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Nutritional Vitamin D Supplementation in Chronic Hemodialysis: An Uncontrolled Open-Label Trial Publisher



Shahidi S1 ; Mortazavi M2 ; Bakhtiari M3 ; Mirhoseini M4 ; Ghasemi G5
Authors
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Authors Affiliations
  1. 1. Isfahan Kidney Diseases Research Center, Internal Medicine Department, Khorshid Hospital, Isfahan University of Medical Sciences, Isfahan, Iran
  2. 2. Isfahan Kidney Diseases Research Center, Internal Medicine Department, Al-Zahra Hospital, Isfahan University of Medical Sciences, Isfahan, Iran
  3. 3. Department of Gynecology and Obstetrics, Shohadaye Tajrish Hospital, Shahid Beheshti Medical University, Tehran, Iran
  4. 4. Department of Orthopedic Surgery, Shahid Madani Hospital, Alborz University of Medical Science, Karaj, Iran
  5. 5. Isfahan Kidney Diseases Research Center, Isfahan University of Medical Sciences, Isfahan, Iran

Source: Journal of Education and Health Promotion Published:2023


Abstract

The present study was evaluated by the incidence of vitamin D deficiency and management of hemodialysis (HD) patients with low doses of vitamin D over 6 months. This uncontrolled open-label trial was fulfilled in descriptive and then analytical phases from 2008 to 2010 recruiting chronic HD patients in our province. For this purpose, 169 patients undergoing regular HD were randomly selected and their vitamin D level was measured. Then, 54 patients with vitamin D levels less than 30 ng/mL entered the second phase. This group received 50,000 IU vitamin D3 monthly for 6 months. The mean vitamin D level in 169 patients was 21.73 ± 20.27 ng/mL. As well, 62.7% had vitamin D levels less than 30 ng/mL. Following the six-month intervention, mean vitamin D levels elevated significantly from 17.03 ± 7.4 to 42.8 ± 16.9 ng/mL (P <.0001). In this study, the incidence rate of vitamin D deficiency was 62.7%, lower than that in previous research in patients undergoing chronic HD. Vitamin D3 administration at lower doses than healthy people could significantly increase vitamin D level. © 2023 Wolters Kluwer Medknow Publications. All rights reserved.
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