Isfahan University of Medical Sciences

Science Communicator Platform

Stay connected! Follow us on X network (Twitter):
Share this content! On (X network) By
Ggcn Polymorphism of Erf3a/Gspt1 Gene and Breast Cancer Susceptibility Publisher Pubmed



Miri M1 ; Hemati S2 ; Safari F1 ; Tavassoli M1
Authors
Show Affiliations
Authors Affiliations
  1. 1. Department of Biology, Faculty of Sciences, University of Isfahan, Hezar-Jarib, Isfahan, Iran
  2. 2. Radiation Oncology Department, Isfahan University of Medical Sciences, Isfahan, Iran

Source: Medical Oncology Published:2012


Abstract

The significance of translation regulatory factors in elevating the risk of cancer has been recently recognized. Eukaryotic release factor 3a (eRF3a) is a translation termination protein that is encoded by G1 to S phase transition 1 gene (GSPT1). The eRF3a/GSPT1 exon 1 contains a trinucleotide GGC repeat coding for a polyglycine expansion in the N-terminal of the protein. In the present study, we determined the allelic length of the GGCn repeat in the eRF3a gene in 250 women with breast cancer and 250 age-matched controls. Our results show that the presence of the longer allele, 12-GGC, is correlated with threefold increased risk of breast cancer development. Our findings also suggest that women who are homozygous for 7-GGC allele are possibly at higher risk of developing breast cancer, especially before the age of 50. No significant effect of the allelic length of eRF3a/GSPT1 polymorphism on inheritance or the grade of this disease was observed. © Springer Science+Business Media, LLC 2011.
Related Docs
View other Related Docs
1. Eukaryotic Release Factor 3 and Risk of Breast Cancer, Journal of Isfahan Medical School (2013)
2. The Study of Ggc Repeat Polymorphism in Exon 1Of Gspt1/Erf3 Gene and Its Association With the Risk of Colorectal Cancer in Isfahan Region, Iran, Journal of Isfahan Medical School (2015)
3. Association Between the Lengths of Gt Dinucleotide Repeat in the Pik3ca Gene With Breast Cancer Risk, Medical Oncology (2014)
4. Association of the Length of Ca Dinucleotide Repeat in the Epidermal Growth Factor Receptor With Risk and Age of Breast Cancer Onset in Isfahan, Journal of Isfahan Medical School (2008)
5. Trinucleotide Repeat Polymorphism in Transforming Growth Factor Beta Receptor Type 1 Gene and Risk of Breast Cancer, Journal of Isfahan Medical School (2013)
6. Polymorphic Aaag Repeat Length in Estrogen-Related Receptor Gamma (Errγ) and Risk of Breast Cancer in Iranian Women, Cancer Investigation (2013)
7. A Study of the Long-Term Trend of Epidemiological and Clinical Indices of Breast Cancer in Isfahan, Journal of Isfahan Medical School (2012)
8. Expression of A2a and A2b Adenosine Receptors in Human Breast Tumors, Journal of Isfahan Medical School (2011)
Experts (# of related papers)
View all Related Experts
Simin Hemati (12)
Mojtaba Panjehpour (2)
Other Related Docs
9. Application of the Health Belief Model in Breast Self-Examination by Iranian Female University Students, International Journal of Cancer Management (2018)
10. A Comprehensive Reference for Brca1/2 Genes Pathogenic Variants in Iran: Published, Unpublished and Novel, Familial Cancer (2022)
11. Study of P53 Polymorphism at Codon 72 in Patients of Breast Cancer in Isfahan, Journal of Isfahan Medical School (2007)
12. Tp53 Pin3 Polymorphism Associated With Breast Cancer Risk in Iranian Women, Indian Journal of Cancer (2011)
13. The Direct Medical Costs of Breast Cancer in Iran: Analyzing the Patient's Level Data From a Cancer Specific Hospital in Isfahan, International Journal of Preventive Medicine (2013)
14. The Association Between Ca Polymorphism in Src Gene and Risk of Breast Cancer, Journal of Isfahan Medical School (2017)
15. Association Analysis of Rs1695 and Rs1138272 Variations in Gstp1 Gene and Breast Cancer Susceptibility, Asian Pacific Journal of Cancer Prevention (2020)
16. Expression of A1 and A3 Adenosine Receptors in Human Breast Tumors, Tumori (2012)
17. Fto Genotype Was Associated With Breast Cancer in Her2 Negative Patients, Clinical Nutrition ESPEN (2022)
18. Association of P53 (+16Ins-Arg) Haplotype With the Increased Susceptibility to Breast Cancer in Iranian-Azeri Women, Journal of Kerman University of Medical Sciences (2018)
19. Genomic Rearrangement Screening of the Brca1 From Seventy Iranian High-Risk Breast Cancer Families, Journal of Research in Medical Sciences (2016)
20. The Relationship of Cac Polymorphism in Hoxa1 Gene and Breast Cancer, Journal of Isfahan Medical School (2014)
21. Comprehensive Analysis of the Prognostic Value of Glutathione S-Transferases Mu Family Members in Breast Cancer, Cell Biology International (2024)
22. Therapeutic Potential of Plk1, Kif4a, Cdca5, Ube2c, Cdt1, Ska3, Aurkb, and Pttg1 Genes in Triple-Negative Breast Cancer: Correlating Their Expression With Sensitivity to Gsk 461364 and Ikk 16 Drugs, Biochemical Genetics (2024)
23. Clinicopathological Analysis of Patients With Breast Cancer and Their Families, Iranian Journal of Blood and Cancer (2016)
24. Tgfbr1 Polymorphism and Risk of Breast Cancer in Iranian Women, International Journal of Biological Markers (2015)
25. Estimating Out-Of-Pocket Payments Among Iranian Women With Breast Cancer, International Journal of Cancer Management (2023)
26. Glis2 and Ccnd1 Expression Levels in Breast Cancer Patients, Breast Disease (2023)
27. Polymorphisms of Satellite Dna Cyp19 Gene and Its Association With Increased Risk of Breast Cancer in Isfahan, Iran, Journal of Isfahan Medical School (2012)
28. The Study of Taaaa Polymorphism in P53 Gene and Its Association With Breast Cancer, Journal of Isfahan Medical School (2015)