Isfahan University of Medical Sciences

Science Communicator Platform

Stay connected! Follow us on X network (Twitter):
Share this content! On (X network) By
The Effect of Pioglitazone on Circulating Interleukin-10 and Tumor Necrosis Factor-Alpha Levels in a Patient With Metabolic Syndrome: A Randomized, Double-Blind Controlled Trial



Pourmoghaddas A1 ; Dormianitabatabaei M2 ; Sadeghi M2 ; Kermanialghoraishi M2 ; Golshahi J3 ; Shokouh P4
Authors
Show Affiliations
Authors Affiliations
  1. 1. Isfahan Cardiovascular Research Center, Isfahan Cardiovascular Research Institute, Isfahan University of Medical Sciences, Isfahan, Iran
  2. 2. Cardiac Rehabilitation Research Center, Isfahan Cardiovascular Research Institute, Isfahan University of Medical Sciences, Isfahan, Iran
  3. 3. Hypertension Research Center, Isfahan Cardiovascular Research Institute, Isfahan University of Medical Sciences, Isfahan, Iran
  4. 4. Heart Failure Research Center, Isfahan Cardiovascular Research Institute, Isfahan University of Medical Sciences, Isfahan, Iran

Source: ARYA Atherosclerosis Published:2015

Abstract

BACKGROUND: This study aimed to evaluate the effect of pioglitazone as an insulin sensitizer on circulating interleukin-10 (IL-10) as an anti-inflammatory factor and tumor necrosis factor-alpha (TNF-α) as main proinflammatory factor in non-diabetic metabolic syndrome (MetS) patients in Caucasians race of Middle East area in Iran. METHODS: We conducted a randomized double-blind controlled study of 68 non-diabetic patients with MetS. Patients were randomly divided into two groups including intervention group received pioglitazone 30 mg daily for 24 weeks, and the control group received placebo pills for the same duration. Circulating levels of TNF-α and IL-10 were assessed as a primary goal. Lipid profile, liver enzymes, blood pressure (BP), waist circumference, and body mass index (BMI) also were measured. RESULTS: Lipid profile and fasting blood sugar had non-significant changes after treatment by pioglitazone, but BMI was increased significantly (P = 0.002). BP and waist circumference had a significant decrease in both groups (P < 0.050). Aspartate transaminase and alanine transaminase were decreased significantly in the pioglitazone group (P = 0.002). TNF-α decreased non-significantly in both groups (P > 0.050). IL-10 increased in intervention group non-significantly (P = 0.971); whereas in placebo group decreased to a little extent (P = 0.401). C-reactive protein was also decreased insignificant after receive pioglitazone (P = 0.333). There was no significant difference in all variables between the two groups (P > 0.050) except liver enzymes (P < 0.050). CONCLUSION: This study indicates that the pioglitazone has no positive effect on improving inflammatory status in the non-diabetes patients with MetS. © 2015, Isfahan University of Medical Sciences(IUMS). All rights reserved.
Related Docs
View other Related Docs
1. Effects of Pioglitazone on Asymmetric Dimethylarginine and Components of the Metabolic Syndrome in Nondiabetic Patients (Epicamp Study): A Double-Blind, Randomized Clinical Trial, PPAR Research (2013)
2. Effect of Pioglitazone on Nonalcoholic Fatty Liver Disease in Morbid Obese Patients; a Randomized Controlled Trial, Advanced Biomedical Research (2023)
3. Impact of Metformin and Pioglitazone on Serum Level of Tumor Necrosis Factor-Alpha and Lipid Profiles During Implantation Window in Diabetic Rats, International Journal of Fertility and Sterility (2019)
4. First Nationwide Study of the Prevalence of the Metabolic Syndrome and Optimal Cutoff Points of Waist Circumference in the Middle East: The National Survey of Risk Factors for Noncommunicable Diseases of Iran, Diabetes Care (2009)
5. Meta-Inflammatory State and Insulin Resistance Can Improve After 10 Weeks of Combined All-Extremity High-Intensity Interval Training in Sedentary Overweight/Obese Females: A Quasi-Experimental Study, Journal of Diabetes and Metabolic Disorders (2020)
6. Effect of Zinc Supplementation on Lipid Profile and Body Composition in Patients With Type 2 Diabetes Mellitus: A Grade-Assessed Systematic Review and Dose-Response Meta-Analysis, Biological Trace Element Research (2024)
