Isfahan University of Medical Sciences

Science Communicator Platform

Stay connected! Follow us on X network (Twitter):
Share this content! On (X network) By
The Incidence of Congenital Hypothyroidism and Its Determinants From 2012 to 2014 in Shadegan, Iran: A Case-Control Study Publisher Pubmed



Keshavarzian E1, 2, 3 ; Valipoor AA1, 2, 3 ; Maracy MR1, 2, 3
Authors
Show Affiliations
Authors Affiliations
  1. 1. Department of Epidemiology and Biostatistics, School of Public Health, Isfahan University of Medical Sciences, Isfahan, Iran
  2. 2. Department of Epidemiology and Biostatistics, School of Public Health, Isfahan University of Medical Sciences, Isfahan, Iran
  3. 3. Department of Epidemiology and Biostatistics, School of Public Health, Isfahan University of Medical Sciences, Isfahan, Iran

Source: Epidemiology and health Published:2016


Abstract

OBJECTIVES: Congenital hypothyroidism (CH) is one of the major causes of preventable mental retardation in infants. The aim of this study was to determine the incidence of CH in Shadegan, Khuzestan Province, Iran from 2012 to 2014 and to identify the risk factors associated with CH.; METHODS: A total of 203 cases were confirmed from 2012 to 2014 in Shadegan, with 66, 86, and 51 patients reported in 2012, 2013, and 2014, respectively. A total of 3,900, 3,991, and 4,050 live births occurred in 2012, 2013, and 2014, respectively. The controls (n=657) were selected using a random number table, and a case-control study was carried out to determine the risk factors for neonatal CH, including demographic, environmental, and medical factors.; RESULTS: The incidence of CH was 17.0 per 1,000 live births in 2012, 21.5 per 1,000 live births in 2013, and 12.6 per 1,000 live births in 2014. This study showed that the likelihood of CH in children born to parents with a history of consanguineous marriage was 2.41 times greater than in children born to parents with no such history (odds ratio, 2.41; 95% confidence interval [CI], 1.65 to 3.53). This study also found that CH was 3.4 times more likely (95% CI, 2.29 to 5.20) in infants born in urban settings than in infants born in rural areas.; CONCLUSIONS: The incidence of CH in Shadegan from 2012 to 2014 was approximately 17 times greater than the expected incidence in Iran. CH was associated with a history of consanguineous marriage and urbanization.
Related Docs
View other Related Docs
1. Prevalence of Permanent Congenital Hypothyroidism in Isfahan-Iran, International Journal of Preventive Medicine (2013)
2. Congenital Hypothyroidism in Different Cities of the Isfahan Province: A Descriptive Retrospective Study, Journal of Education and Health Promotion (2019)
3. Outcome of Congenitally Hypothyroid Screening Program in Isfahan: Iran From Prevention to Treatment, International Journal of Preventive Medicine (2010)
4. Parental Consanguinity Among Parents of Neonates With Congenital Hypothyroidism in Isfahan, Eastern Mediterranean Health Journal (2007)
5. Prevalence of Transient Congenital Hypothyroidism in Central Part of Iran, Journal of Research in Medical Sciences (2013)
6. Prevalence of Concurrent Congenital Disabilities in Infants With Congenital Hypothyroidism: A Systematic Review, Journal of Pediatrics Review (2024)
7. Congenital Hypothyroidism; Is There Any Familial Component?, Journal of Isfahan Medical School (2009)
8. Prevalence of Congenital Hypothyroidism in Isfahan, Iran: Results of a Survey on 20,000 Neonates, Hormone Research (2004)
Experts (# of related papers)
View all Related Experts
Mahin Hashemipour (48)
Silva Hovsepian (34)
Other Related Docs
9. Scrutiny Relationship Between Distributions of Hypothyroidism With Environmental Iron Deficiency in Isfahan Province, Iran, Journal of Isfahan Medical School (2011)
10. Investigating the Incidence Rate and Geographical Distribution of Congenital Hypothyroidism Among Neonates in Isfahan Province Using Geographic Information System (Gis) Between 2002 and 2015, Journal of Pediatric Endocrinology and Metabolism (2020)
11. Screening of Congenital Hypothyroidism in Preterm, Low Birth Weight and Very Low Birth Weight Neonates: A Systematic Review, Pediatrics and Neonatology (2018)
12. The Descriptive Findings of Growth Status Among Children With Congenital Hypothyroidism Referred to Isfahan Endocrine and Metabolism Research Center, Journal of Isfahan Medical School (2012)
13. The Association Between Familial and Environmental Factors and Prevalence of Congenital Hypothyroidism in Center of Iran, Environmental Science and Pollution Research (2021)
14. Permanent and Transient Congenital Hypothyroidism in Isfahan-Iran, Journal of Medical Screening (2009)
15. Spatial Distribution of Congenital Hypothyroidism, Archives of Iranian Medicine (2021)
16. Effect of Diagnostic and Treatment Factors on Growth Development of Children With Congenital Hypothyroidism: A Prospective Longitudinal Study, Iranian Journal of Endocrinology and Metabolism (2015)
17. The Longitudinal Growth Trajectory of Children With Congenital Hypothyroidism During the First 3 Years of Life, European Journal of Pediatrics (2024)
