An Updated Review of Contribution of Long Noncoding Rna-Neat1 to the Progression of Human Cancers

Science Communicator Platform

Stay connected! Follow us on X network (Twitter):

Share this content! On (X network) By

An Updated Review of Contribution of Long Noncoding Rna-Neat1 to the Progression of Human Cancers Publisher Pubmed

Farzaneh M¹ ; Masoodi T² ; Ghaedrahmati F³ ; Radoszkiewicz K⁴ ; Anbiyaiee A⁵ ; Sheykhisabzehpoush M⁶ ; Rad NK⁷ ; Uddin S⁸ ; Jooybari SPM⁹ ; Khoshnam SE^{10, 11} ; Azizidoost S¹²

Show Affiliations

1. Fertility, Infertility and Perinatology Research Center, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran
2. Laboratory of Molecular and Metabolic Imaging, Cancer Research Department, Sidra Medicine, Doha, 26999, Qatar
3. Department of Immunology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran
4. Translational Platform for Regenerative Medicine, Mossakowski Medical Research Institute, Polish Academy of Sciences, Poland
5. Department of Surgery, School of Medicine, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran
6. epartment of Laboratory, Imam Khomeini Hospital Complex, Tehran University of Medical Sciences, Tehran, Iran
7. Department of Stem Cells and Developmental Biology, Cell Science Research Center, Royan Institute for Stem Cell Biology and Technology, ACECR, Tehran, Iran
8. Translational Research Institute and Dermatology Institute, Academic Health System, Hamad Medical Corporation, Doha, Qatar
9. Department of Biology, Faculty of Basic Sciences and Engineering, University of Gonbad Kavous, Golestan, Gonbad Kavus, Iran
10. Cellular and Molecular Research Center, Medical Basic Sciences Research Institute, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran
11. Persian Gulf Physiology Research Center, Medical Basic Sciences Research Institute, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran
12. Atherosclerosis Research Center, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran

Source: Pathology Research and Practice Published:2023

Abstract

Long non-coding RNAs (lncRNAs) present pivotal roles in cancer tumorigenesis and progression. Recently, nuclear paraspeckle assembly transcript 1 (NEAT1) as a lncRNA has been shown to mediate cell proliferation, migration, and EMT in tumor cells. NEAT1 by targeting several miRNAs/mRNA axes could regulate cancer cell behavior. Therefore, NEAT1 may function as a potent biomarker for the prediction and treatment of some human cancers. In this review, we summarized various NEAT1-related signaling pathways that are critical in cancer initiation and progression. © 2023

Related Docs

View other Related Docs

1. Emerging Roles for Lncrna-Neat1 in Colorectal Cancer, Cancer Cell International (2022)

2. Exploring Potential Roles of Long Non-Coding Rnas in Cancer Immunotherapy: A Comprehensive Review, Frontiers in Immunology (2024)

3. Long Non-Coding Rnas and Melanoma: From Diagnosis to Therapy, Pathology Research and Practice (2023)

4. The Pathogenic Roles of Lncrna-Taurine Upregulated 1 (Tug1) in Colorectal Cancer, Cancer Cell International (2022)

5. Potential Roles of Lncrna-Xist/Mirnas/Mrnas in Human Cancer Cells, Clinical and Translational Oncology (2023)

6. A Comprehensive Review of the Role of Lncrnas in Gastric Cancer (Gc) Pathogenesis, Immune Regulation, and Their Clinical Applications, Pathology Research and Practice (2023)

7. Non-Coding Rnas and Glioblastoma: Insight Into Their Roles in Metastasis, Molecular Therapy Oncolytics (2022)

8. Multiple Function of Lncrna Malat1 in Cancer Occurrence and Progression, Chemical Biology and Drug Design (2023)

Experts (# of related papers)

View all Related Experts

Mohammadreza Sharifi (10)

Parvaneh Nikpour (8)

Other Related Docs

9. Dysregulated Expression and Functions of Microrna-330 in Cancers: A Potential Therapeutic Target, Biomedicine and Pharmacotherapy (2022)

10. Circular Rnas: New Genetic Tools in Melanoma, Biomarkers in Medicine (2020)

11. Altered Expression of Linc-Ror in Cancer Cell Lines and Tissues, Tumor Biology (2016)

12. Melatonin Targeting Non-Coding Rnas in Cancer: Focus on Mechanisms and Potential Therapeutic Targets, European Journal of Pharmacology (2023)

13. Comprehensive Competitive Endogenous Rna Network Analysis Reveals Ezh2-Related Axes and Prognostic Biomarkers in Hepatocellular Carcinoma, Iranian Journal of Basic Medical Sciences (2022)

