Isfahan University of Medical Sciences

Science Communicator Platform

Stay connected! Follow us on X network (Twitter):
Share this content! On (X network) By
Evaluation of Structural, Mechanical, and Cellular Behavior of Electrospun Poly-3-Hydroxybutyrate Scaffolds Loaded With Glucosamine Sulfate to Develop Cartilage Tissue Engineering Publisher



Shahali Z1 ; Karbasi S2 ; Avadi MR1 ; Semnani D3 ; Naghash Zargar E3 ; Hashemibeni B4
Authors
Show Affiliations
Authors Affiliations
  1. 1. Department of Medical Nanotechnology, Faculty of Advanced Sciences & Technology, Pharmaceutical Sciences Branch, Islamic Azad University, Tehran, Iran
  2. 2. Department of Biomaterials and Tissue Engineering, School of Advanced Technologies in Medicine, Isfahan University of Medical Sciences, Isfahan, Iran
  3. 3. Department of Textile Engineering, Isfahan University of Technology, Isfahan, Iran
  4. 4. Department of Anatomical Sciences and Molecular Biology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran

Source: International Journal of Polymeric Materials and Polymeric Biomaterials Published:2017


Abstract

Considering the role of glucosamine sulfate (GS) in the biosynthetic pathways of chondrocytes, an attempt was made to design an electrospun poly-3-hydroxybutyrate (PHB) scaffold loaded with GS to develop cartilage tissue engineering. The study was initiated using the optimal electrospun scaffold conditions for the synthesis of PHB/GS. The resulting scaffolds have shown excellent pore architectures and mechanical behavior compared to pure PHB. UV spectrophotometric analysis, for the evaluation of the GS release behavior, showed zero-order kinetics release. In vitro results indicated excellent cell viability, cell adhesion, and cell penetration of PHB/GS scaffolds compared to pure PHB. © 2017 Taylor & Francis.
Related Docs
View other Related Docs
1. Effects of Decellularized Extracellular Matrix on Polyhydroxybutyrate Electrospun Scaffolds for Cartilage Tissue Engineering, Polymer-Plastics Technology and Materials (2023)
2. Evaluation of the Effects of Glucosamine Sulfate on Poly(3- Hydroxybutyrate) -Chitosan/Carbon Nanotubes Electrospun Scaffold for Cartilage Tissue Engineering Applications, Polymer-Plastics Technology and Materials (2022)
3. Evaluation of the Effects of Decellularized Wharton Jelly Nanoparticles on Polyhydroxy Butyrate-Chitosan Electrospun Scaffolds for Cartilage Tissue Engineering Applications, Journal of Polymers and the Environment (2025)
4. Electrospun Poly(Hydroxybutyrate)/Chitosan Blend Fibrous Scaffolds for Cartilage Tissue Engineering, Journal of Applied Polymer Science (2016)
5. Modified Poly(3-Hydroxybutyrate)-Based Scaffolds in Tissue Engineering Applications: A Review, International Journal of Biological Macromolecules (2021)
6. Evaluation of the Effects of Hyaluronic Acid on Poly (3-Hydroxybutyrate)/Chitosan/Carbon Nanotubes Electrospun Scaffold: Structure and Mechanical Properties, Polymer-Plastics Technology and Materials (2019)
7. Evaluation of the Effects of Cartilage Decellularized Ecm in Optimizing Phb-Chitosan-Hnt/Chitosan-Ecm Core-Shell Electrospun Scaffold: Physicochemical and Biological Properties, Biomaterials Advances (2025)
8. Preparing Nanocomposite Fibrous Scaffolds of P3hb/Nha for Bone Tissue Engineering, 2010 17th Iranian Conference of Biomedical Engineering, ICBME 2010 - Proceedings (2010)
Experts (# of related papers)
View all Related Experts
Saeed Karbasi (74)
Mohammad Rafienia (40)
Other Related Docs
9. Evaluation of the Structural Properties and Cellular Behavior of Electrospun Poly(Hydroxybutyrate)/Chitosan Blend Scaffolds for Cartilage Tissue Engineering, Journal of Isfahan Medical School (2015)
10. Cartilage Particles Can Promote Chondrogenesis of Adipose-Derived Stromal Cells on Poly(Ε-Caprolactone)/Fibrin Hybrid Constructs Prepared Via Sandwich Model, Journal of Biomimetics, Biomaterials and Biomedical Engineering (2020)
