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Immunodeficiencies Affecting Cellular and Humoral Immunity Publisher



Chavoshzadeh Z1 ; Darougar S2 ; Momen T3 ; Esmaeilzadeh H4 ; Abolhassani H5, 6 ; Cheraghi T7 ; Van Der Burg M8 ; Van Zelm M9
Authors
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Authors Affiliations
  1. 1. Department of Immunology and Allergy, Mofid’s Children Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran
  2. 2. Department of Pediatrics, Tehran Medical Sciences Branch, Islamic Azad University, Tehran, Iran
  3. 3. Division of Allergy and Clinical Immunology, Isfahan University of Medical Sciences, Isfahan, Iran
  4. 4. Allergy Research Center, Shiraz University of Medical Sciences, Shiraz, Iran
  5. 5. Division of Clinical Immunology, Department of Laboratory Medicine, Karolinska Institute, Stockholm, Sweden
  6. 6. Research Center for Immunodeficiencies, Children’s Medical Center Hospital, Tehran University of Medical Sciences, Tehran, Iran
  7. 7. Department of Pediatrics, 17th Shahrivar Hospital, School of Medicine, Guilan University of Medical Sciences, Rasht, Iran
  8. 8. Department of Pediatrics, Laboratory for Immunology, Leiden University Medical Center, Leiden, Netherlands
  9. 9. Department of Immunology and Pathology, Central Clinical School, Monash University, Melbourne, VIC, Australia

Source: Inborn Errors of Immunity: A Practical Guide Published:2021


Abstract

Combined immunodeficiencies (CIDs) are the result of defective development or function of T cells. As the most severe form of primary immunodeficiency disorders (PID), CIDs are characterized by a susceptibility to infection, particularly from opportunistic organisms, which leads to severe morbidity and mortality. A subpopulation of patients has additional syndromic features caused by the function of the affected gene beyond the immune system. In this chapter, we will focus on nonsyndromic CIDs. © 2021 Elsevier Inc. All rights reserved.
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