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Antimicrobial Peptides Against Arboviruses: Mechanisms, Challenges, and Future Directions Publisher



Owliaee I1, 2 ; Khaledian M1, 3 ; Shojaeian A4 ; Madanchi H5, 6 ; Yarani R7, 8 ; Boroujeni AK9 ; Shoushtari M10
Authors
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Authors Affiliations
  1. 1. Student Research Committee, Hamadan University of Medical Sciences, Hamadan, 65178-38736, Iran
  2. 2. Department of Medical Virology, Faculty of Medicine, Hamadan University of Medical Sciences, Hamadan, 65178-38736, Iran
  3. 3. Department of Medical Entomology, Faculty of Medicine, Hamadan University of Medical Sciences, Hamadan, 65178-38736, Iran
  4. 4. Research Center for Molecular Medicine, Institute of Cancer, Avicenna Health Research Institute, Hamadan University of Medical Sciences, Hamadan, Iran
  5. 5. Department of Medical Biotechnology, Faculty of Medicine, Semnan University of Medical Sciences, Semnan, 35147-99442, Iran
  6. 6. Drug Design and Bioinformatics Unit, Medical Biotechnology Department, Biotechnology Research Center, Pasteur Institute of Iran, Tehran, 13169-43551, Iran
  7. 7. Interventional Radiology Innovation at Stanford (IRIS), Department of Radiology, Stanford University School of Medicine, Stanford, CA, United States
  8. 8. Translational Type 1 Diabetes Research, Department of Clinical Research, Steno Diabetes Center Copenhagen, Herlev, Denmark
  9. 9. Skin Disease and Leishmaniasis Research Center, Isfahan University of Medical Sciences, Isfahan, Iran
  10. 10. Department of Virology, Pasteur Institute of Iran, Tehran, 13169-43551, Iran

Source: Probiotics and Antimicrobial Proteins Published:2025


Abstract

This review delves into the potential of antimicrobial peptides (AMPs) as promising candidates for combating arboviruses, focusing on their mechanisms of antiviral activity, challenges, and future directions. AMPs have shown promise in preventing arbovirus attachment to host cells, inducing interferon production, and targeting multiple viral stages, illustrating their multifaceted impact on arbovirus infections. Structural elucidation of AMP–viral complexes is explored to deepen the understanding of molecular determinants governing viral neutralization, paving the way for structure-guided design. Furthermore, this review highlights the potential of AMP-based combination therapies to create synergistic effects that enhance overall treatment outcomes while minimizing the likelihood of resistance development. Challenges such as susceptibility to proteases, toxicity, and scalable production are discussed alongside strategies to address these limitations. Additionally, the expanding applications of AMPs as vaccine adjuvants and antiviral delivery systems are emphasized, underscoring their versatility beyond direct antiviral functions. © The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature 2024.
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