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Global Burden of Peripheral Artery Disease and Its Risk Factors, 1990–2019: A Systematic Analysis for the Global Burden of Disease Study 2019 Publisher Pubmed



Kim MS1 ; Hwang J2 ; Yon DK3 ; Lee SW4 ; Jung SY5 ; Park S6 ; Johnson CO7 ; Stark BA7 ; Razo C7 ; Abbasian M10, 15 ; Abbastabar H19 ; Abhari AP29 ; Aboyans V31, 32 ; Adane DEA33 Show All Authors
Authors
  1. Kim MS1
  2. Hwang J2
  3. Yon DK3
  4. Lee SW4
  5. Jung SY5
  6. Park S6
  7. Johnson CO7
  8. Stark BA7
  9. Razo C7
  10. Abbasian M10, 15
  11. Abbastabar H19
  12. Abhari AP29
  13. Aboyans V31, 32
  14. Adane DEA33
  15. Adebayo OM34
  16. Alahdab F37
  17. Almustanyir S39, 40
  18. Aly H41
  19. Ameyaw EK43
  20. Anderson JA7
  21. Andrei CL44
  22. Aryan Z11, 20
  23. Aujayeb A46
  24. Bagherieh S29
  25. Baltatu OC47, 48
  26. Banach M49, 50
  27. Bayileyegn NS51
  28. Bearne LM52, 53
  29. Behnoush AH20, 21
  30. Bensenor IM54
  31. Bhaskar S55, 56
  32. Bhat AN57
  33. Bhat V58
  34. Bikbov B59
  35. Bintoro BS60, 61
  36. Burkart K7, 8
  37. Camera LA62, 63
  38. Catapano AL64, 65
  39. Chandrasekar EK66
  40. Charan J68
  41. Chattu VK69, 70
  42. Chi G12
  43. Chukwu IS71
  44. Chung SC72, 73
  45. Cirillo M74
  46. Coberly K7
  47. Costa VM75
  48. Dadras O76, 77
  49. Dai X7, 8
  50. Do TC80
  51. Doshi R81
  52. Ekholuenetale M82, 83
  53. Elgendy IY12, 86
  54. Elhadi M87
  55. Fagbamigbe AF82, 88
  56. Feizkhah A89
  57. Fekadu G90, 91
  58. Gill PS92
  59. Goldust M93
  60. Golechha M94
  61. Guan SY95
  62. Gupta VK96
  63. Hadei M22
  64. Hadi NR97
  65. Hammoud A98
  66. Hankey GJ99, 100
  67. Harlianto NI101, 102
  68. Hasaballah AI103
  69. Hassan S78, 79
  70. Hassen MB7, 104
  71. Heidari G105
  72. Hostiuc M45
  73. Ilesanmi OS35, 84
  74. Iwagami M106, 107
  75. Jokar M108, 110
  76. Jonas JB111, 112
  77. Joshua CE113
  78. Jozwiak JJ114
  79. Kazemian S23, 24
  80. Keykhaei M20, 25
  81. Khalaji A21, 116
  82. Khan MAB117, 118
  83. Khateri S119
  84. Kibret BG120
  85. Korzh O121
  86. Koulmane Laxminarayana SL122
  87. Krishan K123
  88. Kumar A124, 125
  89. Kumar M126, 127
  90. Kuttikkattu A128
  91. Laksono T129, 130
  92. Larijani B26
  93. Le TTT132
  94. Lim SS7, 8
  95. Liu X42, 133
  96. Lorkowski S134, 135
  97. Magdy Abd El Razek H136
  98. Malhotra K139
  99. Manla Y140
  100. Maugeri A141
  101. Mentis AFA142
  102. Mestrovic T7, 143
  103. Micheletti Gomide Nogueira De Sa AC144
  104. Mirica A145
  105. Mirrakhimov EM146, 147
  106. Misganaw A8, 104
  107. Mishra M148
  108. Mohammad Y149
  109. Mokdad AH7, 8
  110. Moni MA150
  111. Montasir AA151, 152
  112. Moradi Y153
  113. Moraga P154
  114. Morovatdar N155
  115. Mousaviaghdas SA158
  116. Murray CJL7, 8
  117. Naghavi M7, 8
  118. Nair TS160
  119. Nassereldine H7
  120. Natto ZS13, 161
  121. Nguyen DH86, 162
  122. Nguyen HQ163
  123. Nguyen VT131
  124. Noubiap JJ164
  125. Oancea B165
  126. Oliveira GMM166
  127. Owolabi MO36, 85
  128. Padronmonedero A167
  129. Perico N168
  130. Petcu IR145
  131. Radfar A169
  132. Rafferty Q7
  133. Rahman M170
  134. Rahman MA171, 172
  135. Ram P173
  136. Rashedi S27, 115
  137. Rashid AM174
  138. Rawaf S175, 176
  139. Remuzzi G168
  140. Renzaho AMN177, 178
  141. Rezaee M16, 24
  142. Roever L179
  143. Saad AMA180
  144. Saadatagah S38
  145. Sadeghi M30
  146. Sahebkar A156, 157
  147. Saleh MA137, 181
  148. Samy AM182, 183
  149. Santricmilicevic MM184, 185
  150. Sepanlou SG28, 186
  151. Seylani A187
  152. Sharfaei S14, 188
  153. Shorofi SA189, 190
  154. Singh JA191, 192
  155. Singh P193
  156. Spartalis M194
  157. Sundstrom J195, 196
  158. Tan KK197
  159. Teramoto M198
  160. Tharwat S138
  161. Tyrovolas S199, 200
  162. Valadan Tahbaz S109, 201
  163. Van Den Eynde J202
  164. Vart P203
  165. Wang C204, 205
  166. Wang F206
  167. Westerman R207
  168. Xia J208
  169. Xu S67, 209
  170. Yada DY7
  171. Yamagishi K106, 210
  172. Yonemoto N211, 212
  173. Zahir M17
  174. Zangiabadian M18
  175. Zarrintan A159
  176. Zastrozhin MS213, 214
  177. Zastrozhina A215
  178. Zoladl M216
  179. Hay SI7, 8
  180. Shin JI5
  181. Roth GA7, 8, 9