14. Constructing a Novel Competing Endogenous Rnas Network Based on Nr3c1 and X-Linked Inhibitor of Apoptosis Protein Genes Reveals Potential Prognostic Biomarkers in Colorectal Cancer, Journal of Research in Medical Sciences (2022)

15. A Spotlight on the Interplay Between Wnt/Β-Catenin Signaling and Circular Rnas in Hepatocellular Carcinoma Progression, Frontiers in Oncology (2023)

16. Identification of Syt10 As a Potential Prognostic Biomarker in Esophageal Cancer by Comprehensive Analysis of a Mrna-Pseudogene/Lncrna-Mirna Cerna Network, Human Gene (2023)

17. Differential Expression and Pathological Implications of Linc01089 and Linc01578 in Acute Myeloid Leukemia, Gene Reports (2025)

18. Long Noncoding Rnas in Gastric Cancer Carcinogenesis and Metastasis, Briefings in Functional Genomics (2017)

19. The Prominent Role of Mir-942 in Carcinogenesis of Tumors, Advanced Biomedical Research (2022)

20. Inhibition of Microrna Mir-222 With Lna Inhibitor Can Reduce Cell Proliferation in B Chronic Lymphoblastic Leukemia, Indian Journal of Hematology and Blood Transfusion (2017)

21. Micrornas, Long Non-Coding Rnas, and Circular Rnas and Gynecological Cancers: Focus on Metastasis, Frontiers in Oncology (2023)

22. Exploring Conserved Mrna-Mirna Interactions in Colon and Lung Cancers, Gastroenterology and Hepatology from Bed to Bench (2017)

23. Inhibition of Microrna-21 Via Locked Nucleic Acid-Anti-Mir Suppressed Metastatic Features of Colorectal Cancer Cells Through Modulation of Programmed Cell Death 4, Tumor Biology (2017)

24. The Role of Long Non-Coding Rnas in the Pathogenesis of Essential Hypertension, Current Signal Transduction Therapy (2024)

25. Mechanisms of Apoptosis-Related Non-Coding Rnas in Ovarian Cancer: A Narrative Review, Apoptosis (2025)

26. Recent Insights Into the Microrna-Dependent Modulation of Gliomas From Pathogenesis to Diagnosis and Treatment, Cellular and Molecular Biology Letters (2022)

27. Augmented Expression Levels of Lncrnas Eccebpa and Uca1 in Gastric Cancer Tissues and Their Clinical Significance, Iranian Journal of Basic Medical Sciences (2017)

28. Modulation of Long Non-Coding Rnas and Micrornas by Quercetin As a Potential Therapeutical Approach in Cancer: A Comprehensive Review, Current medicinal chemistry (2025)

29. Current Status and Perspectives Regarding Lna-Anti-Mir Oligonucleotides and Microrna Mir-21 Inhibitors As a Potential Therapeutic Option in Treatment of Colorectal Cancer, Journal of Cellular Biochemistry (2017)

30. Dna Methylation and Microrna Patterns Are in Association With the Expression of Brca1 in Ovarian Cancer, Cellular and Molecular Biology (2016)

31. Lncrna–Mirna–Mrna Networks of Gastrointestinal Cancers Representing Common and Specific Lncrnas and Mrnas, Frontiers in Genetics (2022)

32. Knockdown of Sirlnt by Antisense Lna Gapmers and Evaluation of Its Inhibitory Effect on Proliferation and Apoptosis in Mcf7 Cell Line, Indian Journal of Gynecologic Oncology (2023)

33. Unveiling Mesenchymal Stem Cells’ Regenerative Potential in Clinical Applications: Insights in Mirna and Lncrna Implications, Cells (2023)

34. Dysregulated of the Fam138e and Clrn1-As1 Lncrnas Could Be Diagnosis Biomarkers in Colorectal Cancer, Human Gene (2024)

35. Lncarod Promotes the Proliferation and Migration of Gastric Cancer: A Bioinformatics Analysis and Experimental Validation, Functional and Integrative Genomics (2023)

36. Lncrna Flvcr1-As1 Sponges Mir-381-3P and Promotes Wnt Signaling Pathway Resulting in Colorectal Cancer Progression, Egyptian Journal of Medical Human Genetics (2025)

37. The Significant Role of Micrornas in Gliomas Angiogenesis: A Particular Focus on Molecular Mechanisms and Opportunities for Clinical Application, Cellular and Molecular Neurobiology (2023)

38. System Biology Analysis to Develop Diagnostic Biomarkers, Monitoring Pathological Indexes, and Novel Therapeutic Approaches for Immune Targeting Based on Maggot Bioactive Compounds and Polyphenolic Cocktails in Mice With Gastric Cancer, Environmental Research (2023)

