Doxorubicin and Cyclophosphamide Mode of Chemotherapy-Related Cardiomyopathy: Review of Preclinical Model

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Doxorubicin and Cyclophosphamide Mode of Chemotherapy-Related Cardiomyopathy: Review of Preclinical Model Publisher Pubmed

Avagimyan A^{1, 7} ; Kakturskiy L² ; Pogosova N³ ; Ottaviani G⁵ ; Rizzo M⁶ ; Sarrafzadegan N^{1, 7}

Source: Current problems in cardiology Published:2025

Abstract

Over the past 70 years, there has been extensive research focused on preventing chemotherapy-related cardiovascular complications. However, the current state of cardio-oncology research has raised more questions than answers. Experimental studies often present data that are difficult to compare and, at times, contradictory. One notable limitation in translating experimental findings to clinical practice is the reliance on models that administer only one chemotherapeutic drug to experimental animals, despite the common use of multidrug cancer treatments in real clinical settings. This article aims to discuss our own experience in modeling an experimental rat model of cardiomyopathy induced by the administration of two chemotherapeutic drugs, doxorubicin (adriamycin) and cyclophosphamide (AC mode of chemotherapy) - Avagimyan A., et al model, along with a subsequent review of morphological changes based on our personal archive. Copyright © 2024. Published by Elsevier Inc.

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Style	Citing Format
MLA	Avagimyan A, et al.. "Doxorubicin and Cyclophosphamide Mode of Chemotherapy-Related Cardiomyopathy: Review of Preclinical Model." Current problems in cardiology, vol. 50, no. 1, 2025, pp. 102882-.
APA	Avagimyan A, Kakturskiy L, Pogosova N, Ottaviani G, Rizzo M, Sarrafzadegan N (2025). Doxorubicin and Cyclophosphamide Mode of Chemotherapy-Related Cardiomyopathy: Review of Preclinical Model. Current problems in cardiology, 50(1), 102882-.
Chicago	Avagimyan A, Kakturskiy L, Pogosova N, Ottaviani G, Rizzo M, Sarrafzadegan N. "Doxorubicin and Cyclophosphamide Mode of Chemotherapy-Related Cardiomyopathy: Review of Preclinical Model." Current problems in cardiology 50, no. 1 (2025): 102882-.
Harvard	Avagimyan A et al. (2025) 'Doxorubicin and Cyclophosphamide Mode of Chemotherapy-Related Cardiomyopathy: Review of Preclinical Model', Current problems in cardiology, 50(1), pp. 102882-.
Vancouver	Avagimyan A, Kakturskiy L, Pogosova N, Ottaviani G, Rizzo M, Sarrafzadegan N. Doxorubicin and Cyclophosphamide Mode of Chemotherapy-Related Cardiomyopathy: Review of Preclinical Model. Current problems in cardiology. 2025;50(1):102882-.
BibTex	@article{ author = {Avagimyan A and Kakturskiy L and Pogosova N and Ottaviani G and Rizzo M and Sarrafzadegan N}, title = {Doxorubicin and Cyclophosphamide Mode of Chemotherapy-Related Cardiomyopathy: Review of Preclinical Model}, journal = {Current problems in cardiology}, volume = {50}, number = {1}, pages = {102882-}, year = {2025} }
RIS	TY - JOUR AU - Avagimyan A AU - Kakturskiy L AU - Pogosova N AU - Ottaviani G AU - Rizzo M AU - Sarrafzadegan N TI - Doxorubicin and Cyclophosphamide Mode of Chemotherapy-Related Cardiomyopathy: Review of Preclinical Model JO - Current problems in cardiology VL - 50 IS - 1 SP - 102882 EP - PY - 2025 ER -

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