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Radiobiological Comparison of 3D Conformal and Intensity Modulated Radiation Therapy in the Treatment of Left-Sided Breast Cancer Publisher



Shanei A1 ; Amouheidari A2 ; Abedi I1 ; Kazemzadeh A3 ; Jaafari A4
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Authors Affiliations
  1. 1. Faculty Member of Medical Physics Department, Isfahan University of Medical Sciences, Isfahan, Iran
  2. 2. Radiation Oncologist, Isfahan Milad Hospital, Isfahan, Iran
  3. 3. Medical Physics, Kashan University of Medical Sciences, Kashan, Iran
  4. 4. Medical Physics, Isfahan University of Medical Sciences, Isfahan, Iran

Source: International Journal of Radiation Research Published:2020


Abstract

Background: The current study aimed to compare the tumor control probability (TCP) and normal tssue complicaton probability (NTCP) of three-dimensional conformal radiaton therapy (3D-CRT) and intensity-modulated radiaton therapy (IMRT) for left-sided breast cancer using radiobiological models. Methods: This study was conducted on 30 patents with left-sided breast cancer, who were planned for 3D-CRT and 6-9 fields IMRT treatments using the PROWESS treatment planning system. The planning target volume (PTV) dose of 50 Gy was administered for the 3D-CRT and IMRT plans, respectvely. The Niemierko's equivalent uniform dose (EUD) model was utlized for the estmaton of tumor control probability (TCP) and normal tssue complicaton probability (NTCP). Results: According to the results, the mean TCP values for 3D-CRT, 6-fields IMRT, and 9-fields IMRT plans were 99.07 ±0.07, 99.24 ±0.05 and 99.28 ±0.04, respectvely, showing no statstcally significant difference. The NTCPs of the lung and heart were considerably lower in the IMRT plans, compared to those in the 3D-CRT plans. Conclusions: From the radiobiological point of view, our results indicated that 3D-CRT produces a lower NTCP for ipsilateral lung. In contrast, for TCP calculatons, there was a higher gain with IMRT plans compared to 3D-CRT plans. © 2020 Novin Medical Radiation Institute. All rights reserved.
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