Isfahan University of Medical Sciences

Science Communicator Platform

Stay connected! Follow us on X network (Twitter):
Share this content! On (X network) By
Potential of Novel Electrospun Core-Shell Structured Polyurethane/Starch (Hyaluronic Acid) Nanofibers for Skin Tissue Engineering: In Vitro and in Vivo Evaluation Publisher Pubmed



Movahedi M1 ; Asefnejad A1 ; Rafienia M2 ; Khorasani MT3
Authors
Show Affiliations
Authors Affiliations
  1. 1. Biomedical Engineering (Biomaterials) Department, Islamic Azad University - Science and Research Branch, Tehran, Iran
  2. 2. Department of Biomaterials, Tissue Engineering and Nanotechnology, School of Advanced Medical Technologies, Isfahan University of Medical Sciences, Isfahan, Iran
  3. 3. Biomaterial Department of Iran Polymer and Petrochemical Institute, P.O. Box 14965/159, Tehran, Iran

Source: International Journal of Biological Macromolecules Published:2020


Abstract

The biomaterials with excellent biocompatibility and biodegradability ¬can lead to satisfactory wound healing. In this study, core-shell structured PU (polyurethane)/St (Starch) and PU/St (Hyaluronic Acid (HA)) nanofibers were fabricated with coaxial electrospinning technique. The morphology characterization of the core-shell structure of nanofibers was investigated by scanning electron microscopy (SEM) and transmission electron microscopy (TEM) images. Contact-angle measurements were confirmed the core/shell structure of the electrospun nanofibers with shell and core feed rates of 0.675 L/min and <0.135 L/min, respectively. The average fiber diameter values were calculated for polyurethane nanofibers (836 ± 172.13 nm), PU/St nanofibers (612 ± 93.21 nm) and PU/St (HA) nanofibers (428 ± 78.32 nm). The average porosity values of scaffolds were determined for PU (1.251 ± 0.235 μm), PU/St (1.734 ± 0.284 μm) and PU/St (HA) (3.186 ± 0.401 μm). The core-shell PU/St and PU/St (HA) nanofibers were evaluated in vitro by using mouse fibroblasts (L929) cells. Cell morphology and viability results were exhibited significant enhancement in cell promoting and cell attachment. Furthermore, in vivo studies was indicated Core-shell PU/St (HA) wound dressing can be an appropriate candidate for skin tissue engineering and wound healing. © 2018
Related Docs
View other Related Docs
1. A Novel Bilayer Wound Dressing Composed of a Dense Polyurethane/Propolis Membrane and a Biodegradable Polycaprolactone/Gelatin Nanofibrous Scaffold, Scientific Reports (2020)
2. Novel Electrospun Polyurethane Scaffolds Containing Bioactive Glass Nanoparticles, Bioinspired, Biomimetic and Nanobiomaterials (2020)
3. Core-Shell Nanofibers Containing L-Arginine Stimulates Angiogenesis and Full Thickness Dermal Wound Repair, International Journal of Pharmaceutics (2024)
4. Coaxial Electrospun Angiogenic Nanofiber Wound Dressing Containing Advanced Platelet Rich-Fibrin, International Journal of Biological Macromolecules (2022)
5. Mupirocin Loaded Core-Shell Pluronic-Pectin-Keratin Nanofibers Improve Human Keratinocytes Behavior, Angiogenic Activity and Wound Healing, International Journal of Biological Macromolecules (2023)
6. An in Vitro and in Vivo Study of Electrospun Polyvinyl Alcohol/Chitosan/Sildenafil Citrate Mat on 3D-Printed Polycaprolactone Membrane As a Double Layer Wound Dressing, International Journal of Biological Macromolecules (2024)
7. An in Vitro and in Vivo Study of Pcl/Chitosan Electrospun Mat on Polyurethane/Propolis Foam As a Bilayer Wound Dressing, Biomaterials Advances (2022)
8. Optimization and Characterization of Polyhydroxybutyrate/Lignin Electro-Spun Scaffolds for Tissue Engineering Applications, International Journal of Biological Macromolecules (2022)
Experts (# of related papers)
View all Related Experts
Saeed Karbasi (74)
Mohammad Rafienia (44)
Other Related Docs
9. Synthetic-Based Blended Electrospun Scaffolds in Tissue Engineering Applications, Journal of Materials Science (2022)
