Isfahan University of Medical Sciences

Science Communicator Platform

Stay connected! Follow us on X network (Twitter):
Share this content! On (X network) By
Radiobiological Comparison of 3D Conformal and Intensity Modulated Radiation Therapy in the Treatment of Left-Sided Breast Cancer Publisher



Shanei A1 ; Amouheidari A2 ; Abedi I1 ; Kazemzadeh A3 ; Jaafari A4
Authors
Show Affiliations
Authors Affiliations
  1. 1. Faculty Member of Medical Physics Department, Isfahan University of Medical Sciences, Isfahan, Iran
  2. 2. Radiation Oncologist, Isfahan Milad Hospital, Isfahan, Iran
  3. 3. Medical Physics, Kashan University of Medical Sciences, Kashan, Iran
  4. 4. Medical Physics, Isfahan University of Medical Sciences, Isfahan, Iran

Source: International Journal of Radiation Research Published:2020


Abstract

Background: The current study aimed to compare the tumor control probability (TCP) and normal tssue complicaton probability (NTCP) of three-dimensional conformal radiaton therapy (3D-CRT) and intensity-modulated radiaton therapy (IMRT) for left-sided breast cancer using radiobiological models. Methods: This study was conducted on 30 patents with left-sided breast cancer, who were planned for 3D-CRT and 6-9 fields IMRT treatments using the PROWESS treatment planning system. The planning target volume (PTV) dose of 50 Gy was administered for the 3D-CRT and IMRT plans, respectvely. The Niemierko's equivalent uniform dose (EUD) model was utlized for the estmaton of tumor control probability (TCP) and normal tssue complicaton probability (NTCP). Results: According to the results, the mean TCP values for 3D-CRT, 6-fields IMRT, and 9-fields IMRT plans were 99.07 ±0.07, 99.24 ±0.05 and 99.28 ±0.04, respectvely, showing no statstcally significant difference. The NTCPs of the lung and heart were considerably lower in the IMRT plans, compared to those in the 3D-CRT plans. Conclusions: From the radiobiological point of view, our results indicated that 3D-CRT produces a lower NTCP for ipsilateral lung. In contrast, for TCP calculatons, there was a higher gain with IMRT plans compared to 3D-CRT plans. © 2020 Novin Medical Radiation Institute. All rights reserved.
Related Docs
View other Related Docs
1. Radiobiological Evaluation and Comparison of Treatment Plans in Two Methods of 3D Adaptive Radiation Therapy and Tomotherapy for Left Pendular Breast Cancer and the Risk of Pericarditis and Pneumonia; [ارزیابی و مقایسهی رادیوبیولوژیکی طرحهای درمان در دو روش پرتودرمانی تطبیقی سه بعدی و توموتراپی], Journal of Isfahan Medical School (2023)
2. Dosimetric Comparison of Treatment of Left Breast Cancer Using 3-Dimention Conformal Radiotherapy Technique (3D-Crt) and Intensity-Modulated Radiotherapy Technique (Imrt), Journal of Isfahan Medical School (2018)
3. Dosimetric Comparison and Tcp-Ntcp Modeling for Lung, Heart, Left Anterior Descending, and Right Coronary Artery in Left-Sided Breast Cancer Conventional and Hypofractionated Radiotherapy, International Journal of Cancer Management (2021)
4. A Dose Planning Study for Cardiac and Lung Dose Sparing Techniques in Left Breast Cancer Radiotherapy: Can Free Breathing Helical Tomotherapy Be Considered As an Alternative for Deep Inspiration Breath Hold?, Technical Innovations and Patient Support in Radiation Oncology (2023)
5. Dosimetric Comparison of Treatment of Left Breast Cancer Using 3-Dimention Conformal Radiotherapy Technique and Tomotherapy, Journal of Isfahan Medical School (2022)
6. Dosimetric Comparison of Two Methods of Three-Dimensional Conformal Radiotherapy and Helical Tomotherapy in Head and Neck Cancer Patients With Involvement of Regional Lymph Nodes, Journal of Isfahan Medical School (2023)
7. Dosiomics-Based Comparison of Dose Distributions in Nasopharyngeal Cancer Patients: 3D-Crt Versus Tomotherapy, International Journal of Radiation Research (2024)
