Highlighting Roles of Autophagy in Human Diseases: A Perspective From Single-Cell Rna Sequencing Analyses

Highlighting Roles of Autophagy in Human Diseases: A Perspective From Single-Cell Rna Sequencing Analyses Publisher Pubmed

Khalafiyan A¹ ; Fadaie M¹ ; Khara F² ; Zarrabi A^{3, 4, 5} ; Moghadam F¹ ; Khanahmad H¹ ; Cordani M^{6, 7} ; Boshtam M⁸

Show Affiliations

1. Department of Genetics and Molecular Biology, Faculty of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran
2. Department of Biology, Faculty of Sciences, Shahid Chamran University of Ahvaz, Ahvaz, Iran
3. Department of Biomedical Engineering, Faculty of Engineering and Natural Sciences, Istinye University, Istanbul, 34396, Turkiye
4. Graduate School of Biotechnology and Bioengineering, Yuan Ze University, Taoyuan, 320315, Taiwan
5. Department of Research Analytics, Saveetha Dental College and Hospitals, Saveetha Institute of Medical and Technical Sciences, Saveetha University, Chennai, 600 077, India
6. Department of Biochemistry and Molecular Biology, Faculty of Biological Sciences, Complutense University of Madrid, Madrid, 28040, Spain
7. Instituto de Investigaciones Sanitarias San Carlos (IdISSC), Madrid, 28040, Spain
8. Isfahan Cardiovascular Research Center, Cardiovascular Research Institute, Isfahan University of Medical Sciences, Isfahan, Iran

Source: Drug Discovery Today Published:2024

Abstract

Autophagy, the lysosome-driven breakdown of intracellular components, is pivotal in regulating eukaryotic cellular processes and maintaining homeostasis, making it physiologically important even under normal conditions. Cellular mechanisms involving autophagy include the response to nutrient deprivation, intracellular quality control, early development, and cell differentiation. Despite its established health significance, the role of autophagy in cancer and other diseases remains complex and not fully understood. A comprehensive understanding of autophagy is crucial to facilitate the development of novel therapies and drugs that can protect and improve human health. High-throughput technologies, such as single-cell RNA sequencing (scRNA-seq), have enabled researchers to study transcriptional landscapes at single-cell resolution, significantly advancing our knowledge of autophagy pathways across diverse physiological and pathological contexts. This review discusses the latest advances in scRNA-seq for autophagy research and highlights its potential in the molecular characterization of various diseases. © 2024 The Author(s)

Related Docs

View other Related Docs

1. Autophagy: An Overview of Molecular Mechanisms and Its Therapeutic Implications for Health and Disease, Journal of Mazandaran University of Medical Sciences (2024)

2. The Potential of Targeting Autophagy-Related Non-Coding Rnas in the Treatment of Alzheimer’S and Parkinson’S Diseases, Cellular and Molecular Neurobiology (2024)

3. Exercise-Activated Hepatic Autophagy Combined With Silymarin Is Associated With Suppression of Apoptosis in Rats Subjected to Dexamethasone Induced- Fatty Liver Damage, Molecular Biology Reports (2024)

4. Autophagy and the Peroxisome Proliferator-Activated Receptor Signaling Pathway: A Molecular Ballet in Lipid Metabolism and Homeostasis, Molecular and Cellular Biochemistry (2025)

5. Epigenetic Regulation of Autophagy in Gastrointestinal Cancers, Biochimica et Biophysica Acta - Molecular Basis of Disease (2022)

6. Mechanistic Insights Into Circrna-Mediated Regulation of Pi3k Signaling Pathway in Glioma Progression, Pathology Research and Practice (2024)

7. Single Cell Rna Sequencing Improves the Next Generation of Approaches to Aml Treatment: Challenges and Perspectives, Molecular Medicine (2025)

8. An Updated Review of Contribution of Long Noncoding Rna-Neat1 to the Progression of Human Cancers, Pathology Research and Practice (2023)

Experts (# of related papers)

View all Related Experts

Hassan Dianat Moghadam (3)

Mohammadreza Sharifi (2)

Style	Citing Format
MLA	Khalafiyan A, et al.. "Highlighting Roles of Autophagy in Human Diseases: A Perspective From Single-Cell Rna Sequencing Analyses." Drug Discovery Today, vol. 29, no. 12, 2024, pp. -.
APA	Khalafiyan A, Fadaie M, Khara F, Zarrabi A, Moghadam F, Khanahmad H, Cordani M, Boshtam M (2024). Highlighting Roles of Autophagy in Human Diseases: A Perspective From Single-Cell Rna Sequencing Analyses. Drug Discovery Today, 29(12), -.
Chicago	Khalafiyan A, Fadaie M, Khara F, Zarrabi A, Moghadam F, Khanahmad H, Cordani M, Boshtam M. "Highlighting Roles of Autophagy in Human Diseases: A Perspective From Single-Cell Rna Sequencing Analyses." Drug Discovery Today 29, no. 12 (2024): -.
Harvard	Khalafiyan A et al. (2024) 'Highlighting Roles of Autophagy in Human Diseases: A Perspective From Single-Cell Rna Sequencing Analyses', Drug Discovery Today, 29(12), pp. -.
Vancouver	Khalafiyan A, Fadaie M, Khara F, Zarrabi A, Moghadam F, Khanahmad H, et al.. Highlighting Roles of Autophagy in Human Diseases: A Perspective From Single-Cell Rna Sequencing Analyses. Drug Discovery Today. 2024;29(12):-.
BibTex	@article{ author = {Khalafiyan A and Fadaie M and Khara F and Zarrabi A and Moghadam F and Khanahmad H and Cordani M and Boshtam M}, title = {Highlighting Roles of Autophagy in Human Diseases: A Perspective From Single-Cell Rna Sequencing Analyses}, journal = {Drug Discovery Today}, volume = {29}, number = {12}, pages = {-}, year = {2024} }
RIS	TY - JOUR AU - Khalafiyan A AU - Fadaie M AU - Khara F AU - Zarrabi A AU - Moghadam F AU - Khanahmad H AU - Cordani M AU - Boshtam M TI - Highlighting Roles of Autophagy in Human Diseases: A Perspective From Single-Cell Rna Sequencing Analyses JO - Drug Discovery Today VL - 29 IS - 12 SP - EP - PY - 2024 ER -

Science Communicator Platform

Authors

Authors Affiliations

Abstract