effects of drugs. Herein, we discuss several aptamers and their binding capability and capacity for selecting tumor biomarkers and usage of them as targeting ligands for the functionalization of nanomaterials. We review recent applications based on aptamers and several nanoparticles to rise efficacy and develop carrier systems such as graphene oxide, folic acid, gold, mesopores silica, and various polymers and copolymer, polyethylene glycol, cyclodextrin, chitosan. The nanocarriers have been characterized by particle size, zeta potential, aptamer conjugation, and drug encapsulation efficiency. Hydrodynamic diameter and Zeta potential can used in order to monitor aptamers' crosslinking, in-vitro drug release, intracellular delivery of nanocarriers, and cellular cytotoxicity assay. Also, they are studied for cellular uptake and internalization to types of cancer cell lines such as colorectal, breast, prostate, leukemia and etc. The results are investigated in in-vivo cytotoxicity assay and cell viability assay. Targeted cancer therapy seems a good and promising strategy to overcome the systemic toxicity of chemotherapy. © 2022
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