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Preparation, Process Optimization and Characterization of Core-Shell Polyurethane/Chitosan Nanofibers As a Potential Platform for Bioactive Scaffolds Publisher

Summary: Scientists report core-shell nanofibers may improve tissue scaffolds, offering new options for medical repairs. #TissueEngineering #Biomedical

Maleknia L1 ; Dilamian M2 ; Pilehrood M3 ; Sadeghialiabadi H4 ; Hekmati A5
Authors

Source: Research in Pharmaceutical Sciences Published:2018


Abstract

In this paper, polyurethane (PU), chitosan (Cs)/polyethylene oxide (PEO), and core-shell PU/Cs nanofibers were produced at the optimal processing conditions using electrospinning technique. Several methods including SEM, TEM, FTIR, XRD, DSC, TGA and image analysis were utilized to characterize these nanofibrous structures. SEM images exhibited that the core-shell PU/Cs nanofibers were spun without any structural imperfections at the optimized processing conditions. TEM image confirmed the PU/Cs core-shell nanofibers were formed apparently. It that seems the inclusion of Cs/PEO to the shell, did not induce the significant variations in the crystallinity in the core-shell nanofibers. DSC analysis showed that the inclusion of Cs/PEO led to the glass temperature of the composition increased significantly compared to those of neat PU nanofibers. The thermal degradation of core-shell PU/Cs was similar to PU nanofibers degradation due to the higher PU concentration compared to other components. It was hypothesized that the core-shell PU/Cs nanofibers can be used as a potential platform for the bioactive scaffolds in tissue engineering. Further biological tests should be conducted to evaluate this platform as a three dimensional scaffold with the capabilities of releasing the bioactive molecules in a sustained manner. © 2018 Herpetologist's League Inc. All rights reserved.
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