Isfahan University of Medical Sciences

Science Communicator Platform

Stay connected! Follow us on X network (Twitter):
Share this content! On (X network) By
The Relationship Between Maternal Vitamin D Levels and Osteopenia Development in Preterm Infants: A Cross-Sectional Study Publisher



Tabatabaei RS1, 2 ; Mirjalili SR2 ; Ashrafi A3 ; Shamsi F4
Authors
Show Affiliations
Authors Affiliations
  1. 1. Department of Obstetrics and Gynecology, School of Medicine, Shahid Sadoughi University of Medical Sciences, Yazd, Iran
  2. 2. Mother and Newborn Health Research Center, Shahid Sadoughi University of Medical Sciences, Yazd, Iran
  3. 3. Department of Obstetrics and Gynecology, Shahid Beheshti Hospital, Esfahan University of Medical Sciences, Ardestan, Iran
  4. 4. Department of Biostatistics and Epidemiology, School of Public Health, Shahid Sadoughi University of Medical Sciences, Yazd, Iran

Source: International Journal of Reproductive BioMedicine Published:2024


Abstract

Background: Osteopenia of prematurity (OP) is characterized by reduced bone mineral content, and vitamin D deficiency may worsen OP by affecting bone metabolism. Objective: This study aimed to investigate the correlation between maternal vitamin D levels and biochemical markers related to OP. Materials and Methods: This analytical cross-sectional study, conducted at Shahid Sadoughi hospital, Yazd, Iran, from June 2022 to September 2023, included 49 pregnant women and their preterm infants. Based on the serum alkaline phosphatase and phosphorus levels of the infants at birth and 4 wk after birth, they were divided into osteopenic and non-osteopenic groups. Maternal and neonatal vitamin D and calcium levels were then compared between these groups. Results: The mean maternal vitamin D level was 24.9 ± 15.09 ng/ml, with 36% showing deficiency. 11 neonates at 4 wk exhibited osteopenia based on phosphorus and serum alkaline phosphatase levels. Those with osteopenia had significantly lower vitamin D (p = 0.032) and calcium levels compared to non-osteopenic neonates (p = 0.043), although maternal vitamin D mean was not a significant risk factor for OP (p = 0.313). Conclusion: The results suggest that maternal vitamin D levels do not have a significant association with the incidence of osteopenia in neonates, as the mean maternal vitamin D concentration was not identified as a risk factor for this condition. Therefore, it is recommended that future research should investigate alternative factors that may contribute to the development of osteopenia in preterm infants. © 2024, Research and Clinical Center for Infertitlity. All rights reserved.
Related Docs
View other Related Docs
1. Comparison of Daily Dose of 400 and 600 Units of Vitamin D in the Prevention of Osteopenia of Prematurity in Infants With a Gestational Age of Less Than and Equal to 32 Weeks, International Journal of Preventive Medicine (2024)
2. Vitamin D Deficiency Among Pregnant Women and Their Newborns in Isfahan, Iran, Experimental and Clinical Endocrinology and Diabetes (2008)
3. Valuation of Vitamin D Level at the End of First Trimester and Its Relation With Anemia, Bacterial Vaginosis, and Toothache in Pregnant Mothers, Journal of Isfahan Medical School (2015)
4. Comparison of Sun Exposure Versus Vitamin D Supplementation for Pregnant Women With Vitamin D Deficiency, Journal of Maternal-Fetal and Neonatal Medicine (2019)
5. Prevalence of Vitamin D Deficiency in Isfahani High School Students in 2004, Hormone Research (2005)
6. Correlation Between Serum Parathyroid Hormone and Markers of Bone Metabolism in Hemodialysis Patients, Journal of Isfahan Medical School (2013)
