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Effect of Ginger Supplementation on Liver Enzymes: A Systematic Review and Meta-Analysis Publisher



Shoaibinobarian N1 ; Riahi R2 ; Heidaribeni M3 ; Kelishadi R2
Authors
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Authors Affiliations
  1. 1. Department of Nutrition, School of Medical Sciences and Technologies, Islamic Azad University, Science and Research Branch, Tehran, Iran
  2. 2. Department of Pediatrics, Child Growth and Development Research Center, Research Institute for Primordial Prevention of Non-Communicable Disease, Isfahan University of Medical Sciences, Isfahan, Iran
  3. 3. Department of Nutrition, Child Growth and Development Research Center, Research Institute for Primordial Prevention of Non-Communicable Disease, Isfahan University of Medical Sciences, Isfahan, Iran

Source: Current Nutrition and Food Science Published:2024


Abstract

Background: Ginger (Zingiber officinale), as one of the herbal medicines, has high antioxidant activity. It may have protective effects against hepatotoxicity. This study seeks to perform a systematic review and meta-analysis on the impact of ginger on liver enzymes. Methods: The present systematic review and meta-analysis study adhered to the guidelines outlined in the PRISMA 2020 statement. A comprehensive literature search was carried out in the Medline database (PubMed), Google Scholar, Embase, Scopus, Web of Science, and Cochrane Library until the conclusion of February 2021. All interventional animal studies were included. The selected studies were the ones that examined the impact of ginger on serum liver enzymes. Results: Out of 741 articles, 39 studies were incorporated into the systematic review and meta-analysis. The pooled results suggested that ginger significantly reduced alanine aminotransferase (ALT) (standardized mean difference (SMD): 2.52, 95% confidence interval (CI): 2.12 to 2.93), aspartate aminotransferase (AST) (SMD: 3.03, 95% CI: 2.48 to 3.58), and alkaline phosphatase (ALP) (SMD: 2.10, 95% CI: 1.60 to 2.60). Conclusion: Ginger has favorable effects on liver enzymes. It shows potential as a beneficial complementary therapy for higher levels of ALT, AST, and ALP because of its useful effects and negligible side effects. © 2024 Bentham Science Publishers.
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