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Trimetazidine As a Modifier of Chemotherapy-Induced Cardiovascular Redox-Homeostasis Disturbances Publisher



Avagimyan A1 ; Heshmatghahdarijani K2 ; Kakturskiy L3
Authors
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Authors Affiliations
  1. 1. Yerevan State Medical University after M. Heratsi, Yerevan, Armenia
  2. 2. Isfahan University of Medical Sciences, Isfahan, Iran
  3. 3. Avtsyn Research Institute of Human Morphology, Moscow, Russian Federation

Source: Kardiologija v Belarusi Published:2022


Abstract

Introduction. Our research was determined to investigate the Adriamycin + Cyclophosphamide (AC)-mode of chemotherapy-related disturbances of cardiovascular (CV) homeostasis, and possibility of trimetazidine (TMZ)-induced cardioprotection. Purpose. Assess oxidative state of myocardium during AC-mode of chemotherapy administration, and justification of trimetazidine prescription among under-treatment and post-treatment cancer patient. Materials and methods. For this study, 80 inbred Wistar rats were randomly divided into four equal experimental groups. A model of lipid peroxidation (LPO)-induced myocardial injury, was attained via doxorubicin and cyclophosphamide co-administration. Trimetazidine was used as a probable limiter of heart and vessels morpho-functional homeostasis aggravations. Results. The markers of redox-balance, were determined and assessed. The data obtained showed that this TMZ modified the intensification of lipid peroxidation. Conclusions: 1. AC-mode of chemotherapy has LPO-stimulating and antioxidant-limiting impact. 2. TMZ provide statistically significant and valuable normalization of redox-homeostasis. © 2022, Professionalnye Izdaniya. All rights reserved.
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