Isfahan University of Medical Sciences

Science Communicator Platform

Stay connected! Follow us on X network (Twitter):
Share this content! On (X network) By
Formulation and Characterization of Doxorubicin Nanovesicles Publisher



Honary S1 ; Ebrahimi P2 ; Tabbakhian M3 ; Zahir F4
Authors
Show Affiliations
Authors Affiliations
  1. 1. School of Pharmacy, Mazandaran University of Medical Sciences, Sari 48175/86l, 18th km of Khazar Rd., Iran
  2. 2. Higher Education Center, Gonbad, P.O. Box 163, Iran
  3. 3. School of Pharmacy, Esfahan University of Medical Sciences, Esfahan, Iran
  4. 4. School of Pharmacy, Mazandaran University of Medical Sciences, Sari, Iran

Source: Journal of Vacuum Science and Technology B:Nanotechnology and Microelectronics Published:2009


Abstract

Ascorbyl palmitate formed vesicles in combination with cholesterol and a negatively charged lipid (dicetyl phosphate). Niosomes were prepared by the film hydration method, followed by sonication, in which aqueous doxorubicin solution (in phosphate buffer saline pH=7.4) was encapsulated in aqueous regions of lipid layers. Vesicle's formation was confirmed by either scanning electron microscopy images or observation of unsonicated vesicles by light microscope. The percent efficiencies of doxorubicin encapsulation of the different formulations were determined by fluorescence spectrophotometry. Cholestrol content in niosomes did not exhibit any relation to vesicle size, zeta potential, percent entrapment, or release rate. Differential scanning calorimetric data of pure lipids, vesicle dispersion, and mixture of lipids confirmed the formation of niosomes. © 2009 American Vacuum Society.
Related Docs
View other Related Docs
1. Niosomes of Ascorbic Acid and Α-Tocopherol in the Cerebral Ischemia-Reperfusion Model in Male Rats, BioMed Research International (2014)
2. Release Studies on Ciprofloxacin Loaded Non-Ionic Surfactant Vesicles, Avicenna Journal of Medical Biotechnology (2015)
3. In Vitro Study of Polyoxyethylene Alkyl Ether Niosomes for Delivery of Insulin, International Journal of Pharmaceutics (2007)
4. Biotin-Encoded Pullulan-Retinoic Acid Engineered Nanomicelles: Preparation, Optimization and in Vitro Cytotoxicity Assessment in Mcf-7 Cells, Indian Journal of Pharmaceutical Sciences (2016)
5. Physicochemical, Pharmacodynamic and Pharmacokinetic Characterization of Soluplus Stabilized Nanosuspension of Tacrolimus, Current Drug Delivery (2017)
6. Development and Optimization of Solid Lipid Nanoparticles of Amikacin by Central Composite Design, Journal of Liposome Research (2010)
7. Bixin-Loaded Colloidal Nanodelivery Systems, Techniques and Applications, Food Chemistry (2023)
8. Pharmaceutical Evaluation of Atorvastatin-Loaded Nanostructured Lipid Carriers Incorporated Into the Gelatin/Hyaluronic Acid/Polycaprolactone Scaffold for the Skin Tissue Engineering, Journal of Biomaterials Applications (2021)
Experts (# of related papers)
View all Related Experts
Jaleh Varshosaz (29)
Somayeh Taymouri (5)
Other Related Docs
9. Hyaluronate Targeted Solid Lipid Nanoparticles of Etoposide: Optimization and in Vitro Characterization, Journal of Nanomaterials (2014)
10. Edta and Α-Tocopherol Improve the Chemical Stability of Astaxanthin Loaded Into Nanostructured Lipid Carriers, European Journal of Lipid Science and Technology (2014)
11. Development and in Vitro/In Vivo Evaluation of Hpmc/Chitosan Gel Containing Simvastatin Loaded Self-Assembled Nanomicelles As a Potent Wound Healing Agent, Drug Development and Industrial Pharmacy (2018)
12. Design and Characterization of Astaxanthin-Loaded Nanostructured Lipid Carriers, Innovative Food Science and Emerging Technologies (2014)
13. Self-Assembly Micelles With Lipid Core of Cholesterol for Docetaxel Delivery to B16f10 Melanoma and Hepg2 Cells, Journal of Liposome Research (2015)
