Isfahan University of Medical Sciences

Science Communicator Platform

Stay connected! Follow us on X network (Twitter):
Share this content! On (X network) By
Antimetastatic Effects of Curcumin in Oral and Gastrointestinal Cancers Publisher



Davoodvandi A1, 2 ; Farshadi M3 ; Zare N4 ; Akhlagh SA5 ; Alipour Nosrani E6 ; Mahjoubintehran M7 ; Kangari P8 ; Sharafi SM9 ; Khan H10 ; Aschner M11 ; Baniebrahimi G12 ; Mirzaei H13
Authors
Show Affiliations
Authors Affiliations
  1. 1. Student Research Committee, Kashan University of Medical Sciences, Kashan, Iran
  2. 2. Cancer Immunology Project (CIP), Universal Scientific Education and Research Network (USERN), Tehran, Iran
  3. 3. Giamed Corp, Richmond Hill, ON, Canada
  4. 4. Faculty of Pharmacy, International Campus, Tehran University of Medical Science, Tehran, Iran
  5. 5. School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran
  6. 6. Department of Nutrition, Science and Research Branch, Islamic Azad University, Tehran, Iran
  7. 7. Department of Medical Biotechnology, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
  8. 8. Department of Tissue Engineering and Applied Cell Sciences, School of Advanced Medical Sciences and Technologies, Shiraz University of Medical Sciences, Shiraz, Iran
  9. 9. Environment Research Center, Research Institute for Primordial Prevention of Non-Communicable Disease, Isfahan University of Medical Sciences, Isfahan, Iran
  10. 10. Department of Pharmacy, Abdul Wali Khan University, Mardan, Pakistan
  11. 11. Department of Molecular Pharmacology, Albert Einstein College of Medicine, Bronx, NY, United States
  12. 12. Department of Pediatric Dentistry, School of Dentistry, Tehran University of Medical Sciences, Tehran, Iran
  13. 13. Research Center for Biochemistry and Nutrition in Metabolic Diseases, Institute for Basic Sciences, Kashan University of Medical Sciences, Kashan, Iran

Source: Frontiers in Pharmacology Published:2021


Abstract

Gastrointestinal (GI) cancers are known as frequently occurred solid malignant tumors that can cause the high rate mortality in the world. Metastasis is a significant destructive feature of tumoral cells, which directly correlates with decreased prognosis and survival. Curcumin, which is found in turmeric, has been identified as a potent therapeutic natural bioactive compound (Curcuma longa). It has been traditionally applied for centuries to treat different diseases, and it has shown efficacy for its anticancer properties. Numerous studies have revealed that curcumin inhibits migration and metastasis of GI cancer cells by modulating various genes and proteins, i.e., growth factors, inflammatory cytokines and their receptors, different types of enzymes, caspases, cell adhesion molecules, and cell cycle proteins. Herein, we summarized the antimetastatic effects of curcumin in GI cancers, including pancreatic cancer, gastric cancer, colorectal cancer, oral cancer, and esophageal cancer. © Copyright © 2021 Davoodvandi, Farshadi, Zare, Akhlagh, Alipour Nosrani, Mahjoubin-Tehran, Kangari, Sharafi, Khan, Aschner, Baniebrahimi and Mirzaei.
Other Related Docs
12. Rescue Effect of Curcumin Against Copper Toxicity, Journal of Trace Elements in Medicine and Biology (2023)
23. Inhibitory Effects of Curcumin on Aldose Reductase and Cyclooxygenase-2 Enzymes, Journal of Biomolecular Structure and Dynamics (2021)
29. Turmeric (Curcuma Longa L.) Usage in the Middle East a Comprehensive Review, Ancient and Traditional Foods, Plants, Herbs and Spices used in the Middle East (2023)
45. A Systematic Review of the Clinical Use of Curcumin for the Treatment of Osteoarthritis, Advances in Experimental Medicine and Biology (2021)