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Formulation and Characterization of Novel Nanostructured Lipid Carriers Made From Beeswax, Propolis Wax and Pomegranate Seed Oil Publisher Pubmed



Soleimanian Y1 ; Goli SAH1 ; Varshosaz J2 ; Sahafi SM1
Authors
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Authors Affiliations
  1. 1. Department of Food Science and Technology, College of Agriculture, Isfahan University of Technology, Isfahan, 84156-83111, Iran
  2. 2. Department of Pharmaceutics, Faculty of Pharmacy and Novel Drug Delivery Systems Research Center, Isfahan University of Medical Sciences, Isfahan, 81746-73461, Iran

Source: Food Chemistry Published:2018


Abstract

The objective of this study was to develop functional nanostructured lipid carriers (NLCs) using beeswax (BW), propolis wax (PW) and pomegranate seed oil (PSO). NLCs were prepared by a melt emulsification-ultra sonication technique. The influences of solid lipid composition, surfactant blend concentration (2, 4, and 6% of formulation) and PSO content (10, 30 and 50% of total lipid phase) were investigated. Statistical evaluations revealed that the formulation variables had significant effects on physical properties of NLC. The developed nanocarriers presented particle sizes ranging from 71 to 366 nm, leading to excellent physical stability. The optimum formulations with minimum particle size and high zeta potential value were PW and BW + glycerol behenate samples, containing 10% oil and 6% surfactant. DSC and XRD studies indicated that the addition of oil to the lipid phase could disturb the crystalline order and form lattice defects. TEM observations exhibited spherical morphology of the NLCs. © 2017 Elsevier Ltd
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