11. Evaluation of the Effects of Decellularized Extracellular Matrix Nanoparticles Incorporation on the Polyhydroxybutyrate/Nano Chitosan Electrospun Scaffold for Cartilage Tissue Engineering, International Journal of Biological Macromolecules (2024)
12. Evaluation of the Effects of Β-Tricalcium Phosphate on Physical, Mechanical and Biological Properties of Poly (3-Hydroxybutyrate)/Chitosan Electrospun Scaffold for Cartilage Tissue Engineering Applications, Materials Technology (2019)
13. A Core-Shell Electrospun Scaffold of Polyhydroxybutyrate-Starch/Halloysite Nanotubes Containing Extracellular Matrix and Chitosan for Articular Cartilage Tissue Engineering Application, Journal of Polymers and the Environment (2023)
14. Evaluation of the Effects of Starch on Polyhydroxybutyrate Electrospun Scaffolds for Bone Tissue Engineering Applications, International Journal of Biological Macromolecules (2021)
15. Evaluating the Osteogenic Properties of Polyhydroxybutyrate-Zein/Multiwalled Carbon Nanotubes (Mwcnts) Electrospun Composite Scaffold for Bone Tissue Engineering Applications, International Journal of Biological Macromolecules (2024)
16. Electrospun Halloysite Nanotube Loaded Polyhydroxybutyrate-Starch Fibers for Cartilage Tissue Engineering, International Journal of Biological Macromolecules (2022)
17. A Comparative Study of Articular Chondrocytes Metabolism on a Biodegradable Polyesterurethane Scaffold and Alginate in Different Oxygen Tension and Ph, IFMBE Proceedings (2009)
18. Effects of Cartilage Acellular Solubilised Ecm on Physicomechanical and Biological Properties of Polycaprolactone/Fibrin Hybrid Scaffold Fabricated by 3D-Printing and Salt-Leaching Methods, Materials Technology (2022)
19. Casein Release and Characterization of Electrospun Nanofibres for Cartilage Tissue Engineering, Bulletin of Materials Science (2022)
20. Evaluation of the Effects of Zein Incorporation on Physical, Mechanical, and Biological Properties of Polyhydroxybutyrate Electrospun Scaffold for Bone Tissue Engineering Applications, International Journal of Biological Macromolecules (2023)
21. Polycaprolactone-Chitosan/Multi-Walled Carbon Nanotube: A Highly Strengthened Electrospun Nanocomposite Scaffold for Cartilage Tissue Engineering, International Journal of Biological Macromolecules (2022)
22. Evaluation of the Effects of Chitosan Nanoparticles on Polyhydroxy Butyrate Electrospun Scaffolds for Cartilage Tissue Engineering Applications, International Journal of Biological Macromolecules (2023)
23. Evaluation of Mechanical Properties and Cell Viability of Poly (3-Hydroxybutyrate)-Chitosan/Al2o3nanocomposite Scaffold for Cartilage Tissue Engineering, Journal of Medical Signals and Sensors (2019)
24. Biological Evaluation of the Effects of Hyaluronic Acid on Poly (3-Hydroxybutyrate) Based Electrospun Nanocomposite Scaffolds for Cartilage Tissue Engineering Application, Materials Technology (2020)
25. Hybrid and Composite Scaffolds Based on Extracellular Matrices for Cartilage Tissue Engineering, Tissue Engineering - Part B: Reviews (2019)
26. Scaffold Percolative Efficiency: In Vitro Evaluation of the Structural Criterion for Electrospun Mats, Journal of Materials Science: Materials in Medicine (2010)
27. Evaluation of the Effects of Decellularized Umbilical Cord Wharton's Jelly Ecm on Polyhydroxy Butyrate Electrospun Scaffolds: A New Strategy for Cartilage Tissue Engineering, Materials Today Chemistry (2024)
28. Fabrication and Assessment of a Novel Hybrid Scaffold Consisted of Polyurethane-Gellan Gum-Hyaluronic Acid-Glucosamine for Meniscus Tissue Engineering, International Journal of Biological Macromolecules (2022)
29. Incorporation of Chitosan Nanoparticles Into Silk Fibroin-Based Porous Scaffolds: Chondrogenic Differentiation of Stem Cells, International Journal of Polymeric Materials and Polymeric Biomaterials (2016)
30. Incorporation of Zeolite and Silica Nanoparticles Into Electrospun Pva/Collagen Nanofibrous Scaffolds: The Influence on the Physical, Chemical Properties and Cell Behavior, International Journal of Polymeric Materials and Polymeric Biomaterials (2016)