7. Evaluating the Effects of Acarbose on Anthropometry Indexes and Metabolic Markers in Patients With Metabolic Syndrome in Comparison to Placebo, in Isfahan City, Iran, Journal of Isfahan Medical School (2018)
8. A Personalised Diet Approach Study: Interaction Between Ppar-Γ Pro12ala and Dietary Insulin Indices on Metabolic Markers in Diabetic Patients, Journal of Human Nutrition and Dietetics (2022)
Experts (# of related papers)
View all Related Experts
Nizal Sarrafzadegan (10)
Roya Kelishadi (10)
Other Related Docs
9. Association of Dietary Pattern and Metabolic Syndrome in 15- to 49-Years-Old Women, Journal of Isfahan Medical School (2015)
10. Interaction Between Dietary Total Antioxidant Capacity and Bdnf Val66met Polymorphism on Lipid Profiles and Atherogenic Indices Among Diabetic Patients, Scientific Reports (2021)
11. Prognostic Value of Circulating Macrophage Inhibitory Cytokine 1-Growth Differentiation Factor 15 (Mic-1/Gdf15) in Obesity: Relation With Vascular Endothelial Growth Factor (Vegf) and Markers of Oxidative Stress, Nutrition and Health (2023)
12. Cholesterol Synthesis and Absorption Markers in Type 2 Diabetes Mellitus, Journal of Isfahan Medical School (2019)
13. Incidence of Metabolic Syndrome and Its Risk Factors Among Type 2 Diabetes Clinic Attenders in Isfahan, Iran, Endokrynologia Polska (2012)
14. Effects of Daily Consumption of Cashews on Oxidative Stress and Atherogenic Indices in Patients With Type 2 Diabetes: A Randomized, Controlled-Feeding Trial, International Journal of Endocrinology and Metabolism (2019)
15. Influence of Statins on Circulating Inflammatory Cytokines in Patients With Abnormal Glucose Homeostasis: A Meta-Analysis of Data From Randomized Controlled Trials, Clinical Therapeutics (2020)
16. Adherence to Lifelines Diet Score and Risk Factors of Metabolic Syndrome Among Overweight and Obese Adults: A Cross-Sectional Study, Frontiers in Nutrition (2022)
17. A Personalised Diet Study: The Interaction Between Apoa2 −265T > C Polymorphism and Dietary Inflammatory Index on Oxidative and Inflammatory Markers and Lipid Profile in Patients With Type 2 Diabetes Mellitus: A Cross-Sectional Study, International Journal of Clinical Practice (2021)
18. Effects of Dietary Whole Grain, Fruit, and Vegetables on Weight and Inflammatory Biomarkers in Overweight and Obese Women, Eating and Weight Disorders (2020)
19. The Association of Hypertriglyceridemic Waist Phenotype With Type 2 Diabetes Mellitus Among Individuals With First Relative History of Diabetes, Journal of Research in Medical Sciences (2011)
20. The Impact of a Community Trial on the Pharmacological Treatment in the Individuals With the Metabolic Syndrome: Findings From the Isfahan Healthy Heart Program, 2001-2007, Archives of Medical Science (2012)
21. Clinical Trial of the Effects of Coenzyme Q10 Supplementation on Glycemic Control and Markers of Lipid Profiles in Diabetic Hemodialysis Patients, International Urology and Nephrology (2018)
22. The Relationship Between Low-Carbohydrate Diet Score, Dietary Insulin Index and Load With Obesity in Healthy Adults, Eating and Weight Disorders (2022)
23. The Effects of Macronutrient Intake on the Risk of Pre-Diabetes in First- Degree Relatives of Patients With Type 2 Diabetes, Journal of Isfahan Medical School (2014)
24. The Effects of Ursodeoxycholic Acid on Cardiometabolic Risk Factors: A Systematic Review and Meta-Analysis of Randomized Controlled Trials, BMC Cardiovascular Disorders (2025)
25. Effect of Non-Soy Legume Consumption on Inflammation and Serum Adiponectin Levels Among First-Degree Relatives of Patients With Diabetes: A Randomized, Crossover Study, Nutrition (2015)
26. The Association of Dietary Phytochemical Index and Nonalcoholic Fatty Liver Disease, Food Science and Nutrition (2023)
27. Low-Carbohydrate-Diet Score and Metabolic Syndrome: An Epidemiologic Study Among Iranian Women, Nutrition (2015)
28. The Impact of a Low Glycemic Index Diet on Inflammatory Markers and Serum Adiponectin Concentration in Adolescent Overweight and Obese Girls: A Randomized Clinical Trial, Hormone and Metabolic Research (2016)
