Isfahan University of Medical Sciences

Science Communicator Platform

Stay connected! Follow us on X network (Twitter):
Share this content! On (X network) By
Comprehensive Analysis of the Prognostic Value of Glutathione S-Transferases Mu Family Members in Breast Cancer Publisher Pubmed



Gohari N1 ; Abbasi E2 ; Akrami H3
Authors
Show Affiliations
Authors Affiliations
  1. 1. Department of Biology, College of Sciences, Shiraz University, Shiraz, Iran
  2. 2. Cellular, Molecular and Genetics Research Center, Isfahan University of Medical Sciences, Isfahan, Iran
  3. 3. in Gastroenterohepatology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran

Source: Cell Biology International Published:2024


Abstract

Breast cancer (BC) remains a significant public health concern globally, with a high number of reported cases and a substantial number of deaths every year. Accumulating reactive oxygen species (ROS) and oxidative stress are related to BC and the Glutathione S-transferases Mu (GSTM) family is one of the most important enzymatic detoxifiers associated with many cancers. In this study, UALCAN, Kaplan-Meier plotter, bc-GenExMiner, cBioPortal, STRING, Enrichr, and TIMER databases were employed to carry out a comprehensive bioinformatic analysis and provide new insight into the prognostic value of GSTMs in BC. GSTM2-5 genes in mRNA and protein levels were found to be expressed at lower levels in breast tumors compared to normal tissues, and reduction in mRNA levels is linked to shorter overall survival (OS) and relapse-free survival (RFS). The lower mRNA levels of GSTMs were strongly associated with the worse Scarff-Bloom-Richardson (SBR) grades (p < 0.0001). The mRNA levels of all five GSTMs were substantially higher in estrogen receptor (ER)-positive and progesterone receptor (PR)-positive compared to ER-negative and PR-negative BC patients. As well, when nodal status was compared, GSTM1, GSTM3, and GSTM5 were significantly higher in nodal-positive BC patients (p <.01). Furthermore, GSTM4 had the most gene alteration (4%) among other family members, and GSTM5 showed the strongest correlation with CD4+ T cells (Cor=.234, p = 2.22e-13). In conclusion, our results suggest that GSTM family members may be helpful as biomarkers for prognosis and as therapeutic targets in BC. © 2024 International Federation for Cell Biology.
Related Docs
View other Related Docs
1. The Cytotoxic Effect of Memantine and Its Effect on Cytoskeletal Proteins Expression in Metastatic Breast Cancer Cell Line, Iranian Journal of Basic Medical Sciences (2017)
2. Association of Pon1-L55m Genetic Variation and Breast Cancer Risk: A Case-Control Trial, Asian Pacific Journal of Cancer Prevention (2020)
3. Persianolide-A, an Eudesmanolide-Type Sesquiterpene Lactone From Artemisia Kopetdaghensis, Induces Apoptosis by Regulating Erk Signaling Pathways, Research in Pharmaceutical Sciences (2024)
4. Altered Expression of Linc-Ror in Cancer Cell Lines and Tissues, Tumor Biology (2016)
5. Glucosamine Attenuates Drug Resistance in Mitoxantrone-Resistance Breast Cancer Cells, Journal of Pharmacy and Pharmacology (2021)
6. Association Analysis of Rs1695 and Rs1138272 Variations in Gstp1 Gene and Breast Cancer Susceptibility, Asian Pacific Journal of Cancer Prevention (2020)
7. Time-Series Bioinformatics Analysis of Sars-Cov-Infected Cells to Identify the Biological Processes Associated With Severe Acute Respiratory Syndrome, Human Antibodies (2024)
8. Expression Analysis of Hif-3Α As a Potent Prognostic Biomarker in Various Types of Human Cancers: A Case of Meta-Analysis, Research in Pharmaceutical Sciences (2022)
Experts (# of related papers)
View all Related Experts
Mustafa Ghanadian (2)
Maedeh Ghasemi (2)
Other Related Docs
9. Gene Expression Profiles of Cyp24a1 and Cyp27b1 in Malignant and Normal Breast Tissues, Molecular Medicine Reports (2017)
10. Atorvastatin Enhances Anti-Apoptotic Effects of Tamoxifen on Melanoma Cancer Cells, Bratislava Medical Journal (2019)
11. Pimpinelol, a Novel Atypical Sesquiterpene Lactone From Pimpinella Haussknechtii Fruits With Evaluation of Endoplasmic Reticulum Stress in Breast Cancer Cells, Fitoterapia (2018)
12. In Silico Identification and in Vitro Evaluation of Mrps30-Dt Lncrna and Mrps30 Gene Expression in Breast Cancer, Cancer Reports (2024)
13. Ggcn Polymorphism of Erf3a/Gspt1 Gene and Breast Cancer Susceptibility, Medical Oncology (2012)
14. Association of Sod2 Rs2758339, Rs5746136 and Rs2842980 Polymorphisms With Increased Risk of Breast Cancer: A Haplotype-Based Case–Control Study, Genes and Genomics (2023)
15. An Immunohistochemistry Study of Tissue Bcl-2 Expression and Its Serum Levels in Breast Cancer Patients, Annals of the New York Academy of Sciences (2008)
16. Therapeutic Potential of Plk1, Kif4a, Cdca5, Ube2c, Cdt1, Ska3, Aurkb, and Pttg1 Genes in Triple-Negative Breast Cancer: Correlating Their Expression With Sensitivity to Gsk 461364 and Ikk 16 Drugs, Biochemical Genetics (2024)
17. Estrogen Receptor Beta (Erβ) May Act As Mediator in Apoptotic Induction of Grape Seed Extract (Gse), Asian Pacific Journal of Cancer Prevention (2019)
18. Evaluation of the Gene Encoding Carnitine Transporter (Octn2/Slc22a5) Expression in Human Breast Cancer and Its Association With Clinicopathological Characteristics, Molecular Biology Reports (2023)
19. Deregulation of Mir-1245B-5P and Mir-92A-3P and Their Potential Target Gene, Gata3, in Epithelial–Mesenchymal Transition Pathway in Breast Cancer, Cancer Reports (2024)
20. The Antagonistic Atorvastatin-Glibenclamide Interactions Suppressed the Atorvastatin-Induced Bax/Cytochrome C/P53 Mrna Expressions and Increased Rho a Mrna Expression in B16f10 Melanoma Cell Culture, Gene Reports (2021)
21. The Growth Inhibitory Effect of Resveratrol and Gallic Acid on Prostate Cancer Cell Lines Through the Alteration of Oxidative Stress Balance: The Interplay Between Nrf2, Ho-1, and Bach1 Genes, Anti-Cancer Agents in Medicinal Chemistry (2024)
22. Unfavorable Prognosis and Clinical Consequences of Apobec3b Expression in Breast and Other Cancers: A Systematic Review and Meta-Analysis, Tumor Biology (2022)
23. A Comparative Study of Hotair Expression in Breast Cancer Patient Tissues and Cell Lines, Cell Journal (2019)
24. Glis2 and Ccnd1 Expression Levels in Breast Cancer Patients, Breast Disease (2023)