39. The Rna Binding Protein Musashi1 Regulates Apoptosis, Gene Expression and Stress Granule Formation in Urothelial Carcinoma Cells, Journal of Cellular and Molecular Medicine (2011)

40. Aberrant Expression of Plncrna-1 and Tug1: Potential Biomarkers for Gastric Cancer Diagnosis and Clinically Monitoring Cancer Progression, Biomarkers in Medicine (2017)

41. Deciphering the Multifaceted Role of Micrornas in Hepatocellular Carcinoma: Integrating Literature Review and Bioinformatics Analysis for Therapeutic Insights, Heliyon (2024)

42. In Silico Identification and in Vitro Evaluation of Mrps30-Dt Lncrna and Mrps30 Gene Expression in Breast Cancer, Cancer Reports (2024)

43. Micrornas Regulating Wnt Signaling Pathway in Colorectal Cancer: Biological Implications and Clinical Potentials, Functional and Integrative Genomics (2022)

44. Highlighting Roles of Autophagy in Human Diseases: A Perspective From Single-Cell Rna Sequencing Analyses, Drug Discovery Today (2024)

45. Functional Roles of Lncrna-Tug1 in Hepatocellular Carcinoma, Life Sciences (2022)

46. A Review on Expression and Regulatory Mechanisms of Mir-337-3P in Cancer, Journal of Biomolecular Structure and Dynamics (2024)

47. Lna Inhibitor in Microrna Mir-23B As a Potential Anti-Proliferative Option in Human Hepatocellular Carcinoma, Journal of Gastrointestinal Cancer (2020)

48. The Role of Lncrna Mcm3ap-As1 in Human Cancer, Clinical and Translational Oncology (2023)

49. Inducing Cell Proliferative Prevention in Human Acute Promyelocytic Leukemia by Mir-182 Inhibition Through Modulation of Casp9 Expression, Biomedicine and Pharmacotherapy (2017)

50. Modulation of Long Non-Coding Rnas by Resveratrol As a Potential Therapeutic Approach in Cancer: A Comprehensive Review, Pathology Research and Practice (2023)

Style	Citing Format
MLA	Farzaneh M, et al.. "An Updated Review of Contribution of Long Noncoding Rna-Neat1 to the Progression of Human Cancers." Pathology Research and Practice, vol. 245, no. , 2023, pp. -.
APA	Farzaneh M, Masoodi T, Ghaedrahmati F, Radoszkiewicz K, Anbiyaiee A, Sheykhisabzehpoush M, Rad NK, Uddin S, Jooybari SPM, Khoshnam SE, Azizidoost S (2023). An Updated Review of Contribution of Long Noncoding Rna-Neat1 to the Progression of Human Cancers. Pathology Research and Practice, 245(), -.
Chicago	Farzaneh M, Masoodi T, Ghaedrahmati F, Radoszkiewicz K, Anbiyaiee A, Sheykhisabzehpoush M, Rad NK, et al.. "An Updated Review of Contribution of Long Noncoding Rna-Neat1 to the Progression of Human Cancers." Pathology Research and Practice 245, no. (2023): -.
Harvard	Farzaneh M et al. (2023) 'An Updated Review of Contribution of Long Noncoding Rna-Neat1 to the Progression of Human Cancers', Pathology Research and Practice, 245(), pp. -.
Vancouver	Farzaneh M, Masoodi T, Ghaedrahmati F, Radoszkiewicz K, Anbiyaiee A, Sheykhisabzehpoush M, et al.. An Updated Review of Contribution of Long Noncoding Rna-Neat1 to the Progression of Human Cancers. Pathology Research and Practice. 2023;245():-.
BibTex	@article{ author = {Farzaneh M and Masoodi T and Ghaedrahmati F and Radoszkiewicz K and Anbiyaiee A and Sheykhisabzehpoush M and Rad NK and Uddin S and Jooybari SPM and Khoshnam SE and Azizidoost S}, title = {An Updated Review of Contribution of Long Noncoding Rna-Neat1 to the Progression of Human Cancers}, journal = {Pathology Research and Practice}, volume = {245}, number = {}, pages = {-}, year = {2023} }
RIS	TY - JOUR AU - Farzaneh M AU - Masoodi T AU - Ghaedrahmati F AU - Radoszkiewicz K AU - Anbiyaiee A AU - Sheykhisabzehpoush M AU - Rad NK AU - Uddin S AU - Jooybari SPM AU - Khoshnam SE AU - Azizidoost S TI - An Updated Review of Contribution of Long Noncoding Rna-Neat1 to the Progression of Human Cancers JO - Pathology Research and Practice VL - 245 IS - SP - EP - PY - 2023 ER -

Science Communicator Platform

Authors

Authors Affiliations

Abstract