The Adjuvant Therapy of Edible Herbal Product Including Colchicum Bulb, Olive Leaf, Black Cumin Seeds, Lavender Flower, and Ginger Rhizome on the Outcome of Patients With Severe and Critical Covid-19: A Double-Blind Randomized Controlled Clinical Trial

Science Communicator Platform

Stay connected! Follow us on X network (Twitter):

Share this content! On (X network) By

The Adjuvant Therapy of Edible Herbal Product Including Colchicum Bulb, Olive Leaf, Black Cumin Seeds, Lavender Flower, and Ginger Rhizome on the Outcome of Patients With Severe and Critical Covid-19: A Double-Blind Randomized Controlled Clinical Trial Publisher

Sebghatollahi V¹ ; Dastjerdi MS² ; Ghiasi F³ ; Alikiaii B⁴ ; Pourahmad M⁵ ; Yegdaneh A⁶ ; Akbari M⁷ ; Ghadiri R⁸

Show Affiliations

1. Department of Gastroenterology and Hepatology, Isfahan University of Medical Sciences, Isfahan, Iran
2. Department of Endocrine and Metabolism, Isfahan Endocrine and Metabolism Research Center, Isfahan University of Medical Sciences, Isfahan, Iran
3. Department of Pulmonary Diseases, Isfahan University of Medical Sciences, Isfahan, Iran
4. Department of Anesthesiology, Anesthesiology and Critical Care Research Center, Isfahan University of Medical Sciences, Isfahan, Iran
5. Department of Infectious Disease and Tropical Medicine, Nosocomial Infection Research Center, Isfahan University of Medical Sciences, Isfahan, Iran
6. Department of Pharmacognosy, School of Pharmacy and Pharmaceutical Sciences, Pharmaceutical Sciences Research Center, Isfahan University of Medical Sciences, Isfahan, Iran
7. Department of Epidemiology, Isfahan Endocrine and Metabolism Research Center, Isfahan University of Medical Sciences, Isfahan, Iran
8. Department of Traditional Medicine, Isfahan University of Medical Sciences, Isfahan, Iran

Source: Avicenna Journal of Phytomedicine Published:2024

Abstract

Objective: The present study aimed at evaluating the effect of combination of medicinal plants, including Colchicum autumnal L., Olea europaea L., Nigella sativa L., Lavandula angustifolia L., and Zingiber officinale Roscoe, on the recovery and outcome of COVID-19 patients. Materials and Methods: This study was conducted on 150 COVID-19 patients. All patients received both pharmaceutical and supportive treatments. In addition to the standard care treatment, intervention group received two capsules of herbal medicine orally every 8 hours, while control group received placebo. Results: Oxygen saturation percentage (SpO2) of the intervention group (median:88.00) was significantly higher than that of the control group (median:86.00), while C-reactive protein (CRP) of the intervention group (median:20.00) was significantly lower than that of the control group (median:28.00) at the time of hospital discharge (p<0.05). Conclusion: The combination of studied medicinal plants could significantly reduce the oxygen requirement and oxygen therapy. © 2024 Mashhad University of Medical Sciences. All rights reserved.

Related Docs

View other Related Docs

1. Antioxidant Plants and Diabetes Mellitus, Journal of Research in Medical Sciences (2015)

2. Application of Some Herbal Medicine Used for the Treatment of Osteoarthritis and Chondrogenesis, Traditional and Integrative Medicine (2020)

3. The Influence of Propolis Plus Hyoscyamus Niger L. Against Covid-19: A Phase Ii, Multicenter, Placebo-Controlled, Randomized Trial, Phytotherapy Research (2024)

4. A Narrative Literature Review on Traditional Medicine Options for Treatment of Corona Virus Disease 2019 (Covid-19), Complementary Therapies in Clinical Practice (2020)

5. The Effects of Herbal Medicines on Cancer Therapy-Induced Oral Mucositis: A Literature Review, Phytotherapy Research (2022)

6. Effect of Curcumin-Pipeine Supplementation on Clinical Status, Mortality Rate, Oxidative Stress, and Inflammatory Markers in Critically Ill Icu Patients With Covid-19: A Structured Summary of a Study Protocol for a Randomized Controlled Trial, Trials (2021)

7. Efficacy and Safety of Add-On Viola Odorata L. in the Treatment of Covid-19: A Randomized Double-Blind Controlled Trial, Journal of Ethnopharmacology (2023)

8. The Effects of Nutraceuticals and Bioactive Natural Compounds on Chronic Periodontitis: A Clinical Review, Advances in Experimental Medicine and Biology (2021)

Experts (# of related papers)

View all Related Experts

Mohammad Bagherniya (4)

Bijan Iraj (2)

Other Related Docs

9. Efficacy of Persian Medicine Herbal Formulations (Capsules And Decoction) Compared to Standard Care in Patients With Covid-19, a Multicenter Open-Labeled, Randomized, Controlled Clinical Trial, Phytotherapy Research (2021)

10. Evaluating Anti-Inflammatory Effect of Hydroalcoholic Extracts of Citrus Medica L. Pulp and Peel on Rat Model of Acute Colitis, Research Journal of Pharmacognosy (2023)

11. Effects of Cinnamon, Cardamom, Saffron, and Ginger Consumption on Markers of Glycemic Control, Lipid Profile, Oxidative Stress, and Inflammation in Type 2 Diabetes Patients, The review of diabetic studies : RDS (2014)

12. Clinical Efficacy of Stragol™ Herbal Heart Drop in Ischemic Heart Failure of Stable Chest Angina, European Journal of Integrative Medicine (2011)

