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A Comparative Planning Study on the Treatment of Gastric Cancer Patients With Tomotherapy, Coplanar and Non-Coplanar Three-Dimensional Conformal Radiotherapy (3D-Crt) Publisher



Kazemzadeh A1 ; Mahani L2 ; Kianinia M2 ; Shanei A1
Authors
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Authors Affiliations
  1. 1. Department of Medical Physics, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran
  2. 2. Department of Radio-Oncology, Seyed-Al-Shohada Hospital, Isfahan University of Medical Sciences, Isfahan, Iran

Source: International Journal of Radiation Research Published:2024


Abstract

Background: The main purpose of this study is to investigate different methods of radiotherapy (RT) using coplanar three-dimensional conformal RT (3D-CRT (cp)), non-coplanar 3D-CRT RT (3D-CRT (ncp)) and helical tomotherapy (HT) techniques to find the optimal method to treat gastric cancer patients. Materials and Methods: Twenty patients with gastric cancer were retrospectively enrolled. Three different treatment plans including HT, 3D-CRT (cp) and 3D-CRT (ncp) were generated and optimized for each patient. All plans were then evaluated with respect to dosimetric parameters exported from dose-volume histogram curves of target and organ-at-risk (OAR). SPSS software was used for statistical analysis. Results: The conformity index in the target was similar for all plans (p > 0.05), but HT showed significantly better homogeneity compared to the two 3D-CRT methods (p-value < 0.05). Compared to the 3D-CRT (cp) and 3D-CRT (ncp) plans, the HT plans significantly reduced the mean dose, V13 and V20 values of the kidneys (p-Value < 0.05); V5 values of both kidneys were lower in the 3D-CRT (ncp) plan compared to 3D-CRT (cp) and HT. The difference was statistically significant. Moreover, the results proved that the 3D-CRT (ncp) could better preserve kidneys rather than 3D-CRT (cp). Dmean of the liver for HT plans (20.03) was significantly higher than those for both coplanar and non-coplanar 3D-CRT plans (17.86 and 17.7, respectively). Conclusion: Generally, HT plans appear to be the best, but in the case of selecting an optimum method, it is necessary to pay attention to the location of tumors compared to OARs. © 2024 Novin Medical Radiation Institute. All rights reserved.
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