8. Evaluation of the Lung Dose in Three-Dimensional Conformal Radiation Therapy of Left-Sided Breast Cancer: A Phantom Study, Journal of Medical Signals and Sensors (2020)
Experts (# of related papers)
View all Related Experts
Mohammad Bagher Tavakoli (15)
Daryoush Shahbazi-Gahrouei (14)
Other Related Docs
9. Evaluation of the Effects of Dental Filling Material Artifacts on Imrt Treatment Planning in Patient With Nasopharyngeal Cancer, International Journal of Radiation Research (2019)
10. A Comparative Planning Study on the Treatment of Gastric Cancer Patients With Tomotherapy, Coplanar and Non-Coplanar Three-Dimensional Conformal Radiotherapy (3D-Crt), International Journal of Radiation Research (2024)
11. Development and Implementation of a Monte Carlo Frame Work for Evaluation of Patient Specific Out- of - Field Organ Equivalent Dose, International Journal of Radiation Research (2017)
12. The Radiobiological Impact of Dental Root Filling Material in Intensity-Modulated Radiation Therapy (Imrt) in Patients With Nasopharyngeal Carcinoma, Journal of Isfahan Medical School (2019)
13. Comparison of 3D Conformal and Intensity Modulated Radiotherapy in Early Stage Oral Tongue Cancer: Dosimetric and Radiobiological Evaluation, International Journal of Radiation Research (2020)
14. The Comparison of Radiation Dosimetry of Rectal Cancer in Two Supine and Prone Positions, Journal of Isfahan Medical School (2023)
15. Dosimetric and Radiobiological Evaluation of Multiparametric Mri-Guided Dose Painting in Radiotherapy of Prostate Cancer, Journal of Medical Signals and Sensors (2017)
16. Dosimetric Comparison of Treatment of Left Breast Cancer Using Two Different Dose Schedules, Tehran University Medical Journal (2020)
17. A Radiobiological Comparison of Hypo-Fractionation Versus Conventional Fractionation for Breast Cancer 3D-Conformal Radiation Therapy, Reports of Practical Oncology and Radiotherapy (2021)
18. Investigation and Comparison of Coplanar Versus Noncoplanar Intensity-Modulated Radiation Therapy (Imrt) Techniques in Glioblastoma Multiforme Tumors, Journal of Isfahan Medical School (2018)
19. Monte Carlo Evaluation of Out-Of-Field Dose in 18 Mv Pelvic Radiotherapy Using a Simplified Female Mird Phantom, Biomedical Physics and Engineering Express (2022)
20. Estimating Radiotherapy-Induced Secondary Cancer Risk Arising From Brain Irradiation at High Energy: A Monte Carlo Study, Frontiers in Biomedical Technologies (2022)
21. Measurement of Imposed Radiation Dose and Normal Tissue Complications Probability to Lung and Heart in Patients With Mastectomy Using Two Common Tangential Radiotherapy Methods of Supraclavicular Nodes, Anterior-Posterior (Ap) and Two Parallel Opposed Fields (Pofs), Journal of Isfahan Medical School (2018)
22. Potential Implications of the Radiation-Induced Bystander Effect for Spatially Fractionated Radiotherapy: A Theoretical Simulation Study, International Journal of Radiation Research (2022)
23. Secondary Cancer Risk After Radiotherapy of Seminoma Stage One, Iranian Journal of Medical Physics (2022)
24. Nested Cnn Architecture for Three-Dimensional Dose Distribution Prediction in Tomotherapy for Prostate Cancer, Strahlentherapie und Onkologie (2025)
25. Evaluation of the Photon Dose Calculation Accuracy in Radiation Therapy of Malignant Pleural Mesothelioma, Journal of Cancer Research and Therapeutics (2018)
26. Comparison of Electromagnetic and Hadronic Models Generated Using Geant 4 With Antiproton Dose Measured in Cern, Journal of Medical Physics (2015)
27. Evaluation of the Lung Volume Changes in Patients With Breast Cancer Based on the Received Dose in the Upper and Lower Lobes of the Lung, Journal of Isfahan Medical School (2019)
28. Estimation of Cell Response in Fractionation Radiotherapy Using Different Methods Derived From Linear Quadratic Model, Radiology and Oncology (2015)
