Isfahan University of Medical Sciences

Science Communicator Platform

Stay connected! Follow us on X network (Twitter):
Share this content! On (X network) By
The a Ssociation of 25-Hydroxy Vitamin D Level in Mothers With Term and Preterm Delivery and Their Neonates Publisher



Shahraki AD1 ; Hasanabadi MS1 ; Dehkordi AF2
Authors
Show Affiliations
Authors Affiliations
  1. 1. Department of Obstetrics and Genecology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran
  2. 2. Department of Obstetrics and Gynecology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran

Source: Journal of Research in Medical Sciences Published:2020


Abstract

Background: Risk factors for maternal Vitamin D deficiency and preterm birth are convergence, but the distribution of 25-hydroxyvitamin D (25(OH) Vitamin D) levels among preterm infants is not known. We aimed to assess the association of 25(OH) Vitamin D levels in mothers with term and preterm delivery with their neonates. Materials and Methods: This case-control study was conducted on 62 mothers with spontaneous preterm delivery and their neonates as the case group and 124 mothers with term delivery and their neonates as the control group. From mothers and neonate's umbilical cord at birth, 10 cc blood was taken and immediately sent to the laboratory for measuring Vitamin D levels. Pearson correlation, independent samples t-test, and kappa concordance coefficient were used for data analysis. Results: In the term group, 102 cases (82.3%) had Vitamin D deficiency/insufficiency and 22 cases (17.7%) had normal Vitamin D level while in the preterm group, 56 cases (90.3%) had Vitamin D deficiency/insufficiency, and 6 cases (9.7%) had normal Vitamin D level (P > 0.05). The correlation between maternal and neonatal 25(OH) Vitamin D levels in the term and preterm group was statistically significant (term group: r = 0.874, P < 0.001 and preterm group: r = 0.733, P < 0.001).Conclusion: Our study did not show a significant difference between two groups in terms of Vitamin D status both in mothers and neonates while the significant association was found between Vitamin D levels of mothers and neonates in both groups. These findings confirmed the previous studies' findings that Vitamin D levels in neonates could be predicted from their mothers. As a result, successful Vitamin D and calcium supplementation for improving 25(OH) Vitamin D levels in the maternal and neonatal populations for protecting the harmful effects of Vitamin D insufficiency/deficiency are recommended. © 2020 Wolters Kluwer Medknow Publications. All rights reserved.
Related Docs
View other Related Docs
1. Maternal Vitamin D Status and Risk of Pre-Eclampsia: A Systematic Review and Meta-Analysis, Journal of Clinical Endocrinology and Metabolism (2013)
2. Vitamin D Deficiency Among Pregnant Women and Their Newborns in Isfahan, Iran, Experimental and Clinical Endocrinology and Diabetes (2008)
3. The Effects of Serum and Follicular Fluid Vitamin D Levels on Assisted Reproductive Techniques: A Prospective Cohort Study, International Journal of Fertility and Sterility (2021)
4. Comparison of Daily Dose of 400 and 600 Units of Vitamin D in the Prevention of Osteopenia of Prematurity in Infants With a Gestational Age of Less Than and Equal to 32 Weeks, International Journal of Preventive Medicine (2024)
5. Is Vitamin D Deficiency Prevalent in Healthy 6-Yearold Children in Isfahan City?, Journal of Isfahan Medical School (2007)
6. Valuation of Vitamin D Level at the End of First Trimester and Its Relation With Anemia, Bacterial Vaginosis, and Toothache in Pregnant Mothers, Journal of Isfahan Medical School (2015)