10. A Hybrid 3D-Printed and Electrospun Bilayer Pharmaceutical Membrane Based on Polycaprolactone/Chitosan/Polyvinyl Alcohol for Wound Healing Applications, International Journal of Biological Macromolecules (2024)
11. Sustained Release Investigation of Curcumin and Ciprofloxacin on Coaxial Electrospun Nanocomposite Scaffold of Poly (3-Hydroxybutyrate)-Poly Glycerol Sebacate: An Approach for Skin Regeneration, Emergent Materials (2024)
12. Platelet Rich Fibrin Containing Nanofibrous Dressing for Wound Healing Application: Fabrication, Characterization and Biological Evaluations, Biomaterials Advances (2022)
13. Electrospinning of Aligned Medical Grade Polyurethane Nanofibres and Evaluation of Cell-Scaffold Interaction Using Shed Stem Cells, Micro and Nano Letters (2017)
14. Electrospun Core-Shell Polycaprolactone/ Chitosan Nanofibrous Composite With Enhanced Curcumin Loading Capacity for Wound Healing Applications, Materials Today Chemistry (2024)
15. A Core-Shell Electrospun Scaffold of Polyhydroxybutyrate-Starch/Halloysite Nanotubes Containing Extracellular Matrix and Chitosan for Articular Cartilage Tissue Engineering Application, Journal of Polymers and the Environment (2023)
16. Fabrication and Evaluation of Hesperidin Loaded Polyacrylonitrile/Polyethylene Oxide Nanofibers for Wound Dressing Application, Journal of Biomaterials Science, Polymer Edition (2021)
17. Preparation, Process Optimization and Characterization of Core-Shell Polyurethane/Chitosan Nanofibers As a Potential Platform for Bioactive Scaffolds, Research in Pharmaceutical Sciences (2018)
18. Comparing the Wound Healing Effect of a Controlled Release Wound Dressing Containing Curcumin/Ciprofloxacin and Simvastatin/Ciprofloxacin in a Rat Model: A Preclinical Study, Journal of Biomedical Materials Research - Part A (2022)
19. Platelet Rich Fibrin Containing Nanofibrous Dressing for Wound Healing Application: Fabrication, Characterization and Biological Evaluations, Materials Science and Engineering C (2021)
20. Novel Electrospun Polyvinyl Alcohol/Chitosan/Polycaprolactone-Diltiazem Hydrochloride Nanocomposite Membranes for Wound Dressing Applications, Emergent Materials (2024)
21. Preparation of Fibrin/Poly Vinyl Alcohol Electrospun Nanofibers Scaffold for Tissue Engineering Applications, Journal of Isfahan Medical School (2016)
22. Characterization of Silk/Poly 3-Hydroxybutyrate-Chitosan-Multi-Walled Carbon Nanotube Micro-Nano Scaffold: A New Hybrid Scaffold for Tissue Engineering Applications, Journal of Medical Signals and Sensors (2018)
23. Synthesis of Polyurethane/Hyaluronic Acid/Royal Jelly Electrospun Scaffold and Evaluating Its Properties for Wound Healing, Journal of Mazandaran University of Medical Sciences (2021)
24. Design and Fabrication of Poly (Glycerol Sebacate)-Based Fibers for Neural Tissue Engineering: Synthesis, Electrospinning, and Characterization, Polymers for Advanced Technologies (2019)
25. Arginine Functionalized Bacterial Cellulose Nanofibers Containing Gel As an Effective Wound Dressing: In Vitro and in Vivo Evaluation, Current Drug Delivery (2018)
26. Preparation of a Biomimetic Bi-Layer Chitosan Wound Dressing Composed of A-Prf/Sponge Layer and L-Arginine/Nanofiber, Carbohydrate Polymers (2022)
27. Delivery of Antibacterial Agents for Wound Healing Applications Using Polysaccharide-Based Scaffolds, Journal of Drug Delivery Science and Technology (2023)
28. A Propolis Enriched Polyurethane-Hyaluronic Acid Nanofibrous Wound Dressing With Remarkable Antibacterial and Wound Healing Activities, International Journal of Biological Macromolecules (2020)
29. Preparation and Evaluation of Poly Glycerol Sebacate/Poly Hydroxy Butyrate Core-Shell Electrospun Nanofibers With Sequentially Release of Ciprofloxacin and Simvastatin in Wound Dressings, Polymers for Advanced Technologies (2018)
