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The Effect of Omega-3 Supplementation on Serum Levels of Ykl-40, Bmp-4, and Ox-Ldl in Men With Coronary Artery Disease: A Randomized Double-Blind Placebo-Controlled Trial Publisher



Samavat S1 ; Javanbakht MH1 ; Nematipour E2 ; Zarei M1 ; Honarvar NM1 ; Ramezani A3 ; Mohammadi H4 ; Djalali M1
Authors
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Authors Affiliations
  1. 1. Department of Cellular and Molecular Nutrition, School of Nutrition Sciences and Dietetics, Tehran University of Medical Sciences, Poorsina Street, Enghelab Avenue, Tehran, Iran
  2. 2. Department of Cardiology, Tehran Heart Center, Tehran University of Medical Sciences, Tehran, Iran
  3. 3. Department of Basic sciences and Nutrition, Health Sciences Research Center, School of Public Health, Mazandaran University of Medical Sciences, Sari, Iran
  4. 4. Department of Clinical Nutrition, School of Nutrition and Food Science, Isfahan University of Medical Sciences, Isfahan, Iran

Source: Progress in Nutrition Published:2019


Abstract

Objective: Bone morphogenic protein-4 (BMP-4), oxidized low density lipoprotein (ox-LDL), and YKL-40 are the potential biomarkers which may causes inflammation and cardiovascular disease. Omega-3 fatty acid-rich diets may have anti-inflammatory effects. This study was designed to determine the effects of omega-3 fatty acid supplementation on serum YKL-40, BMP-4, and ox-LDL levels in men with coronary artery disease (CAD). Methods: The current study was a randomized, placebo-controlled, double-blind parallel-group clinical trial that involved 42 male patients with CAD. The volunteers were randomly allocated into two groups to receive 4 g omega-3 (containing 720 mg EPA plus 480 mg DHA) supplements (n = 21) or placebo (n = 21) per day for 8 weeks. Fasting blood samples were taken at the beginning and end of the trial to quantify serum levels of ox-LDL, YKL-40 and BMP-4 concentrations. Result: The results identified that omega-3 fatty acid supplementation for 8 weeks had a noticeable effect on serum ox-LDL (P = 0.03), YKL-40 (P = 0.01), and BMP-4 (P = 0.01) concentrations between groups. A significant difference was found between placebo and omega-3 supplementation groups only for BMP-4 (P = 0.046) after removing counfounding effects of Vitamin C and carbohydrates. Conclusions: The results of this study indicate that omega-3 supplementation decreased serum BMP-4 significantly. Serum YKL-40 correlated with ox-LDL before intervention. Further study is recommended to elucidate the exact mechanisms for this process. © Mattioli 1885.
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