7. Favorable Effects of Vitamin D Supplementation on Pregnancy Outcomes in Gestational Diabetes: A Double Blind Randomized Controlled Clinical Trial, Hormone and Metabolic Research (2014)
8. Relationship Between 25-Hydroxyvitamin D3 Levels With Pain Intensity and Duration of Labor Stages in Primiparous Women, Iranian Journal of Nursing and Midwifery Research (2024)
Experts (# of related papers)
View all Related Experts
Roya Kelishadi (33)
Parvane Saneei (14)
Other Related Docs
9. Determinants of Hypovitaminosis D in Pregnant Women and Their Newborns in a Sunny Region, International Journal of Endocrinology (2013)
10. Calcium-Vitamin D Co-Supplementation Affects Metabolic Profiles, But Not Pregnancy Outcomes, in Healthy Pregnant Women, International Journal of Preventive Medicine (2016)
11. Effects of Vitamin D Supplementation on Glucose Metabolism, Lipid Concentrations, Inflammation, and Oxidative Stress in Gestational Diabetes: A Double-Blind Randomized Controlled Clinical Trial1-3, American Journal of Clinical Nutrition (2013)
12. The Association Between Vitamin D and Premenstrual Syndrome: A Systematic Review and Meta-Analysis of Current Literature, Journal of the American College of Nutrition (2019)
13. The Effect of Multi Mineral‑Vitamin D Supplementation on Pregnancy Outcomes in Pregnant Women at Risk for Pre‑Eclampsia, International Journal of Preventive Medicine (2015)
14. Association of Vitamin D Status and Cardio-Metabolic Risk Factors in Children and Adolescents: The Caspian-V Study, BMC Nutrition (2021)
15. Comparison of Sun Exposure Versus Vitamin D Supplementation for Pregnant Women With Vitamin D Deficiency, Journal of Maternal-Fetal and Neonatal Medicine (2019)
16. Comparison of 25- Hydroxy Vitamin D Levels in Premature Infants With and Without Respiratory Distress, Iranian Journal of Neonatology (2020)
17. Maternal Vitamin D Status and Risk of Gestational Diabetes Mellitus: A Systematic Review and Meta-Analysis of Prospective Cohort Studies, Clinical Nutrition (2021)
18. The Prevalence of Vitamin D Deficiency in Iran: A Literature Review, Current Nutrition and Food Science (2020)
19. Vitamin D and Biomarkers of Inflammation and Oxidative Stress Among Pregnant Women: A Systematic Review of Observational Studies, BMC Immunology (2023)
20. Serum Vitamin D Levels and Covid-19 During Pregnancy: A Systematic Review and Meta-Analysis, Clinical Nutrition ESPEN (2022)
21. Calcium Plus Vitamin D Supplementation Affects Pregnancy Outcomes in Gestational Diabetes: Randomized, Double-Blind, Placebo-Controlled Trial, Public Health Nutrition (2016)
22. Effect of Vitamin D Supplementation on Serum 25-Hydroxyvitamin D and Homeostatic Model of Insulin Resistance Levels in Healthy Pregnancy: A Systematic Review and Meta-Analysis, Iranian Journal of Medical Sciences (2023)
23. Vitamin D Supplementation Affects Serum High-Sensitivity C-Reactive Protein, Insulin Resistance, and Biomarkers of Oxidative Stress in Pregnant Women, Journal of Nutrition (2013)
24. The Effect of Vitamin D Supplementation on Oxidative Stress and Inflammatory Biomarkers in Pregnant Women: A Systematic Review and Meta-Analysis of Clinical Trials, BMC Pregnancy and Childbirth (2022)
25. Effect of Vitamin D Supplementation on Symptoms Severity in Vitamin D Insufficient Women With Premenstrual Syndrome: A Randomized Controlled Trial, Clinical Nutrition ESPEN (2024)
26. Prevalence and Trends of Vitamin D Deficiency Among Iranian Adults: A Longitudinal Study From 2001–2013, Journal of Nutritional Science and Vitaminology (2017)
27. Evaluation of Vitamin D Level in the Blood Serum of Depressed Women After Childbirth in the City of Isfahan, Iran, Iranian Journal of Obstetrics, Gynecology and Infertility (2018)