14. Double Flow Focusing Microfluidic-Assisted Based Preparation of Methotrexate–Loaded Liposomal Nanoparticles: Encapsulation Efficacy, Drug Release and Stability, Colloids and Surfaces A: Physicochemical and Engineering Aspects (2021)
15. Stability of Astaxanthin-Loaded Nanostructured Lipid Carriers As Affected by Ph, Ionic Strength, Heat Treatment, Simulated Gastric Juice and Freeze–Thawing, Journal of Food Science and Technology (2017)
16. Novel Worm-Like Amphiphilic Micelles of Folate-Targeted Cyclodextrin/Retinoic Acid for Delivery of Doxorubicin in Kg-1 Cells, Colloid and Polymer Science (2014)
17. Enhancement of Oral Bioavailability of Pentoxifylline by Solid Lipid Nanoparticles, Journal of Liposome Research (2010)
18. Formulation, Optimization and Characterization of Gemfibrozil Nanocrystals Prepared by Wet Milling Technique, Asian Journal of Pharmaceutics (2015)
19. Β-Sitosterol Loaded Nanostructured Lipid Carrier: Physical and Oxidative Stability, in Vitro Simulated Digestion and Hypocholesterolemic Activity, Pharmaceutics (2020)
20. Sucrose Stearate Based Niosomes As an Alternative to Ordinary Vehicles for Efficient Curcumin Delivery, Journal of Food Measurement and Characterization (2022)
21. Nanostructured Lipid Carriers (Nlc): A Potential Delivery System for Bioactive Food Molecules, Innovative Food Science and Emerging Technologies (2013)
22. Development of Liposomes Loaded With Anti-Leishmanial Drugs for the Treatment of Cutaneous Leishmaniasis, Journal of Liposome Research (2013)
23. Development and Physical Characterization of Sorbitan Monoester Niosomes for Insulin Oral Delivery, Drug Delivery: Journal of Delivery and Targeting of Therapeutic Agents (2003)
24. Targeting Etoposide to Acute Myelogenous Leukaemia Cells Using Nanostructured Lipid Carriers Coated With Transferrin, Nanotechnology (2012)
25. Sorbitan Monopalmitate-Based Proniosomes for Transdermal Delivery of Chlorpheniramine Maleate, Drug Delivery: Journal of Delivery and Targeting of Therapeutic Agents (2005)
26. Targeted Delivery of Liposomal Ribociclib to Slc7a5 Transporters in Breast Cancer Cells, Investigational New Drugs (2024)
27. Plant Protein-Based Nanoparticles and Their Biomedical Applications, Nanomaterials and Plant Potential (2019)
28. Preparation, Characterization, and in Vitro Evaluation of Bleomycin-Containing Nanoliposomes, Chemical Biology and Drug Design (2017)
29. Formulation of Ldl Targeted Nanostructured Lipid Carriers Loaded With Paclitaxel: A Detailed Study of Preparation, Freeze Drying Condition, and in Vitro Cytotoxicity, Journal of Nanomaterials (2012)
30. Formulation and Characterization of Taxifolin-Loaded Lipid Nanovesicles (Liposomes, Niosomes, and Transfersomes) for Beverage Fortification, European Journal of Lipid Science and Technology (2020)
31. Screening the Most Effective Variables on Physical Properties of Folate-Targeted Dextran/Retinoic Acid Micelles by Taguchi Design, Journal of Nanomaterials (2012)
32. Formulation and Characterization of Novel Nanostructured Lipid Carriers Made From Beeswax, Propolis Wax and Pomegranate Seed Oil, Food Chemistry (2018)
33. Hesperetin-Loaded Solid Lipid Nanoparticles and Nanostructure Lipid Carriers for Food Fortification: Preparation, Characterization, and Modeling, Food and Bioprocess Technology (2013)
34. Niosome As a Drug Carrier for Topical Delivery of N-Acetyl Glucosamine, Research in Pharmaceutical Sciences (2010)
35. Thermosensitive Hydrogel Containing Sertaconazole Loaded Nanostructured Lipid Carriers for Potential Treatment of Fungal Keratitis, Pharmaceutical Development and Technology (2019)
36. The Recent Progresses on the Improved Therapy of Melanoma by Novel Drug Delivery Systems, Current Drug Targets (2014)
37. Propolis Wax Nanostructured Lipid Carrier for Delivery of Β Sitosterol: Effect of Formulation Variables on Physicochemical Properties, Food Chemistry (2018)