13. The Effect of Vitamin E and Vitamin C in Patients With Covid-19 Pneumonia; a Randomized Controlled Clinical Trial, Immunopathologia Persa (2022)

14. Heart Palpitation Relief With Melissa Officinalis Leaf Extract: Double Blind, Randomized, Placebo Controlled Trial of Efficacy and Safety, Journal of Ethnopharmacology (2015)

15. Effects of Curcumin-Piperine Co-Supplementation on Clinical Signs, Duration, Severity, and Inflammatory Factors in Patients With Covid-19: A Structured Summary of a Study Protocol for a Randomised Controlled Trial, Trials (2020)

16. The Role of Hydroxychloroquine in Covid-19 Treatment: A Systematic Review and Meta-Analysis, Annals of the Academy of Medicine Singapore (2020)

17. The Effect of Nigella Sativa L. Supplementation on Serum C-Reactive Protein: A Systematic Review and Meta‐Analysis of Randomized Controlled Trials, Complementary Therapies in Medicine (2019)

18. From Kitchen to Clinic: Pharmacotherapeutic Potential of Common Spices in Indian Cooking in Age-Related Neurological Disorders, Frontiers in Pharmacology (2022)

19. The Pros and Cons of Using Elderberry (Sambucus Nigra) for Prevention and Treatment of Covid-19, Advanced Biomedical Research (2022)

20. In Vitro and in Vivo Anthelmintic Activity of Seed Extract of Coriandrum Sativum Compared to Niclosamid Against Hymenolepis Nana Infection, Journal of Parasitic Diseases (2016)

21. Herbal Medications to Manage Insomnia: An Overview of Clinical Trials Using Herbal Treatment for Insomnia, Traditional and Integrative Medicine (2022)

Style	Citing Format
MLA	Sebghatollahi V, et al.. "The Adjuvant Therapy of Edible Herbal Product Including Colchicum Bulb, Olive Leaf, Black Cumin Seeds, Lavender Flower, and Ginger Rhizome on the Outcome of Patients With Severe and Critical Covid-19: A Double-Blind Randomized Controlled Clinical Trial." Avicenna Journal of Phytomedicine, vol. 14, no. 6, 2024, pp. 686-698.
APA	Sebghatollahi V, Dastjerdi MS, Ghiasi F, Alikiaii B, Pourahmad M, Yegdaneh A, Akbari M, Ghadiri R (2024). The Adjuvant Therapy of Edible Herbal Product Including Colchicum Bulb, Olive Leaf, Black Cumin Seeds, Lavender Flower, and Ginger Rhizome on the Outcome of Patients With Severe and Critical Covid-19: A Double-Blind Randomized Controlled Clinical Trial. Avicenna Journal of Phytomedicine, 14(6), 686-698.
Chicago	Sebghatollahi V, Dastjerdi MS, Ghiasi F, Alikiaii B, Pourahmad M, Yegdaneh A, Akbari M, Ghadiri R. "The Adjuvant Therapy of Edible Herbal Product Including Colchicum Bulb, Olive Leaf, Black Cumin Seeds, Lavender Flower, and Ginger Rhizome on the Outcome of Patients With Severe and Critical Covid-19: A Double-Blind Randomized Controlled Clinical Trial." Avicenna Journal of Phytomedicine 14, no. 6 (2024): 686-698.
Harvard	Sebghatollahi V et al. (2024) 'The Adjuvant Therapy of Edible Herbal Product Including Colchicum Bulb, Olive Leaf, Black Cumin Seeds, Lavender Flower, and Ginger Rhizome on the Outcome of Patients With Severe and Critical Covid-19: A Double-Blind Randomized Controlled Clinical Trial', Avicenna Journal of Phytomedicine, 14(6), pp. 686-698.
Vancouver	Sebghatollahi V, Dastjerdi MS, Ghiasi F, Alikiaii B, Pourahmad M, Yegdaneh A, et al.. The Adjuvant Therapy of Edible Herbal Product Including Colchicum Bulb, Olive Leaf, Black Cumin Seeds, Lavender Flower, and Ginger Rhizome on the Outcome of Patients With Severe and Critical Covid-19: A Double-Blind Randomized Controlled Clinical Trial. Avicenna Journal of Phytomedicine. 2024;14(6):686-698.
BibTex	@article{ author = {Sebghatollahi V and Dastjerdi MS and Ghiasi F and Alikiaii B and Pourahmad M and Yegdaneh A and Akbari M and Ghadiri R}, title = {The Adjuvant Therapy of Edible Herbal Product Including Colchicum Bulb, Olive Leaf, Black Cumin Seeds, Lavender Flower, and Ginger Rhizome on the Outcome of Patients With Severe and Critical Covid-19: A Double-Blind Randomized Controlled Clinical Trial}, journal = {Avicenna Journal of Phytomedicine}, volume = {14}, number = {6}, pages = {686-698}, year = {2024} }
RIS	TY - JOUR AU - Sebghatollahi V AU - Dastjerdi MS AU - Ghiasi F AU - Alikiaii B AU - Pourahmad M AU - Yegdaneh A AU - Akbari M AU - Ghadiri R TI - The Adjuvant Therapy of Edible Herbal Product Including Colchicum Bulb, Olive Leaf, Black Cumin Seeds, Lavender Flower, and Ginger Rhizome on the Outcome of Patients With Severe and Critical Covid-19: A Double-Blind Randomized Controlled Clinical Trial JO - Avicenna Journal of Phytomedicine VL - 14 IS - 6 SP - 686 EP - 698 PY - 2024 ER -

Science Communicator Platform

Authors

Authors Affiliations

Abstract