29. The Application of the Linear Quadratic Model to Compensate the Effects of Prolonged Fraction Delivery Time on a Balb/C Breast Adenocarcinoma Tumor: An in Vivo Study, International Journal of Radiation Biology (2016)
30. Optimization of Ct Slice Thickness in 3D-Crt and Imrt Planning of Low Grade Glioma, International Journal of Radiation Research (2021)
31. Monte Carlo Modeling of Skyshine Dose Distribution in Vicinity of Medical Accelerator Facilities, Journal of Isfahan Medical School (2017)
32. Development and Implementation of the Convolution Method for Photon Dose Calculation in Radiation Therapy, Journal of Isfahan Medical School (2012)
33. Evaluation of Error Doses of Treatment Planning Software Using Solid Anthropomorphic Phantom, Journal of Isfahan Medical School (2016)
34. Evaluation of the Dose Gradient Index in Various Intensity-Modulated Radiation Therapy Techniques in Patients With Optic Nerve Sheath Meningioma, Journal of Isfahan Medical School (2020)
35. Comparison of Dosimetry of Organs at Risk for the Treatment of Nasopharyngeal Cancer Using Two Methods of Helical Tomotherapy and Three Dimensional Conformal Radiation Therapy, Journal of Isfahan Medical School (2023)
36. Determination of the Neutron Contamination During Brain Radiotherapy Using a Moderated-Boron Trifluoride Detector and the Mcnp Monte Carlo Code, Radiation Protection Dosimetry (2022)
37. Review of Fast Monte Carlo Codes for Dose Calculation in Radiation Therapy Treatment Planning, Journal of Medical Signals and Sensors (2011)
38. Evaluation of Risk of Secondary Thyroid Cancer Caused by Neutron Dose Equivalent From Brain Tumor 3D-Conformal Radiation Therapy (3D-Crt), Journal of Isfahan Medical School (2020)
39. A Novel Algorithm in Radiation Dosimetry of Regular and Irregular Treatment Fields, Advanced Biomedical Research (2019)
40. Comparison of Fused Mri/Ct-Based Contouring and Ct-Based Contouring in Helical Tomotherapy for Rectal Cancer, Journal of Isfahan Medical School (2023)
41. Estimation of the Thyroid Secondary Cancer Risk on the Patient of Standard Breast External Beam Radiotherapy, Journal of Medical Signals and Sensors (2018)
42. Deep-Neural Network Approaches for Predicting 3D Dose Distribution in Intensity-Modulated Radiotherapy of the Brain Tumors, Journal of Applied Clinical Medical Physics (2024)
43. Comparison and Evaluation of Different Treatment Plans With Ifrt Field and 6 and 18 Mv Energies in Hodgkin’S Lymphoma Involvement Neck and Mediastinum, Journal of Biomedical Physics and Engineering (2018)
44. Comparison of Organs at Risk Dose in Conventional (2-Dimensional) and Conformal (3-Dimensional) Radiotherapy of Seminoma, Journal of Isfahan Medical School (2018)
45. Assessment of Imprecise Small Photon Beam Modeling by Two Treatment Planning System Algorithms, Journal of Medical Signals and Sensors (2018)
46. Three Dimensional Film Dosimetry of Photon Beam in Small Field Sizes and Beyond the Heterogeneous Regions Using a Gafchromic Films Array, Radiation Physics and Chemistry (2020)
47. Evaluation and Comparison of Target and At-Risk Organ Dosimetry in Radiation Therapy of Prostate Cancer Patients Using Three-Dimensional Conformal Radiotherapy (3D-Crt) and Intensity-Modulated Radiation Therapy (Imrt), Journal of Isfahan Medical School (2022)
48. Determining the Optimum Tumor Control Probability Model in Radiotherapy of Glioblastoma Multiforme Using Magnetic Resonance Imaging Data Pre- and Post- Radiation Therapy, Journal of Research in Medical Sciences (2022)
49. Monte Carlo and Experimental Characterization of the First Amirs 103Pd Brachytherapy Source, Applied Radiation and Isotopes (2008)
50. Comparison of the Cochlea Dose in Head and Neck Cancer Patients Treated With 3-Dimensional Conformal Radiotherapy and Helical Tomotherapy; [مقایسه ی دوز حلسون گوش در بیماران مبتلا به سرطان سر و گردن تحت درمان با رادیوتراپی سه بعدی انطباقی و توموتراپی حلسونی], Journal of Isfahan Medical School (2023)