31. Polyhydroxybutyrate-Starch/Carbon Nanotube Electrospun Nanocomposite: A Highly Potential Scaffold for Bone Tissue Engineering Applications, International Journal of Biological Macromolecules (2022)
32. Comparing the Effect of Silk Fibroin-Based Scaffolds on Differentiation of Rabbit Chondrocytes, Journal of Isfahan Medical School (2014)
33. Chondrogenesis of Human Adipose-Derived Mesenchymal Stromal Cells on the [Devitalized Costal Cartilage Matrix/Poly(Vinyl Alcohol)/Fibrin] Hybrid Scaffolds, European Polymer Journal (2019)
34. Biodegradation and Cellular Evaluation of Aligned and Random Poly (3-Hydroxybutyrate)/Chitosan Electrospun Scaffold for Nerve Tissue Engineering Applications, Materials Technology (2020)
35. Evaluation of Hydrostatic Pressure on Metabolism of the Articular Chondrocytes Seeded on Biodegradable Polyurethane As Tissue Engineering Scaffold, IFMBE Proceedings (2007)
36. Evaluation of Mg63 Cells Behavior With Electrospun Nanocomposite Scaffolds of Polycaprolactone and Carbon Quantum Dot Containing Captopril for Bone Tissue Engineering, Journal of Knowledge and Health in Basic Medical Sciences (2020)
37. Evaluation of the Effects of Halloysite Nanotubes on Physical, Mechanical, and Biological Properties of Polyhydroxy Butyrate Electrospun Scaffold for Cartilage Tissue Engineering Applications, Journal of Polymers and the Environment (2024)
38. Adipose-Derived Stem Cells Growth and Proliferation Enhancement Using Poly (Lactic-Co-Glycolic Acid) (Plga)/Fibrin Nanofiber Mats, Journal of Applied Biotechnology Reports (2021)
39. Silk Fibroin-Chondroitin Sulfate-Alginate Porous Scaffolds: Structural Properties and in Vitro Studies, Journal of Applied Polymer Science (2014)
40. Porous Starch/Cellulose Nanofibers Composite Prepared by Salt Leaching Technique for Tissue Engineering, Carbohydrate Polymers (2014)
41. Does the Tissue Engineering Architecture of Poly(3-Hydroxybutyrate) Scaffold Affects Cell-Material Interactions?, Journal of Biomedical Materials Research - Part A (2012)
42. Characterization of Poly(Ε-Caprolactone)/Extracellular Matrix Nanofibers Composite Scaffold for Tissue Engineering, Journal of Isfahan Medical School (2019)
43. A Comparative Study of Articular Chondrocytes Metabolism on a Biodegradable Polyesterurethane Scaffold and Alginate Beads in Different Oxygen Tension and Ph, Journal of Isfahan Medical School (2009)
44. Chondrogenesis of Mesenchymal Stromal Cells on the 3D Printed Polycaprolactone/Fibrin/Decellular Cartilage Matrix Hybrid Scaffolds in the Presence of Piascledine, Journal of Biomaterials Science, Polymer Edition (2024)
45. Synthetic Electrospun Nanofibers As a Supportive Matrix in Osteogenic Differentiation of Induced Pluripotent Stem Cells, Journal of Biomaterials Science, Polymer Edition (2022)
46. A Comparison Between Cell Viability of Chondrocytes on a Biodegradable Polyester Urethane Scaffold and Alginate Beads in Different Oxygen Tension and Ph, Iranian Polymer Journal (English Edition) (2005)
47. Fabrication and Characterization of Chitosan-Gelatin/Single-Walled Carbon Nanotubes Electrospun Composite Scaffolds for Cartilage Tissue Engineering Applications, Polymers for Advanced Technologies (2022)
48. Evaluation Avocado Soybean Unsaponifiables Loaded in Poly (Lactic-Co-Glycolic) Acid/Avocado Soybean Unsaponifiables-Fibrin Nanoparticles Scaffold (New Delivery System) Is an Effective Factor for Tissue Engineering, Advanced Biomedical Research (2021)
49. Comparison of Poly(Lactic-Co-Glycolic Acid) and Poly(Lactic-Co-Glycolic Acid)/Hyaluronic Acid Based Scaffolds for Chondrogenesis of Human Adipose-Derived Stem Cells by Avocado/Soybean Unsaponifiables, Journal of Kerman University of Medical Sciences (2021)
50. Extracellular Matrix Coated Three-Dimensional-Printed Polycaprolactone Scaffolds Containing Curcumin for Cartilage Tissue Engineering Applications, Journal of Bioactive and Compatible Polymers (2024)