Isfahan University of Medical Sciences

Science Communicator Platform

Stay connected! Follow us on X network (Twitter):
Share this content! On (X network) By
The Effects of Herbal Medicines on Cancer Therapy-Induced Oral Mucositis: A Literature Review Publisher Pubmed



Safarzadeh S1 ; Shirban F2 ; Bagherniya M3, 4, 5 ; Sathyapalan T6 ; Sahebkar A7, 8, 9, 10
Authors
Show Affiliations
Authors Affiliations
  1. 1. Post Graduate Student, Dental Students’ Research Committee, Department of Orthodontics, School of Dentistry, Isfahan University of Medical Sciences, Isfahan, Iran
  2. 2. Department of Orthodontics, Dental Research Center, Dental Research Institute, School of Dentistry, Isfahan University of Medical Sciences, Isfahan, Iran
  3. 3. Food Security Research Center, Isfahan University of Medical Sciences, Isfahan, Iran
  4. 4. Anesthesia and Critical Care Research Center, Isfahan University of Medical Sciences, Isfahan, Iran
  5. 5. Department of Community Nutrition, School of Nutrition and Food Science, Isfahan University of Medical Sciences, Isfahan, Iran
  6. 6. Department of Academic Diabetes, Endocrinology and Metabolism, Hull York Medical School, University of Hull, Hull, United Kingdom
  7. 7. Biotechnology Research Center, Pharmaceutical Technology Institute, Mashhad University of Medical Sciences, Mashhad, Iran
  8. 8. Applied Biomedical Research Center, Mashhad University of Medical Sciences, Mashhad, Iran
  9. 9. School of Medicine, The University of Western Australia, Perth, WA, Australia
  10. 10. School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran

