Isfahan University of Medical Sciences

Science Communicator Platform

Stay connected! Follow us on X network (Twitter):
Share this content! On (X network) By
Treadmill Running Improves Spatial Memory in an Animal Model of Alzheimer's Disease Publisher Pubmed



Hoveida R1 ; Alaei H2 ; Oryan S1 ; Parivar K1 ; Reisi P2, 3
Authors
Show Affiliations
Authors Affiliations
  1. 1. Department of Biology, Faculty of Science, Islamic Azad University, Science and Research Branch, Tehran 99999, Iran
  2. 2. Department of Physiology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran
  3. 3. Biosensor Research Center, Isfahan University of Medical Sciences, Isfahan, Iran

Source: Behavioural Brain Research Published:2011


Abstract

Alzheimer's disease (AD) is a progressive neurodegenerative disease that is characterized by a decline in cognitive function and severe neuronal loss in the cerebral cortex and certain subcortical regions of the brain including nucleus basalis magnocellularis (NBM) that play an important role in learning and memory. There are few therapeutic regimens that influence the underlying pathogenic phenotypes of AD, however, of the currently available therapies, exercise training is considered to be one of the best strategies for attenuating the pathological phenotypes of AD for people with AD. Here, we sought to investigate the effect of treadmill running on spatial memory in Alzheimer-induced rats. Male Wistar rats were split into two groups namely shams (n= 7) and lesions with the lesion group subdivided further into the lesion-rest (n= 7) and lesion-exercise (n= 7). The lesion-exercise and shams were subjected to treadmill running at 17 meters per minute (m/min) for 60. min per day (min/day), 7 days per week (days/wk), for 60 days. Spatial memory was investigated using the Morris Water Maze test in the rats after 60 days of Alzheimer induction and the exercise. Our data demonstrated that spatial memory was indeed impaired in the lesion group compared with the shams. However, exercise notably improved spatial memory in the lesion-exercised rats compared to lesion-rested group. The present results suggest that spatial memory is affected under Alzheimer conditions and that treadmill running improves these effects. Our data suggested that treadmill running contributes to the alleviation of the cognitive decline in AD. © 2010 Elsevier B.V.
Other Related Docs
12. Daily Running Promotes Spatial Learning and Memory in Rats, Journal of Sports Science and Medicine (2007)
18. Chronic Running Exercise Promotes Spatial Learning and Memory in Rats, Journal of Isfahan Medical School (2007)
24. Forced Exercise Improves Passive Avoidance Memory in Morphine-Exposed Rats, Pakistan Journal of Biological Sciences (2009)
47. Treadmill Running Reverses Retention Deficit Induced by Morphine, European Journal of Pharmacology (2006)