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Emerging Roles for Lncrna-Neat1 in Colorectal Cancer Publisher



Azizidoost S1 ; Ghaedrahmati F2 ; Anbiyaee O3 ; Ahmad Ali R4 ; Cheraghzadeh M5 ; Farzaneh M6
Authors
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Authors Affiliations
  1. 1. Atherosclerosis Research Center, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran
  2. 2. Department of Immunology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran
  3. 3. Cardiovascular Research Center, Nemazi Hospital, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran
  4. 4. Department of Medical Laboratory Science, College of Health Science, Lebanese French University, Kurdistan Region, Iraq
  5. 5. Department of Biochemistry, School of Medicine, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran
  6. 6. Fertility, Infertility and Perinatology Research Center, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran

Source: Cancer Cell International Published:2022


Abstract

Colorectal cancer (CRC) is the third cause of cancer death in the world that arises from the glandular and epithelial cells of the large intestine, during a series of genetic or epigenetic alternations. Recently, long non-coding RNAs (lncRNAs) has opened a separate window of research in molecular and translational medicine. Emerging evidence has supported that lncRNAs can regulate cell cycle of CRC cells. LncRNA NEAT1 has been verified to participate in colon cancer development and progression. NEAT1 as a competing endogenous RNA could suppress the expression of miRNAs, and then regulate molecules downstream of these miRNAs. In this review, we summarized emerging roles of NEAT1 in CRC cells. © 2022, The Author(s).
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