Preliminary Results of Iran Premature Coronary Artery Disease (Ipad Study) and Implementation of Ipad Biobank: A Case-Control Study Publisher Pubmed



Zarepur E¹ ; Mohammadifard N² ; Nedaeinia R¹ ; Sadeghi M³ ; Asgary S⁴ ; Gharipour M⁵ ; Zarepur A⁶ ; Moslemi F⁷ ; Sarrafzadegan N^{1, 8} Show Affiliations
Source: Archives of Iranian Medicine Published:2024

Abstract

Background: Iran Premature Coronary Artery Disease (IPAD) is one of the first and largest studies of its kind in Asia that investigates different aspects of premature coronary artery disease (PCAD) in different ethnic groups in multiple cities. In this paper, we aim to describe the IPAD biobank establishment and present some preliminary results of the IPAD study. Methods: This case-control study was conducted on patients with documented angiography from different ethnicities in more than ten cities of Iran (males aged 60 years and below and females aged 70 years and below). Patients with coronary artery stenosis of more than 75% in at least one vessel (or left-main stenosis of more than 50%) were defined as the case group and patients with normal coronary angiography were considered as the control group. In addition to completing questionnaires and performing physical measurements, samples of serum, buffy coat, plasma, whole blood, saliva, urine, and feces were stored in the freezer at -80°C. Results: The mean age of patients was 51.1 ± 8.2, of which 43% were women. There were 1221 people in the control group and 1702 in the case group. Our enrollment is completed and data entry and transferring biosamples from different cities is still ongoing. About 30 000 biosamples of different ethnicities are saved in the IPAD biobank. Conclusion: This study aims to develop a high-quality biobank and facilitate research on different aspects of PCAD, especially gene-environment interaction regarding ethnicity. © 2024 Academy of Medical Sciences of I.R. Iran. All rights reserved.