Isfahan University of Medical Sciences

Science Communicator Platform

Stay connected! Follow us on X network (Twitter):
Share By
Propolis Wax Nanostructured Lipid Carrier for Delivery of Β Sitosterol: Effect of Formulation Variables on Physicochemical Properties Publisher



Soleimanian Y1 ; Goli SAH1 ; Varshosaz J2 ; Maestrelli F3
Authors

Source: Food Chemistry Published:2018


Abstract

Preparation and characterization of novel functional nanostructured lipid carriers containing β sitosterol has been studied. The nanostructured lipid carrires (NLCs) were formulated with propolis wax (PW) alone or in mixture (1:1 w/w) with glyceryl behenate (GB), and pomegranate seed oil (PSO) and produced by a hot melt emulsification method. Response surface methodology was used to optimize formulations with respect to β sitosterol concentration, liquid lipid content and solid lipid composition. The NLCs formulated with less oil and higher drug content showed higher size and lower encapsulation efficiency. Solid state analysis exhibited lower crystallinity of optimal formulations compared to raw lipids and a drug amorphization into the NLC matrix. The compatibility between drug and encapsulating materials was confirmed by Fourier transform infrared spectroscopy. Transmission electron microscopy showed spherical particles ranged around 100 nm confirming the applicability of such formulations for the production of functional foods. © 2018 Elsevier Ltd
Related Docs
View other Related Docs
1. Formulation and Characterization of Novel Nanostructured Lipid Carriers Made From Beeswax, Propolis Wax and Pomegranate Seed Oil, Food Chemistry (2018)
2. Β-Sitosterol Loaded Nanostructured Lipid Carrier: Physical and Oxidative Stability, in Vitro Simulated Digestion and Hypocholesterolemic Activity, Pharmaceutics (2020)
3. Nanostructured Lipid Carriers (Nlc): A Potential Delivery System for Bioactive Food Molecules, Innovative Food Science and Emerging Technologies (2013)
Experts (# of related papers)
View all Related Experts
Jaleh Varshosaz (15)
Mahboubeh Rezazadeh (2)
Other Related Docs
4. Design and Characterization of Astaxanthin-Loaded Nanostructured Lipid Carriers, Innovative Food Science and Emerging Technologies (2014)
5. Β-Sitosterol Lipid Nano Carrier Based on Propolis Wax and Pomegranate Seed Oil: Effect of Thermal Processing, Ph, and Ionic Strength on Stability and Structure, European Journal of Lipid Science and Technology (2019)
6. Stability of Astaxanthin-Loaded Nanostructured Lipid Carriers As Affected by Ph, Ionic Strength, Heat Treatment, Simulated Gastric Juice and Freeze–Thawing, Journal of Food Science and Technology (2017)
7. Effects of Thermal Processing and Ph on the Physicochemical Properties, Stability, and Structure of Taxifolin-Loaded Nanostructured Lipid Carriers, Applied Food Research (2024)
8. Formulation and Optimization of Solid Lipid Nanoparticle Formulation for Pulmonary Delivery of Budesonide Using Taguchi and Box-Behnken Design, Research in Pharmaceutical Sciences (2015)
9. Formulation of Ldl Targeted Nanostructured Lipid Carriers Loaded With Paclitaxel: A Detailed Study of Preparation, Freeze Drying Condition, and in Vitro Cytotoxicity, Journal of Nanomaterials (2012)
10. Fabrication of Edible Solid Lipid Nanoparticle From Beeswax/Propolis Wax by Spontaneous Emulsification: Optimization, Characterization and Stability, Food Chemistry (2022)
11. Cinnamaldehyde Encapsulation Within New Natural Wax-Based Nanoparticles; Formation, Optimization and Characterization, Journal of Dispersion Science and Technology (2023)
12. Edta and Α-Tocopherol Improve the Chemical Stability of Astaxanthin Loaded Into Nanostructured Lipid Carriers, European Journal of Lipid Science and Technology (2014)
13. Hyaluronate Targeted Solid Lipid Nanoparticles of Etoposide: Optimization and in Vitro Characterization, Journal of Nanomaterials (2014)
14. Edible Wax-Based Nanoparticles As Novel Stabilizers for Oil-In-Water Pickering Emulsion, Food and Bioprocess Technology (2023)
15. Release of Bioactive Compounds From Delivery Systems by Stimuli-Responsive Approaches; Triggering Factors, Mechanisms, and Applications, Advances in Colloid and Interface Science (2022)
16. Preparation and Characterization of Eudragit L 100-55/Chitosan Enteric Nanoparticles Containing Omeprazole Using General Factorial Design: In Vitro/In Vivo Study, Research in Pharmaceutical Sciences (2021)
17. Lipid-Based Nanodelivery Systems of Curcumin: Recent Advances, Approaches, and Applications, Food Chemistry (2025)
18. Lycopene Nanodelivery Systems; Recent Advances, Trends in Food Science and Technology (2022)
19. Synthesis of Octadecylamine-Retinoic Acid Conjugate for Enhanced Cytotoxic Effects of 5-Fu Using Ldl Targeted Nanostructured Lipid Carriers, European Journal of Medicinal Chemistry (2012)
20. Thermosensitive Hydrogel Containing Sertaconazole Loaded Nanostructured Lipid Carriers for Potential Treatment of Fungal Keratitis, Pharmaceutical Development and Technology (2019)