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The Therapeutic Effect of Mscs and Their Extracellular Vesicles on Neuroblastoma Publisher Pubmed



Karami Fath M1 ; Bagherzadeh Torbati SM2 ; Saqagandomabadi V3 ; Yousefi Afshar O4 ; Khalilzad M5 ; Abedi S6 ; Moliani A7 ; Daneshdoust D2 ; Barati G8
Authors
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Authors Affiliations
  1. 1. Department of Cellular and Molecular Biology, Faculty of Biological Sciences, Kharazmi University, Tehran, Iran
  2. 2. Faculty of Medicine, Babol University of Medical Sciences, Mazandaran, Iran
  3. 3. Department of Biomedicine, Neuroscience and Advanced Diagnostics, University of Palermo, Palermo, Italy
  4. 4. Clinical Research Development Unit, Valiasr Hospital, Tabriz, Iran
  5. 5. Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran
  6. 6. Faculty of Natural Sciences, University of Tabriz, Tabriz, Iran
  7. 7. Isfahan Medical Students Research Center, Isfahan University of Medical Sciences, Isfahan, Iran
  8. 8. Stem Cell Technology Research Center, Tehran, Iran

Source: Progress in Biophysics and Molecular Biology Published:2024


Abstract

Neuroblastoma is a common inflammatory-related cancer during infancy. Standard treatment modalities including surgical interventions, high-dose chemotherapy, radiotherapy, and immunotherapy are not able to increase survival rate and reduce tumor relapse in high-risk patients. Mesenchymal stem cells (MSCs) are known for their tumor-targeting and immunomodulating properties. MSCs could be engineered to express anticancer agents (i.e., growth factors, cytokines, pro-apoptotic agents) or deliver oncolytic viruses in the tumor microenvironment. As many functions of MSCs are mediated through their secretome, researchers have tried to use extracellular vesicles (EVs) from MSCs for targeted therapy of neuroblastoma. Here, we reviewed the studies to figure out whether the use of MSCs could be worthwhile in neuroblastoma therapy or not. Native MSCs have shown a promoting or inhibiting role in cancers including neuroblastoma. Therefore, MSCs are proposed as a vehicle to deliver anticancer agents such as oncolytic viruses to the neuroblastoma tumor microenvironment. Although modified MSCs or their EVs have been shown to suppress the tumorigenesis of neuroblastoma, further pre-clinical and clinical studies are required to come to a conclusion. © 2024 Elsevier Ltd
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