29. Oral Herbal Supplement Containing Magnesium Sulfate Improve Metabolic Control and Insulin Resistance in Non-Diabetic Overweight Patients: A Randomized Double Blind Clinical Trial, Medical Journal of the Islamic Republic of Iran (2019)
30. Effects of Therapeutic Lifestyle Change Diets on Blood Lipids, Lipoproteins, Glycemic Parameters, and Blood Pressure: A Systematic Review and Meta-Analysis of Clinical Trials, Nutrition Reviews (2024)
31. Calcium-Vitamin D Cosupplementation Influences Circulating Inflammatory Biomarkers and Adipocytokines in Vitamin D-Insufficient Diabetics: A Randomized Controlled Clinical Trial, Journal of Clinical Endocrinology and Metabolism (2014)
32. The Effect of Phytochemicals in Prediabetic Patients: A Systematic Review of Randomized Controlled Trials, Phytotherapy Research (2023)
33. The Effects of Vitamin D Supplementation on Inflammatory Biomarkers in Patients With Abnormal Glucose Homeostasis: A Systematic Review and Meta-Analysis of Randomized Controlled Trials, Pharmacological Research (2021)
34. Association Between Dietary Insulin Index and Load With Brain Derived Neurotrophic Factor, Adropin and Metabolic Health Status in Iranian Adults, Scientific Reports (2023)
35. Long Term Effects of Oral Vitamin E Supplement in Type Ii Diabetic Patients, International Journal for Vitamin and Nutrition Research (2005)
36. Diabetes and Associated Cardiovascular Risk Factors in Iran: The Isfahan Healthy Heart Programme, Annals of the Academy of Medicine Singapore (2007)
37. Dietary Insulin Index and Insulin Load in Relation to Hypertriglyceridemic Waist Phenotype and Low Brain Derived Neurotrophic Factor in Adults, Frontiers in Nutrition (2022)
38. Reduction of Proteinuria by Pioglitazone in Patients With Non-Diabetic Renal Disease, Journal of Research in Medical Sciences (2011)
39. Correlation of Circulating Inflammatory Markers, Ghrelin, Adiponectin With Obesity Indices in Subjects With Metabolic Syndrome, Pakistan Journal of Medical Sciences (2013)
40. Effect of Fermented Camel Milk on Glucose Metabolism, Insulin Resistance, and Inflammatory Biomarkers of Adolescents With Metabolic Syndrome: A Double-Blind, Randomized, Crossover Trial, Journal of Research in Medical Sciences (2018)
41. Salsalate Efficacy in Blood Glucose Level Reduction in Diabetes, Journal of Isfahan Medical School (2009)
42. The Effects of Magnesium Supplementation on Blood Pressure and Obesity Measure Among Type 2 Diabetes Patient: A Systematic Review and Meta-Analysis of Randomized Controlled Trials, Biological Trace Element Research (2021)
43. Hypertriglyceridemic Waist Phenotype, Markers of Systemic Inflammation and Endothelial Dysfunction Among Women, Iranian Journal of Diabetes and Lipid Disorders (2007)
44. The Alternate-Day Fasting Diet Is a More Effective Approach Than a Calorie Restriction Diet on Weight Loss and Hs-Crp Levels, International Journal for Vitamin and Nutrition Research (2021)
45. The Effect of Hydroalcoholic Saffron (Crocus Sativus L.) Extract on Fasting Plasma Glucose, Hba1c, Lipid Profile, Liver, and Renal Function Tests in Patients With Type 2 Diabetes Mellitus: A Randomized Double-Blind Clinical Trial, Phytotherapy Research (2019)
46. The Beneficial Effects of Crocin Supplementation on Metabolic and Genetic Parameters in Type 2 Diabetic Patients Under Metformin Treatment: A Randomized Double-Blind Controlled Clinical Trial, Journal of Functional Foods (2024)
47. Association of Serum Ceruloplasmin Level With Obesity: Some Components of Metabolic Syndrome and High-Sensitive C-Reactive Protein in Iran, Journal of Obesity (2012)
48. The Relationship Between Diet Quality Index and Components of Metabolic Syndrome, Journal of Health System Research (2024)
49. The Effects of Policosanol Supplementation on Blood Glucose: A Systematic Review and Dose-Response Meta-Analysis of Randomized Controlled Trials, Diabetes Research and Clinical Practice (2024)
50. Effects of Sodium-Glucose Co-Transporter-2 Inhibitors on Anthropometric Indices and Metabolic Markers in Overweight/Obese Individuals Without Diabetes: A Systematic Review and Meta-Analysis, Current Medical Research and Opinion (2022)