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Ginger As an Anticolorectal Cancer Spice: A Systematic Review of in Vitro to Clinical Evidence Publisher



Nachvak SM1 ; Soleimani D1, 2 ; Rahimi M3 ; Azizi A3 ; Moradinazar M4 ; Rouhani MH5 ; Halashi B6 ; Abbasi A1 ; Miryan M1, 7
Authors
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Authors Affiliations
  1. 1. Nutritional Sciences Department, School of Nutritional Sciences and Food Technology, Kermanshah University of Medical Sciences, Kermanshah, Iran
  2. 2. Research Center of Oils and Fats, Kermanshah University of Medical Sciences, Kermanshah, Iran
  3. 3. Faculty of Medicine, Department of Nutrition, Kermanshah University of Medical Sciences, Kermanshah, Iran
  4. 4. Social Development and Health Promotion Research Center, Kermanshah University of Medical Science, Kermanshah, Iran
  5. 5. Food Security Research Center, Health Research Institute, Department of Clinical Nutrition, School of Nutrition and Food Science, Isfahan University of Medical Sciences, Isfahan, Iran
  6. 6. Department of Community Nutrition, School of Nutrition and Food Sciences, Kidney Diseases Research Center, Isfahan University of Medical Sciences, Isfahan, Iran
  7. 7. Student Research Committee, Kermanshah University of Medical Science, Kermanshah, Iran

Source: Food Science and Nutrition Published:2023


Abstract

Ginger and its derivatives have been shown to be effective in the prevention and treatment of cancer. We undertook a systematic review to answer the question of whether ginger has a role in modifying the biomarkers of cancer in cell culture conditions and on colorectal cancer in randomized clinical trials. We performed a comprehensive search of the literature from Scopus, Embase, Web of Science, PubMed, Cochrane central register of controlled trials, and Cochrane database of systematic reviews. At first, all 12 papers studied the effect of ginger or its derivatives on cell culture conditions. The results of cell culture studies show that ginger has a powerful role in inducing apoptosis. In the second part, five studies of clinical trials were analyzed. By analyzing antitumor markers of clinical trials, ginger increased some anticancer markers but performed poorly in inducing some anticancer markers. This systematic review showed that the consumption of ginger extract has the potential to prevent and treat colorectal cancer but this ability is weak. © 2022 The Authors. Food Science & Nutrition published by Wiley Periodicals LLC.
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