28. Circulating Vitamin D and the Risk of Gestational Diabetes: A Systematic Review and Dose-Response Meta-Analysis, Endocrine (2020)
29. Effects of Calcium-Vitamin D Co-Supplementation on Glycaemic Control, Inflammation and Oxidative Stress in Gestational Diabetes: A Randomised Placebo-Controlled Trial, Diabetologia (2014)
30. The Effects of Vitamin D Plus Calcium Supplementation on Metabolic Profiles, Biomarkers of Inflammation, Oxidative Stress and Pregnancy Outcomes in Pregnant Women at Risk for Pre-Eclampsia, Journal of human nutrition and dietetics : the official journal of the British Dietetic Association (2016)
31. The Relationship Between Maternal Vitamin D Levels and Osteopenia Development in Preterm Infants: A Cross-Sectional Study, International Journal of Reproductive BioMedicine (2024)
32. Mean Serum Levels of Vitamin D in Elderly Women, Isfahan, Iran, Journal of Isfahan Medical School (2012)
33. Effect of Vitamin E in Prevention of Intraventricular Hemorrhage in Preterm Neonates, International Journal of Preventive Medicine (2018)
34. Association of Serum 25-Hydroxyvitamin D Concentration With Anthropometric Measures in Children and Adolescents: The Caspian-V Study, Eating and Weight Disorders (2021)
35. Ction With Mortality in Pediatric Intensive Care Unit, Journal of Isfahan Medical School (2018)
36. Prevalence of Vitamin D Deficiency Among Adult Population of Isfahan City, Iran, Journal of Health, Population and Nutrition (2011)
37. Serum Vitamin D Levels in Relation to Metabolic Syndrome: A Systematic Review and Dose–Response Meta-Analysis of Epidemiologic Studies, Obesity Reviews (2021)
38. Vitamin D Status of 6- to 7-Year-Old Children Living in Isfahan, Iran, Endokrynologia Polska (2010)
39. Comparison of Vitamin D Deficiency in Women With Polycystic Ovary Syndrome Who Referred to Infertility Clinic With Control Group, Journal of Isfahan Medical School (2016)
40. Vitamin D Supplementation for Premenstrual Syndrome-Related Inflammation and Antioxidant Markers in Students With Vitamin D Deficient: A Randomized Clinical Trial, Scientific Reports (2019)
41. Association of Vitamin D Concentrations With Subjective Health Complaints in Children and Adolescents: The Caspian-V Study, BMC Public Health (2021)
42. Percentile Values for Serum Levels of Vitamins a and D in Iranian Children and Adolescents: The Caspian-V Study, Nutrition (2021)
43. The Relationship of Serum Vitamin D and Zinc in a Nationally Representative Sample of Iranian Children and Adolescents: The Caspian-Iii Study, Medical Journal of the Islamic Republic of Iran (2016)
44. Serum Levels of Vitamin D, Retinol and Zinc in Relation to Overweight Among Toddlers: Findings From a National Study in Iran, Archives of Iranian Medicine (2019)
45. Prevalence and Determinants of Vitamin D Deficiency in Iranian Children and Adolescents: The Caspian-V Study, Journal of Diabetes and Metabolic Disorders (2021)
46. The Effects of Uric Acid, Serum Vitamin D3, and Their Interaction on Parkinson's Disease Severity, Parkinson's Disease (2015)
47. Circulating Serum Vitamin D Levels in Relation to Metabolic Syndrome in Children: A Systematic Review and Dose–Response Meta-Analysis of Epidemiologic Studies, Obesity Reviews (2021)
48. The Effect of Vitamin D Supplementation on Body Composition in Nursing Mothers With Overweight or Obesity: A Randomized Double-Blind Placebo-Controlled Clinical Trial, BMC Nutrition (2023)
49. The Assessment of Neonatal Anthropometric Indices Association With Umbilical Cord Blood Zinc and Magnesium Levels, Advanced Biomedical Research (2023)
50. The Association Between Serum Vitamin D Levels and Abnormal Lipid Profile in Pediatrics: A Grade-Assessed Systematic Review and Dose–Response Meta-Analysis of Epidemiologic Studies, Nutrition Reviews (2025)