Source: The Lancet Global Health Published:2023


Abstract

Background: Peripheral artery disease is a growing public health problem. We aimed to estimate the global disease burden of peripheral artery disease, its risk factors, and temporospatial trends to inform policy and public measures. Methods: Data on peripheral artery disease were modelled using the Global Burden of Disease, Injuries, and Risk Factors Study (GBD) 2019 database. Prevalence, disability-adjusted life years (DALYs), and mortality estimates of peripheral artery disease were extracted from GBD 2019. Total DALYs and age-standardised DALY rate of peripheral artery disease attributed to modifiable risk factors were also assessed. Findings: In 2019, the number of people aged 40 years and older with peripheral artery disease was 113 million (95% uncertainty interval [UI] 99·2–128·4), with a global prevalence of 1·52% (95% UI 1·33–1·72), of which 42·6% was in countries with low to middle Socio-demographic Index (SDI). The global prevalence of peripheral artery disease was higher in older people, (14·91% [12·41–17·87] in those aged 80–84 years), and was generally higher in females than in males. Globally, the total number of DALYs attributable to modifiable risk factors in 2019 accounted for 69·4% (64·2–74·3) of total peripheral artery disease DALYs. The prevalence of peripheral artery disease was highest in countries with high SDI and lowest in countries with low SDI, whereas DALY and mortality rates showed U-shaped curves, with the highest burden in the high and low SDI quintiles. Interpretation: The total number of people with peripheral artery disease has increased globally from 1990 to 2019. Despite the lower prevalence of peripheral artery disease in males and low-income countries, these groups showed similar DALY rates to females and higher-income countries, highlighting disproportionate burden in these groups. Modifiable risk factors were responsible for around 70% of the global peripheral artery disease burden. Public measures could mitigate the burden of peripheral artery disease by modifying risk factors. Funding: Bill & Melinda Gates Foundation. © 2023 The Author(s). Published by Elsevier Ltd. This is an Open Access article under the CC BY 4.0 license
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