Isfahan University of Medical Sciences

Science Communicator Platform

Stay connected! Follow us on X network (Twitter):
Share this content! On (X network) By
Effects of Vitamin D on Retinal Nerve Fiber Layer in Vitamin D Deficient Patients With Optic Neuritis: Preliminary Findings of a Randomized, Placebo-Controlled Trial



Salari M1 ; Janghorbani M2 ; Etemadifar M1 ; Dehghani A3 ; Razmjoo H3 ; Naderian G3
Authors
Show Affiliations
Authors Affiliations
  1. 1. Department of Neurology, Isfahan University of Medical Sciences, Isfahan, Iran
  2. 2. Department of Epidemiology and Biostatistics, Isfahan University of Medical Sciences, Isfahan, Iran
  3. 3. Department of Ophthalmology, Isfahan University of Medical Sciences, Isfahan, Iran

Source: Journal of Research in Medical Sciences Published:2015

Abstract

Background: There is accumulating evidence for a possible protective role of vitamin D in the development and disease course of multiple sclerosis. Whether vitamin D is also effective in treating patients with optic neuritis (ON) is not known. The aim of this study was to evaluate the effect of oral vitamin D on the thickness of retinal nerve fiber layer (RNFL) in vitamin D deficient patients with ON by optical coherence tomography. Materials and Methods: A Phase II placebo-controlled randomized clinical trial conducted between July 2011 and November 2012 included 52 patients with confirmed unilateral ON aged 15-38 years and low serum 25-hydroxyvitamin D levels. The main outcome measures were changes in thickness of RNFL and macula 6 months after treatment. Patients were randomly allocated to receive 6 months of treatment with adding either 50,000 IU/ week vitamin D or placebo. Results: In the 27 patients treated with vitamin D, the mean (standard deviation [SD]) thickness of RNFL decreased from 111.3 (18.9) µm at baseline to 91.4 (13.3) at the end of study period (P < 0.001). Correspondingly, in the 25 patients treated with placebo, the mean (SD) thickness of RNFL decreased from 113.7 (21.5) µm at baseline to 96.1 (12.3) at the end of study period (P < 0.01). In both groups, the mean thickness of the macula did not changed (P > 0.05). Average thickness of RNFL at the end of trial did not differ between groups. Conclusion: Adding vitamin D to routine disease therapy had no significant effect on the thickness of RNFL or macula in patients with ON. This trial is registered on www.clinicaltrials. gov (ID NCT01465893). © 2015, Isfahan University of Medical Sciences(IUMS). All rights reserved.
Related Docs
View other Related Docs
1. Preventive Effect of Vitamin D3 Supplementation on Conversion of Optic Neuritis to Clinically Definite Multiple Sclerosis: A Double Blind, Randomized, Placebo-Controlled Pilot Clinical Trial, Acta Neurologica Belgica (2013)
2. Serum Levels of 25(Oh) Vitamin D3 and Clinical Manifestation of First Demyelinating Attack, Journal of Isfahan Medical School (2018)
3. Iranian Consensus on Use of Vitamin D in Patients With Multiple Sclerosis, BMC Neurology (2016)
4. Vitamin D Supplementation Could Limit T Helper-17 Response in Multiple Sclerosis, Clinical and Experimental Neuroimmunology (2014)
5. Vitamin D Level in Iranian Patients With Neuromyelitis Optica, Journal of Isfahan Medical School (2021)
6. Short-Term Effect of High-Dose Vitamin D on the Level of Interleukin 10 in Patients With Multiple Sclerosis: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial, NeuroImmunoModulation (2015)
7. Effect of High Dose Vitamin D Intake on Interleukin-17 Levels in Multiple Sclerosis: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial, Journal of Neuroimmunology (2015)
8. 25-Hydroxyvitamin D Concentrations in Patients With Optic Neuritis As a Clinically Isolated Syndrome and Healthy Controls, International Journal of Preventive Medicine (2012)
