Immune and Bioinformatics Identification of T Cell and B Cell Epitopes in the Protein Structure of Sars-Cov-2: A Systematic Review Publisher Pubmed



Noorimotlagh Z^{1, 2} ; Karami C³ ; Mirzaee SA^{1, 2} ; Kaffashian M⁴ ; Mami S⁵ ; Azizi M⁶
Source: International Immunopharmacology Published:2020

Abstract

The beginning of 2020 was marked as the emergence of a COVID-19 outbreak caused by a new coronavirus, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Currently, there is no vaccine or approved treatment for this infectious virus so the invention of an efficient vaccine is certainly a high priority. Some studies have employed several techniques to facilitate the combination of the immunoinformatics approach and comparative genomic approach in order to determine the potential peptides for designing the T-cell epitope-based peptide vaccine using the 2019-nCoV envelope protein as a target. Via screening the bioimmunoinformatic SARS-CoV2 derived B-cell and T-cell epitopes within the basic immunogenic of SARS-CoV2 proteins, we presented a set of inferred B-cell and T-cell epitopes from the spike (S) and nucleocapsid (N) proteins with high antigenicity and without allergenic property or toxic effects. Our findings provide a screened set of epitopes that can be introduced as potential targets for developing peptide vaccines against the SARS-CoV-2 virus. © 2020 Elsevier B.V.