18. Seasonal Variation in the Incidence of Congenital Hypothyroidism in Isfahan, Iran, Saudi Medical Journal (2007)
19. Growth Development in Children With Congenital Hypothyroidism: The Effect of Screening and Treatment Variables—A Comprehensive Longitudinal Study, Endocrine (2016)
20. Relative Frequency of Thyroid Disorders in Pregnant Women at a Maternity Clinic in Isfahan, Iran, Journal of Isfahan Medical School (2012)
21. Epidemiology of Neonatal Congenital Hypothyroidism During 2011-2017, Journal of Critical Reviews (2020)
22. Thyroid Dysfunction in Very-Low-Birth-Weight Premature Neonates: A Systematic Review of Published Evidence, Journal of Isfahan Medical School (2017)
23. Intelligence Quotient in Children With Congenital Hypothyroidism: The Effect of Diagnostic and Treatment Variables, Journal of Research in Medical Sciences (2013)
24. Congenital Cardiac Malformations in Congenital Hypothyroid Patients in Isfahan, Journal of Research in Medical Sciences (2006)
25. The Role of Maternal Tsh Receptor Blocking Antibody in the Etiology of Congenital Hypothyroidism in Isfahan, Journal of Isfahan Medical School (2011)
26. Potential Mutations of Thyroid Peroxidase Gene in Children With Congenital Hypothyroidism in Isfahan Province, Iranian Journal of Endocrinology and Metabolism (2010)
27. Age of Menarche and Final Height in Patients With Permanent Congenital Hypothyroidism, Annals of Pediatric Endocrinology and Metabolism (2024)
28. Urine and Milk Iodine Concentrations in Healthy and Congenitally Hypothyroid Neonates and Their Mothers, Endokrynologia Polska (2010)
29. Evaluation of the Tsh Threshold in Neonatal Screening for Congenital Hypothyroidism, Journal of Isfahan Medical School (2012)
30. Frequency of Thyroid Function Disorders Among a Population of Very-Low-Birth-Weight Premature Infants, Iranian Journal of Neonatology (2016)
31. Does the Prevalence of Hearing Impairment Differ in Children With Congenital Hypothyroidism and Healthy Children in Isfahan?, Journal of Isfahan Medical School (2007)
32. Sonographic Assessment of Congenitally Hypothyroid Children in Iran, Endokrynologia Polska (2010)
33. Usefulness of Ultrasonography in the Diagnosis of the Etiology of Congenital Hypothyroidism Comparing With Radioisotope Scanning, Iranian Journal of Endocrinology and Metabolism (2009)
34. The Relationship Between Hypothyroidism and Preeclampsia in Pregnant Women in an Iranian Sample, Journal of Isfahan Medical School (2017)
35. [Tc]-99M Thyroid Scintigraphy in Congenital Hypothyroidism Screening Program, Journal of Tropical Pediatrics (2006)
36. Thyroid Function Abnormalities Among First-Degree Relatives of Iranian Congenital Hypothyroidism Neonates, Pediatrics International (2010)
37. The Role of Ultrasonography in Primary Congenital Hypothyroidism, Journal of Research in Medical Sciences (2011)
38. Thyroid Abnormalities Among First-Degree Relatives of Children With Congenital Hypothyroidism: An Ultrasound Survey, Hormone Research (2008)
39. Guideline for the Treatment of Hypothyroidism in Prematurity, International Journal of Preventive Medicine (2021)
40. Rate of Recalls in Congenital Hypothyroidism Based Upon a Regional Survey in Isfahan, Iran, Using Serum T4 and Tsh Analyses: Comparison of Two Different Recall Methods, Hormone Research (2005)
41. The Consensus on the Diagnosis and Management of Congenital 2 Hypothyroidism in Term Neonates, International Journal of Preventive Medicine (2023)
42. Different Aspects of Kidney Function in Well-Controlled Congenital Hypothyroidism, JCRPE Journal of Clinical Research in Pediatric Endocrinology (2012)
43. Thyroid Volume and Nodular and Diffuse Thyroid Diseases by Ultrasonography in Pregnant Women: A Case-Control Study, Journal of Research in Medical Sciences (2020)
44. Prevalence of Pre-Pregnancy Risk Factors and Its Relationship With Preconception Care in Isfahan- Iran, International Journal of Pediatrics (2017)
45. Mutations of Dual Oxidase 2 (Duox2) Gene Among Patients With Permanent and Transient Congenital Hypothyroidism, Pakistan Journal of Medical Sciences (2012)
46. Thyroid-Stimulating Hormone (Tsh) Serum Levels and Risk of Spontaneous Abortion: A Prospective Population-Based Cohort Study, Clinical Endocrinology (2019)
47. Thyroid Function Test Reference Ranges in the First Trimester of Gestation and Pregnancy Outcomes: Protocol and Preliminary Results for Cohort Population-Based Study Isfahan, Iran, Journal of Research in Medical Sciences (2018)
48. Neonate, Infant, and Child Mortality in North Africa and Middle East by Cause: An Analysis for the Global Burden of Disease Study 2019, Archives of Iranian Medicine (2022)
49. Von Willebrand Factor, and Soluble Intercellular and Vascular Cell Adhesion Molecules As Indices of Endothelial Activation in Patients With Congenital Hypothyroidism, Hormone Research in Paediatrics (2011)
50. Systematic Review and Meta-Analysis of Levothyroxine Effect on Blood Pressure in Patients With Subclinical Hypothyroidism, Current Problems in Cardiology (2024)