Experts (# of related papers)
View all Related Experts
Vahid Shaygannejad (16)
Fereshteh Ashtari (15)
Other Related Docs
9. A Comparative Study of 25 (Oh) Vitamin D Serum Levels in Patients With Multiple Sclerosis and Control Group in Isfahan, Iran, International Journal of Preventive Medicine (2010)
10. High Dose Vitamin D Intake and Quality of Life in Relapsing-Remitting Multiple Sclerosis: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial, Neurological Research (2016)
11. Optical Coherence Tomography in Neuromyelitis Optica Spectrum Disorder and Multiple Sclerosis: A Population-Based Study, Multiple Sclerosis and Related Disorders (2021)
12. Association Between Vitamin D and Dry Eye Disease: A Systematic Review and Meta-Analysis of Observational Studies, Contact Lens and Anterior Eye (2020)
13. Association Between Sun Exposure, Vitamin D Intake, Serum Vitamin D Level, and Immunoglobulin G Level in Patients With Neuromyelitis Optica Spectrum Disorder, International Journal of Preventive Medicine (2018)
14. Efficacy of Adding Vitamin D Supplementation to Interferon Β-1 in Multiple Sclerosis, Journal of Isfahan Medical School (2016)
15. Serum Levels of Interleukin-6 and Vitamin D at the Onset of Multiple Sclerosis and Neuromyelitis Optica: A Pilot Study, Journal of Research in Medical Sciences (2022)
16. The Effect of Vitamin D Supplementation on the Outcome of Treatment With Bevacizumab in Diabetic Macular Edema: A Randomized Clinical Trial, International Ophthalmology (2022)
17. Vitamin D Deficiency in Patients With Retinal Vein Occlusion: A Systematic Review and Meta-Analysis, International Journal of Retina and Vitreous (2024)
18. The Effect of Vitamin D Supplementation in Disease Activity of Systemic Lupus Erythematosus Patients With Vitamin D Deficiency: A Randomized Clinical Trial, Journal of Research in Medical Sciences (2017)
19. The Relation of Vitamin D Deficiency and Activity of Systematic Lupus Erythematosis, Journal of Isfahan Medical School (2016)
20. Effect of Vitamin D Deficiency Treatment on Thyroid Function and Autoimmunity Markers in Hashimoto’S Thyroiditis: A Double-Blind Randomized Placebo-Controlled Clinical Trial, Journal of Research in Medical Sciences (2017)
21. Vitamin D Deficiency Associated With Disease Activity in Patients With Inflammatory Bowel Diseases, Digestive Diseases and Sciences (2015)
22. A Survey of Vitamin D Status in Patients With Degenerative Diseases of the Spine, Asian Spine Journal (2016)
23. The Relation Between Vitamin D Status With Fatigue and Depressive Symptoms of Multiple Sclerosis, Journal of Research in Medical Sciences (2013)
24. The Effects of Different Kinds of Nutrition and Functional Foods on Multiple Sclerosis, Current Nutrition and Food Science (2020)
25. Effect of Different Treatments on Retinal Thickness Changes in Patients With Multiple Sclerosis: A Review, CNS Neuroscience and Therapeutics (2025)
26. Effect of Vitamin D Supplement on Mood Status and Inflammation in Vitamin D Deficient Type 2 Diabetic Women With Anxiety: A Randomized Clinical Trial, International Journal of Preventive Medicine (2019)
27. Diagnosis and Management of Neuromyelitis Optica Spectrum Disorder (Nmosd) in Iran: A Consensus Guideline and Recommendations, Multiple Sclerosis and Related Disorders (2017)
28. The Effect of Vitamin D Supplementation on Serum Levels of Fibroblast Growth Factor- 23: A Systematic Review and Meta-Analysis of Randomized Controlled Trials, Journal of Steroid Biochemistry and Molecular Biology (2022)
29. Comparison of Sun Exposure Versus Vitamin D Supplementation for Pregnant Women With Vitamin D Deficiency, Journal of Maternal-Fetal and Neonatal Medicine (2019)