Source: Phytotherapy Research Published:2022


Abstract

Cancer therapy-induced oral mucositis (OM) is one of the most troublesome morbidities after radio-chemotherapy. Age, nutritional status, tumor type, oral hygiene, and treatment method are the determinants for OM incidence. In addition, oxygen-free radicals can act as a trigger for an inflammatory milieu that causes OM. Based on the debilitating nature of OM, finding a safe and inexpensive agent with anti-inflammatory, anti-microbial, and antioxidative properties can be valuable for this situation. Considering the harmful effects of some chemical agents, herbal medicine has been suggested as a potential alternative owing to unique properties such as safety, availability and low cost. Many studies have illustrated several pharmacological properties of herbal medicines in recent years, such as anti-inflammatory, anti-microbial, and antioxidative activities, which are essential factors in the palliation of cancer therapy-induced OM. This review aimed to evaluate herbal medicines' effects on cancer therapy-induced OM. According to this comprehensive review, it is concluded that medicinal plants and phytochemicals can be used as practical agents in the palliation of cancer therapy-induced OM without any serious side effects. © 2021 John Wiley & Sons Ltd.
Related Docs
View other Related Docs
1. Investigating the Effect of Aloe Vera on the Prevention and Treatment of Radiotherapy‑Induced Oral Mucositis in Patients With Head‑And‑Neck Cancer, Journal of Research in Medical Sciences (2024)
2. The Effects of Nutraceuticals and Bioactive Natural Compounds on Chronic Periodontitis: A Clinical Review, Advances in Experimental Medicine and Biology (2021)
3. The Efficacy of Herbal Medicine in the Treatment of Recurrent Aphthous Stomatitis: A Systematic Review of Randomized Clinical Trials, Phytotherapy Research (2022)
4. Evaluating the Safety and Efficacy of Silymarin in Β-Thalassemia Patients: A Review, Hemoglobin (2015)
5. The Effects of Phytochemicals and Herbal Bio-Active Compounds on Tumour Necrosis Factor-Α in Overweight and Obese Individuals: A Clinical Review, Inflammopharmacology (2022)
6. The Effects of Nutraceuticals and Herbal Medicine on Candida Albicans in Oral Candidiasis: A Comprehensive Review, Advances in Experimental Medicine and Biology (2021)
7. Protective Effects of Silymarin on Preventing Vancomycin Nephrotoxicity in Infectious Patients: A Randomized, Double-Blinded, Placebo-Controlled, Pilot Clinical Trial, Naunyn-Schmiedeberg's Archives of Pharmacology (2024)
8. Medicinal Plants and Phytochemicals Regulating Insulin Resistance and Glucose Homeostasis in Type 2 Diabetic Patients: A Clinical Review, Advances in Experimental Medicine and Biology (2021)
Experts (# of related papers)
View all Related Experts
Mohammad Bagherniya (20)
Mohsen Minaiyan (14)
Other Related Docs
9. The Effect of Herbal Medicine and Natural Bioactive Compounds on Plasma Adiponectin: A Clinical Review, Advances in Experimental Medicine and Biology (2021)
10. Protective Effects of Curcumin in the Reproductive System: Anti-Toxic, Semen Cryopreservative, and Contraceptive Actions, Advances in Experimental Medicine and Biology (2021)
11. Efficacy of the Plantago Major L. Syrup on Radiation Induced Oral Mucositis in Head and Neck Cancer Patients: A Randomized, Double Blind, Placebo-Controlled Clinical Trial, Complementary Therapies in Medicine (2020)
12. The Efficacy of Oral Hydrogel Containing Hyaluronic Acid, Polyvinylpyrrolidone, and Glycyrrhizin for Prevention and Treatment of Oral Mucositis Induced by Chemotherapy, Journal of Isfahan Medical School (2021)
13. Medicinal Plants and Bioactive Natural Products As Inhibitors of Nlrp3 Inflammasome, Phytotherapy Research (2021)
14. Antioxidant Effect of Ziziphus Vulgaris, Portulaca Oleracea, Berberisintegerima and Gundelia Tournefortti on Lipid Peroxidation, Hb Glycosylation and Red Blood Cell Hemolysis, Journal of Medicinal Plants (2011)
15. The Effects of Medicinal Plants and Bioactive Natural Compounds on Homocysteine, Molecules (2021)
16. Combined Therapy of Silymarin and Desferrioxamine in Patients With Β-Thalassemia Major: A Randomized Double-Blind Clinical Trial, Fundamental and Clinical Pharmacology (2009)
17. The Effects of Curcumin in the Treatment of Gingivitis: A Systematic Review of Clinical Trials, Advances in Experimental Medicine and Biology (2021)
18. An Overview of the Uses of Propolis for Oral Health, Advancements in Life Sciences (2023)
19. Preventive Effects of Achillea Millefolium, Rosa Damascena and Origanum Majorana Hydroalcoholic Extracts on Breast Cancer in Female Mice, Current Cancer Therapy Reviews (2023)
20. Curcumin Supplementation Prevents Cisplatin-Induced Nephrotoxicity: A Randomized, Double-Blinded, and Placebo-Controlled Trial, Research in Pharmaceutical Sciences (2023)