7. Calcium-Vitamin D Co-Supplementation Affects Metabolic Profiles, But Not Pregnancy Outcomes, in Healthy Pregnant Women, International Journal of Preventive Medicine (2016)
8. Antioxidant and Bone; Protect Your Future: A Brief Review, Iranian Journal of Public Health (2021)
Experts (# of related papers)
View all Related Experts
Roya Kelishadi (13)
Reza Amani (5)
Other Related Docs
9. The a Ssociation of 25-Hydroxy Vitamin D Level in Mothers With Term and Preterm Delivery and Their Neonates, Journal of Research in Medical Sciences (2020)
10. The Effect of Multi Mineral‑Vitamin D Supplementation on Pregnancy Outcomes in Pregnant Women at Risk for Pre‑Eclampsia, International Journal of Preventive Medicine (2015)
11. The Effect of Vitamin D Supplementation on Body Composition in Nursing Mothers With Overweight or Obesity: A Randomized Double-Blind Placebo-Controlled Clinical Trial, BMC Nutrition (2023)
12. Association of Vitamin D, Retinol and Zinc Deficiencies With Stunting in Toddlers: Findings From a National Study in Iran, Public Health (2020)
13. Association of Cord Blood Zinc Level and Birth Weight in a Sample of Iranian Neonates, International Journal of Preventive Medicine (2020)
14. Serum Levels of Vitamin D, Retinol and Zinc in Relation to Overweight Among Toddlers: Findings From a National Study in Iran, Archives of Iranian Medicine (2019)
15. Clinical Practices and Therapeutic Management of Mineral and Bone Disorders in Chronic Kidney Disease 4, 5 and 5D: The Oceanos Study in Iran, Nephro-Urology Monthly (2018)
16. The Relationship of Serum Vitamin D and Zinc in a Nationally Representative Sample of Iranian Children and Adolescents: The Caspian-Iii Study, Medical Journal of the Islamic Republic of Iran (2016)
17. Evaluation of the Effects of Vitamin E on Prematurity Complications in Premature Neonates, Journal of Isfahan Medical School (2017)
18. Association of Vitamin D Levels With Anthropometric and Adiposity Indicators Across All Age Groups: A Systematic Review of Epidemiologic Studies, Endocrine Connections (2024)
19. Maternal Vitamin D Status and Risk of Gestational Diabetes Mellitus: A Systematic Review and Meta-Analysis of Prospective Cohort Studies, Clinical Nutrition (2021)
20. Dietary Determinants of Pregnancy Induced Hypertension in Isfahan, Journal of Research in Medical Sciences (2008)
21. Association Between Serum Biochemical Levels, Related to Bone Metabolism and Parkinson's Disease, Journal of Research in Medical Sciences (2013)
22. Investigating the Prevalence of Osteoporosis Risk Factors in Postmenopausal Women Less Than 65 Years of Age Referring to Al-Zahra Hospital; [بررسی شیوع عوامل خطر پوکی استخوان در زنان یائسه کمتر از ۶۵ سال مراجعه کنندهبه بیمارستان الزهرا (س)], Journal of Isfahan Medical School (2024)
23. The Effect of Alendronate on Lipid Profile of Postmenopausal Women With Osteopenia and Prediabetes: A Randomized Triple-Blind Clinical Trial, Journal of Research in Medical Sciences (2021)
24. Comparison of 25- Hydroxy Vitamin D Levels in Premature Infants With and Without Respiratory Distress, Iranian Journal of Neonatology (2020)
25. Association of Vitamin D Status and Cardio-Metabolic Risk Factors in Children and Adolescents: The Caspian-V Study, BMC Nutrition (2021)
26. Serum Level of Vitamin D and Distal Radius Fractures: A Case-Control Study, Journal of Isfahan Medical School (2017)
27. Vitamin D Supplementation for Premenstrual Syndrome-Related Inflammation and Antioxidant Markers in Students With Vitamin D Deficient: A Randomized Clinical Trial, Scientific Reports (2019)
28. The Assessment of Neonatal Anthropometric Indices Association With Umbilical Cord Blood Zinc and Magnesium Levels, Advanced Biomedical Research (2023)