30. Serum Level of Vitamin D and Distal Radius Fractures: A Case-Control Study, Journal of Isfahan Medical School (2017)
31. Effects of Vitamin D Supplementation on 8-Hydroxydeoxy Guanosine and 3-Nitrotyrosine in Patients With Type 2 Diabetes: A Randomized Clinical Trial, Progress in Nutrition (2019)
32. Vitamin D Supplementation for Premenstrual Syndrome-Related Inflammation and Antioxidant Markers in Students With Vitamin D Deficient: A Randomized Clinical Trial, Scientific Reports (2019)
33. Comparing the Effectiveness of Vitamin D Plus Iron Vs Vitamin D on Depression Scores in Anemic Females: Randomized Triple-Masked Trial, Medical Journal of the Islamic Republic of Iran (2019)
34. Vitamin D3 and Estradiol Alter Pad2 Expression and Activity Levels in C6 Glioma Cells, Multiple Sclerosis and Related Disorders (2021)
35. The Association Between Dietary Inflammatory Index and Risk of Neuromyelitis Optica Spectrum Disorder: A Case–Control Study, Nutritional Neuroscience (2024)
36. A Comparison of the Effect of Supplementation and Sunlight Exposure on Serum Vitamin D and Parathyroid Hormone: A Systematic Review and Meta-Analysis, Critical Reviews in Food Science and Nutrition (2020)
37. The Effects of Vitamin D Supplementation on Adhd (Attention Deficit Hyperactivity Disorder) in 6–13 Year-Old Students: A Randomized, Double-Blind, Placebo-Controlled Study, European Journal of Integrative Medicine (2019)
38. Calcium-Vitamin D Cosupplementation Influences Circulating Inflammatory Biomarkers and Adipocytokines in Vitamin D-Insufficient Diabetics: A Randomized Controlled Clinical Trial, Journal of Clinical Endocrinology and Metabolism (2014)
39. The Effects of Vitamin D Supplementation on Inflammatory Biomarkers in Patients With Abnormal Glucose Homeostasis: A Systematic Review and Meta-Analysis of Randomized Controlled Trials, Pharmacological Research (2021)
40. Color Blindness Among Multiple Sclerosis Patients in Isfahan, Journal of Research in Medical Sciences (2012)
41. The Effect of Vitamin D Supplement on Outcomes in Patients With Traumatic Injuries Hospitalized in Intensive Care Unit: A Clinical Trial Study, Journal of Isfahan Medical School (2020)
42. A Double-Blind, Placebo-Controlled Trial of Adding Erythropoietin to Intravenous Methylprednisolone for the Treatment of Unilateral Acute Optic Neuritis of Unknown or Demyelinative Origin, Graefe's Archive for Clinical and Experimental Ophthalmology (2015)
43. Serum Vitamin D Levels in Patients With Chronic Urticaria and Its Comparison With Healthy Individuals in Isfahan City, Iran, Journal of Isfahan Medical School (2020)
44. The Beneficial Effects of Vitamin D3 on Reducing Antibody Titers Against Epstein-Barr Virus in Multiple Sclerosis Patients, Cellular Immunology (2015)
45. Active Form and Reservoir Form of Vitamin D in Children With Acute Lower Respiratory Infections and Its Association With Severity of the Infection, Archives of Pediatric Infectious Diseases (2019)
46. Comparing the Improvement of Unstable Vitiligo in Patients Treated by Topical Puva-Therapy Alone, Topical Puva-Therapy and Oral Vitamin D, and Topical Puva-Therapy and Oral Vitamin D and Vitamin B12, Journal of Isfahan Medical School (2017)
47. Diagnosis and Classification of Optic Neuritis, The Lancet Neurology (2022)
48. Increased Serum Level of Il-37 in Patients With Multiple Sclerosis and Neuromyelitis Optica, Acta Neurologica Belgica (2015)
49. Evaluating the Effect of Adding Fish Oil to Fingolimod on Tnf-Α Il1β Il6, and Ifn-Γ in Patients With Relapsing-Remitting Multiple Sclerosis: A Double-Blind Randomized Placebo-Controlled Trial, Clinical Neurology and Neurosurgery (2017)
50. Serum Vitamin D Levels in Relation to Schizophrenia: A Systematic Review and Meta-Analysis of Observational Studies, Journal of Clinical Endocrinology and Metabolism (2014)