21. Silymarin Impacts on Immune System As an Immunomodulator: One Key for Many Locks, International Immunopharmacology (2017)
22. Immunomodulatory Effects of Silymarin in Patients With Β-Thalassemia Major, International Immunopharmacology (2013)
23. Inhibition of Apoptosis and Proliferation in T Cells by Immunosuppressive Silymarine, Iranian Journal of Allergy, Asthma and Immunology (2017)
24. Natural and Herbal Compounds Targeting Breast Cancer, a Review Based on Cancer Stem Cells, Iranian Journal of Basic Medical Sciences (2020)
25. The Clinical Use of Curcumin on Neurological Disorders: An Updated Systematic Review of Clinical Trials, Phytotherapy Research (2021)
26. Anti-Inflammatory and Analgesic Properties of Heracleum Persicum Essential Oil and Hydroalcoholic Extract in Animal Models, Journal of Ethnopharmacology (2009)
27. Cytotoxic Evaluations of Iranian Conifers on Cancer Ells, Pharmaceutical Biology (2005)
28. Antioxidant Effects of Hydroalcoholic and Polyphenolic Extracts of Peucedanum Pastinacifolium Boiss. and Hausskn, Research in Pharmaceutical Sciences (2016)
29. Immunoregulatory Effects of Silymarin on Proliferation and Activation of Th1 Cells Isolated From Newly Diagnosed and Ifn-ß 1B -Treated Ms Patients, Inflammation (2019)
30. Silymarin Inhibits Cell Cycle Progression and Mtor Activity in Activated Human T Cells: Therapeutic Implications for Autoimmune Diseases, Basic and Clinical Pharmacology and Toxicology (2013)
31. Bioactivity-Guided Isolation of New Antiproliferative Compounds From Juniperus Foetidissima Willd, Natural Product Research (2016)
32. Effects of Cinnamon Oil and Its Main Constituents, Cinnamic Acid and Cinnamaldehyde, on 1-Methyl-4-Phenyl-1,2,3,6-Tetrahydropyridine-Induced Neurodegeneration in Pc-12 Cells; [Efectos Del Aceite De Canela Y Sus Principales Componentes, Acido Cinamico Y Cinamaldehido En La Neurodegeneracion Inducida Por 1-Metil-4-Fenil-1,2,3,6-Tetrahidropiridina En Celulas Pc 12], Boletin Latinoamericano y del Caribe de Plantas Medicinales y Aromaticas (2023)
33. Medicinal Plants, Effective Plant Compounds (Compositions) and Their Effects on Stomach Cancer, International Journal of Preventive Medicine (2017)
34. Role of Peroxisome Proliferator-Activated Receptor Alpha and Gamma in Antiangiogenic Effect of Pomegranate Peel Extract, Iranian Journal of Basic Medical Sciences (2016)
35. Anti-Nociceptive and Anti-Inflammatory Effects of Ferulago Angulata, Immunopathologia Persa (2020)
36. Saffron (Crocus Sativus) As a Middle East Herb: Traditional and Modern Medicinal Applications, Ancient and Traditional Foods, Plants, Herbs and Spices used in the Middle East (2023)
37. Chemical Composition and Antibacterial Activities of Sumac Fruit (Rhus Coriaria) Essential Oil on Dental Caries Pathogens, Open Microbiology Journal (2020)
38. A Review of the Antifungal Properties of Medicinal Herbs, Journal of Isfahan Medical School (2015)
39. Preventive Care for Gastrointestinal Disorders; Role of Herbal Medicines in Traditional Persian Medicine, Jundishapur Journal of Natural Pharmaceutical Products (2015)
40. Cytotoxic Activities of Euphorbia Kopetdaghi Against Ovcar-3 and Ej-138 Cell Lines, Journal of HerbMed Pharmacology (2015)
41. A Systematic Review on Safety and Drug Interaction of Herbal Therapy in Hyperlipidemia: A Guide for Internist, Acta Biomedica (2015)
42. New Concepts in Nutraceuticals As Alternative for Pharmaceuticals, International Journal of Preventive Medicine (2014)
43. The Role of Curcumin in Modulating Circular Rnas and Long Non-Coding Rnas in Cancer, Clinical and Translational Oncology (2024)
44. A Review on the Phytochemistry, Pharmacology, and Therapeutic Effects of Rheum Ribes, Advances in Experimental Medicine and Biology (2021)
45. Antioxidant, Antimicrobial and Antiviral Properties of Herbal Materials, Antioxidants (2020)
46. Cytoprotective Effect of Hydroalcoholic Extract of Pinus Eldarica Bark Against H2o2-Induced Oxidative Stress in Human Endothelial Cells, Iranian Biomedical Journal (2016)
47. Ethnobotanical Identification of Medicinal Plants Effective on Toothache in Shiraz, South Iran, Der Pharmacia Lettre (2015)
48. The Effect of Oral Zinc Sulfate on Prevention of Chemotherapy-Induced Oral Mucositis in Breast Cancer Patients Treated With Adriamycin and Cyclophosphamide; a Double-Blind Randomized Clinical Trial, Journal of Nephropharmacology (2023)
49. Cytotoxic Effects of the Extracts of Iranian Taxus Baccata and Cupressus Horizentalis on Cancer Cells, Iranian Journal of Pharmaceutical Research (2003)
50. Immunosuppressive Effect of Silymarin on Mitogen-Activated Protein Kinase Signalling Pathway: The Impact on T Cell Proliferation and Cytokine Production, Basic and Clinical Pharmacology and Toxicology (2013)