30. Evaluation of the Effects of Starch on Polyhydroxybutyrate Electrospun Scaffolds for Bone Tissue Engineering Applications, International Journal of Biological Macromolecules (2021)
31. Pdgf and Vegf-Releasing Bi-Layer Wound Dressing Made of Sodium Tripolyphosphate Crosslinked Gelatin-Sponge Layer and a Carrageenan Nanofiber Layer, International Journal of Biological Macromolecules (2023)
32. Electrospun Halloysite Nanotube Loaded Polyhydroxybutyrate-Starch Fibers for Cartilage Tissue Engineering, International Journal of Biological Macromolecules (2022)
33. Electrospun Polyurethane-Gelatin Composite: A New Tissue-Engineered Scaffold for Application in Skin Regeneration and Repair of Complex Wounds, ACS Biomaterials Science and Engineering (2020)
34. In Vitro and in Vivo Performance of a Propolis-Coated Polyurethane Wound Dressing With High Porosity and Antibacterial Efficacy, Colloids and Surfaces B: Biointerfaces (2019)
35. A Novel Wound Dressing Nanofiber With Anti-Inflammatory and Anti-Bacterial Drugs Release for Skin Wound Healing, Journal of Isfahan Medical School (2019)
36. Comparison of Physical, Mechanical and Biological Effects of Leucocyte-Prf and Advanced-Prf on Polyacrylamide Nanofiber Wound Dressings: In Vitro and in Vivo Evaluations, Biomaterials Advances (2022)
37. Osteogenic Potential of Phb-Lignin/Cellulose Nanofiber Electrospun Scaffold As a Novel Bone Regeneration Construct, International Journal of Biological Macromolecules (2023)
38. Characterization of Poly(Ε-Caprolactone)/Extracellular Matrix Nanofibers Composite Scaffold for Tissue Engineering, Journal of Isfahan Medical School (2019)
39. In Vitro Hemocompatibility and Cytocompatibility of a Three-Layered Vascular Scaffold Fabricated by Sequential Electrospinning of Pcl, Collagen, and Plla Nanofibers, Journal of Biomaterials Applications (2016)
40. Physical and Biological Properties of Blend-Electrospun Polycaprolactone/Chitosan-Based Wound Dressings Loaded With N-Decyl-N, N-Dimethyl-1-Decanaminium Chloride: An in Vitro and in Vivo Study, Journal of Biomedical Materials Research - Part B Applied Biomaterials (2020)
41. Development of Electrospun Poly (Vinyl Alcohol)-Based Bionanocomposite Scaffolds for Bone Tissue Engineering, Journal of Biomedical Materials Research - Part A (2018)
42. Incorporation of Inorganic Bioceramics Into Electrospun Scaffolds for Tissue Engineering Applications: A Review, Ceramics International (2022)
43. Effects of Multi-Wall Carbon Nano-Tubes (Mwnts) on Structural and Mechanical Properties of Electrospun Poly(3-Hydroxybutyrate) Scaffold for Tissue Engineering Applications, Scientia Iranica (2016)
44. Characterization and Biological Evaluation of New Plga/Fibrin/Lignin Biocomposite Electrospun Scaffolds, Physica Scripta (2023)
45. Nano/Micro Hybrid Scaffold of Pcl or P3hb Nanofibers Combined With Silk Fibroin for Tendon and Ligament Tissue Engineering, Journal of Applied Biomaterials and Functional Materials (2015)
46. Plasma Surface Modification of Electrospun Polyhydroxybutyrate (Phb) Nanofibers to Investigate Their Performance in Bone Tissue Engineering, International Journal of Biological Macromolecules (2023)
47. Evaluation of the Effects of Multiwalled Carbon Nanotubes on Electrospun Poly(3-Hydroxybutirate) Scaffold for Tissue Engineering Applications, Journal of Porous Materials (2018)
48. Controlled Release of Metronidazole Benzoate From Poly Ε-Caprolactone Electrospun Nanofibers for Periodontal Diseases, European Journal of Pharmaceutics and Biopharmaceutics (2010)
49. Potential of an Electrospun Composite Scaffold of Poly (3-Hydroxybutyrate)-Chitosan/Alumina Nanowires in Bone Tissue Engineering Applications, Materials Science and Engineering C (2019)
50. Biological Evaluation of the Effects of Hyaluronic Acid on Poly (3-Hydroxybutyrate) Based Electrospun Nanocomposite Scaffolds for Cartilage Tissue Engineering Application, Materials Technology (2020)