Body Composition and Serum Levels of Matrix Metalloproteinase-9, Adiponectin and Amp-Activated Protein Kinase in Breast Cancer Survivors Publisher



Babaei Z¹ ; Parsian H² ; Korani B³ ; Mostafazadeh A² ; Moslemi D⁴
Source: Journal of Research in Medical Sciences Published:2022

Abstract

Background: Available data suggest that obesity is related to changes in the several adipocyte-derived proteins levels, which are involved in cancer recurrence. The purpose of this work was to investigate the correlation between obesity with metalloproteinase-9 (MMP-9), adiponectin and adiponectin and AMP-activated protein kinase (AMPK) levels by comparing serum levels of MMP-9, AMPK in normal weight and obese breast cancer survivors. Materials and Methods: In this cross-sectional study, 30 normal weight breast cancer survivors (body mass index [BMI] 18.5-25 kg/m 2) and 30 obese breast cancer survivors (BMI ≥30 kg/m 2) were investigated. Anthropometric parameters and serum levels of MMP-9, adiponectin, and AMPK were compared between the two groups. Results: No differences were detected in the serum levels of MMP-9, adiponectin, and AMPK in obese patients and normal weight patients (P > 0.05). There were no correlations between MMP-9, adiponectin, and AMPK levels with anthropometric measurements in two groups (P > 0.05). Conclusion: We found that there was a lack of correlation between obesity measures and serum levels of MMP-9, adiponectin, and AMPK. In breast cancer survivors, it seems that circulating levels of adiponectin, AMPK, and MMP-9 do not change in obesity state. © 2022 Wolters Kluwer Medknow Publications. All rights reserved.