29. Comparison of Vitamin D Deficiency in Women With Polycystic Ovary Syndrome Who Referred to Infertility Clinic With Control Group, Journal of Isfahan Medical School (2016)
30. Active Form and Reservoir Form of Vitamin D in Children With Acute Lower Respiratory Infections and Its Association With Severity of the Infection, Archives of Pediatric Infectious Diseases (2019)
31. Postpartum Depression and Vitamin D: A Systematic Review, Critical Reviews in Food Science and Nutrition (2019)
32. Bone Mineral Density in Ambulatory Children With Epilepsy, Indian Journal of Pediatrics (2015)
33. Relation Between Biochemical Parameters and Bone Density in Postmenopausal Women With Osteoporosis, Advanced Biomedical Research (2023)
34. Alendronate Improves Fasting Plasma Glucose and Insulin Sensitivity, and Decreases Insulin Resistance in Prediabetic Osteopenic Postmenopausal Women: A Randomized Triple-Blind Clinical Trial, Journal of Diabetes Investigation (2019)
35. Vitamin D Status of 6- to 7-Year-Old Children Living in Isfahan, Iran, Endokrynologia Polska (2010)
36. The Association Between Vitamin D and Premenstrual Syndrome: A Systematic Review and Meta-Analysis of Current Literature, Journal of the American College of Nutrition (2019)
37. Calcium Plus Vitamin D Supplementation Influences Biomarkers of Inflammation and Oxidative Stress in Overweight and Vitamin D-Deficient Women With Polycystic Ovary Syndrome: A Randomized Double-Blind Placebo-Controlled Clinical Trial, Clinical Endocrinology (2015)
38. Prevalence of Vitamin D Deficiency Among Adult Population of Isfahan City, Iran, Journal of Health, Population and Nutrition (2011)
39. Effect of Supplemental Vitamin D3 on Bone Mineral Density: A Systematic Review and Meta-Analysis, Nutrition Reviews (2023)
40. Association of Serum 25-Hydroxyvitamin D Concentration With Anthropometric Measures in Children and Adolescents: The Caspian-V Study, Eating and Weight Disorders (2021)
41. Effects of Vitamin D Supplementation on Glucose Metabolism, Lipid Concentrations, Inflammation, and Oxidative Stress in Gestational Diabetes: A Double-Blind Randomized Controlled Clinical Trial1-3, American Journal of Clinical Nutrition (2013)
42. Serum Levels of 25-Hydroxy Vitamin D in Patients With Hepatitis C Compared With Control Group, Journal of Isfahan Medical School (2016)
43. Effect of Vitamin E in Prevention of Intraventricular Hemorrhage in Preterm Neonates, International Journal of Preventive Medicine (2018)
44. Association Between Biomarkers of Bone Health and Osteosarcopenia Among Iranian Older People: The Bushehr Elderly Health (Beh) Program, BMC Geriatrics (2021)
45. Multivitamin Versus Multivitamin-Mineral Supplementation and Pregnancy Outcomes: A Single-Blind Randomized Clinical Trial, International Journal of Preventive Medicine (2014)
46. Determinants of Hypovitaminosis D in Pregnant Women and Their Newborns in a Sunny Region, International Journal of Endocrinology (2013)
47. Association Between Dietary Phytochemical Index and Neonatal Thyroid Function, Journal of pregnancy (2024)
48. The Relations Between Dietary Antioxidant Vitamins Intake and Oxidative Stress in Follicular Fluid and Art Outcomes, Iranian Journal of Reproductive Medicine (2015)
49. The Relationship of the Serum Level of Osteoprotegerin and Bone Mineral Density in Postmenopausal Women, Journal of Isfahan Medical School (2015)
50. The Effects of Vitamin D Plus Calcium Supplementation on Metabolic Profiles, Biomarkers of Inflammation, Oxidative Stress and Pregnancy Outcomes in Pregnant Women at Risk for Pre-Eclampsia, Journal of human nutrition and dietetics : the official journal of the British Dietetic Association (2016)