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Clinical Breast Cancer Registry of Ir. Iran (Cbcr-Ir): Study Protocol and First Results Publisher Pubmed



Seyyedsalehi MS1, 2 ; Nahvijou A2 ; Javanmard SH3 ; Rajabpour MV2 ; Manteghinejad A4 ; Pirnejad H5, 6 ; Niazkhani Z7 ; Sorkheh AG8 ; Baniamer M9 ; Anasari J10 ; Bahrami M11 ; Marzban M12, 13 ; Esfandiari A14 ; Ghoreishi SM15 Show All Authors
Authors
  1. Seyyedsalehi MS1, 2
  2. Nahvijou A2
  3. Javanmard SH3
  4. Rajabpour MV2
  5. Manteghinejad A4
  6. Pirnejad H5, 6
  7. Niazkhani Z7
  8. Sorkheh AG8
  9. Baniamer M9
  10. Anasari J10
  11. Bahrami M11
  12. Marzban M12, 13
  13. Esfandiari A14
  14. Ghoreishi SM15
  15. Nikbakhsh N16
  16. Nia YBI17
  17. Somaghian SA18
  18. Ashoobi MT19, 20
  19. Bakhshi F21
  20. Ansarimoghaddam A22
  21. Bakhshi M22
  22. Binabaj MM23
  23. Nourmohammadi H24
  24. Omranipour R25
  25. Zendehdel K2, 26
Show Affiliations
Authors Affiliations
  1. 1. Department of Medical and Surgical Sciences, University of Bologna, Italy
  2. 2. Cancer Research Centre, Cancer Institute, Tehran University of Medical Sciences, Tehran, Iran
  3. 3. Applied Physiology Research Center, Isfahan Cardiovascular Research Institute, Isfahan University of Medical Science, Isfahan, Iran
  4. 4. Cancer Prevention Research Center, Omid Hospital, Isfahan University of Medical Sciences, Isfahan, Iran
  5. 5. Patient Safety Research Center, Clinical Research Institute, Urmia University of Medical Sciences, Urmia, Iran
  6. 6. Erasmus School of Health Policy & Management (ESHPM), Erasmus University Rotterdam, Rotterdam, Netherlands
  7. 7. Nephrology and Kidney Transplant Research Center, Clinical Research Institute, Urmia University of Medical Sciences, Urmia, Iran
  8. 8. Department of Surgery, School of Medicine, Kermanshah University of Medical Sciences, Kermanshah, Iran
  9. 9. Department of Chemical Engineering, Amirkabir University of Technology (Tehran Polytechnic), Tehran, Iran
  10. 10. Depertment of Radiation Oncology, Arak University of Medical Sciences, Arak, Iran
  11. 11. Arak University of Medical Sciences, Arak, Iran
  12. 12. Clinical Research Development Center, The Persian Gulf Martyrs, Bushehr University of Medical Science, Bushehr, Iran
  13. 13. Statistical Genetics Lab, QIMR Berghofer Medical Research Institute, Brisbane, QLD, Australia
  14. 14. Department of Health Policy and Management, School of Medicine, Bushehr University of Medical Sciences, Bushehr, Iran
  15. 15. Cellular and Molecular Research Center, Health Research Institute, Babol University of Medical Sciences, Babol, Iran
  16. 16. Cancer Research Center, Health Research Institute, Babol University of Medical Sciences, Babol, Iran
  17. 17. Department of Internal Medicine, Lorestan University of Medical Sciences, Khorramabad, Iran
  18. 18. Shahid Rahimi Hospital, Lorestan University of Medical Sciences, Khorramabad, Iran
  19. 19. Razi Clinical Research Development Unit, Guilan University of Medical Sciences, Rasht, Iran
  20. 20. Guilan Road Trauma Research Center, Guilan University of Medical Sciences, Rasht, Iran
  21. 21. Social Determinants of Health Research Center, School of Health, Guilan University of Medical Sciences, Rasht, Iran
  22. 22. Health Promotion Research Center, Zahedan University of Medical Sciences, Zahedan, Iran
  23. 23. Non-Communicable Diseases Research Center, Sabzevar University of Medical Sciences, Sabzevar, Iran
  24. 24. Department of Internal Medicine, Shahid Mostafa Khomeini Hospital, Ilam, Iran
  25. 25. Department of Surgical Oncology, Cancer Institute, Tehran University of Medical Sciences, Tehran, Iran
  26. 26. Cancer Biology Research Center, Cancer Institute, Tehran University of Medical Sciences, Tehran, Iran

Source: Archives of Iranian Medicine Published:2023


Abstract

Background: Breast cancer (BC), as a significant global health problem, is the most common cancer in women. Despite the importance of clinical cancer registries in improving the quality of cancer care and cancer research, there are few reports on them from low- and middle-income countries. We established a multicenter clinical breast cancer registry in Iran (CBCR-IR) to collect data on BC cases, the pattern of care, and the quality-of-care indicators in different hospitals across the country. Methods: We established a clinical cancer registry in 12 provinces of Iran. We defined the organizational structure, developed minimal data sets and data dictionaries, verified data sources and registration processes, and developed the necessary registry software. During this registry, we studied the clinical characteristics and outcomes of patients with cancer who were admitted from 2014 onwards. Results: We registered 13 086 BC cases (7874 eligible cases) between 1.1.2014 and 1.1.2022. Core needle biopsy from the tumor (61.25%) and diagnostic mammography (68.78%) were the two most commonly used diagnostic methods. Stage distribution was 2.03% carcinoma in situ, 12% stage I, 44.65% stage II, 21.32% stage III, and 4.61% stage IV; stage information was missing in 1532 patients (19.46%). Surgery (95.01%) and chemotherapy (79.65%) were the most common treatments for all patients. Conclusion: The information provided by this registry can be used to evaluate and improve the quality of care for BC patients. It will be scaled up to the national level as an important resource for measuring quality of care and conducting clinical cancer research in Iran. © 2023 Academy of Medical Sciences of I.R. Iran. All rights reserved.
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