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Adherence to Eat-Lancet Reference Diet and Risk of Premature Coronary Artery Diseases: A Multi-Center Case-Control Study Publisher Pubmed

Summary: A study links plant-based EAT-Lancet diet to 70% lower heart disease risk, promoting sustainable eating. #HeartHealth #SustainableDiet

Ataei Kachouei A1 ; Mohammadifard N1 ; Haghighatdoost F2 ; Hajihashemi P3 ; Zarepur E1, 4 ; Nouhi F5, 6 ; Kazemi T7, 8 ; Salehi N9 ; Solati K10 ; Ghaffari S11 ; Gholipour M12 ; Heybar H13 ; Alikhasi H14 ; Sarrafzadegan N2, 15
Authors

Source: European Journal of Nutrition Published:2024


Abstract

Background: In 2019, a globally sustainable dietary pattern that primarily emphasizes the consumption of plant-based foods was proposed by the EAT-Lancet Commission. However, there is limited evidence regarding the association of this diet with coronary events. Objectives: To determine the association between the EAT-Lancet Reference Diet (ELD) and premature coronary artery disease (PCAD) risk and its severity. Methods: This multi-center, case-control study was conducted within the framework of the Iran premature coronary artery disease (I-PAD). A total of 3185 participants aged under 70 years in women and 60 years in men were included. Cases were those whose coronary angiography showed stenosis ≥ 75% in at least one vessel or ≥ 50% in the left main artery (n = 2033), while the controls had normal angiography results (n = 1152). Dietary intake was assessed using a validated food frequency questionnaire. Logistic regression was utilized to examine the association between ELD and presence of PCAD. Results: Compared with individuals in the first quartile, those in the highest quartile of ELD (OR = 0.29, 95% CI: 0.21, 0.39; P for trend < 0.001) and ELD calculated with minimum intake (OR = 0.39, 95% CI: 0.29, 0.52; P < 0.001) had lower risk of PCAD. Individuals in the highest quartile of adherence to the ELD and ELD with minimum intake had 78% and 72% lower risk of having severe PCAD compared with those in the lowest quartile, respectively. Conclusion: An inverse association was observed between adherence to the ELD and PCAD risk and its severity. Large-scale prospective cohort studies are required to confirm these findings. © Springer-Verlag GmbH Germany, part of Springer Nature 2024.
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